Directori
ALDEA MALO, Martí
CV
Perfil del professor
Professor Catedràtic
Ciències Bàsiques, DEPARTAMENT DE CIÈNCIES BÀSIQUES. Universitat Internacional de Catalunya
Formació Acadèmica
- Otros Universitat Autònoma de Barcelona
Formació acadèmica
Doctor en Ciencias Biológicas, UNIVERSITAT AUTÒNOMA DE BARCELONA
Llicenciat en Bioquimica, UNIVERSITAT AUTÒNOMA DE BARCELONA
Llicenciat en Ciencias Biológicas, UNIVERSITAT AUTÒNOMA DE BARCELONA
Llicenciat en Bioquimica, UNIVERSITAT AUTÒNOMA DE BARCELONA
Llicenciat en Ciencias Biológicas, UNIVERSITAT AUTÒNOMA DE BARCELONA
Experiència professional
2010 Professor de Recerca, Consell Superior d'Investigacions Científiques
2003-2009 Catedràtic d'Universitat, Universitat de Lleida
1992-2002 Professor Titular d'Universitat, Universitat de Lleida
1988-1991 Becari Postdoctoral de Reincorporació, C. Investigacions Biològiques. CSIC
1987-1988 Research Associate, Dept. of Genetics. UGA. USA.
1985-1986 Becari Postdoctoral, Dept. of Genetics. UGA. USA.
1983-1985 Becari Postdoctoral, Inst. Biologia Cel·lular. CSIC
1978-1981 Becari Doctoral, Dept. Microbiologia. UAB.
1977-1983 Professor Ajudant, C. Biologia General. UAB.
2003-2009 Catedràtic d'Universitat, Universitat de Lleida
1992-2002 Professor Titular d'Universitat, Universitat de Lleida
1988-1991 Becari Postdoctoral de Reincorporació, C. Investigacions Biològiques. CSIC
1987-1988 Research Associate, Dept. of Genetics. UGA. USA.
1985-1986 Becari Postdoctoral, Dept. of Genetics. UGA. USA.
1983-1985 Becari Postdoctoral, Inst. Biologia Cel·lular. CSIC
1978-1981 Becari Doctoral, Dept. Microbiologia. UAB.
1977-1983 Professor Ajudant, C. Biologia General. UAB.
Publicacions
Articles
- Pérez-Paredes, A.; Artés, M.H.; Moreno, D.; Clotet, J.; Aldea, M., (2022), "Mad3 modulates the G1 Cdk and acts as a timer in the Start network", Science advances, vol. 8, No. 18, ISSN: 2375-2548.
- Yahya, G.; Pérez-Paredes, A.; Mendoza, M.; Parisi, E.; Moreno, D.; Artés, M.H.; Gallego, C.; Aldea, M., (2021), "Stress granules display bistable dynamics modulated by Cdk", Journal of cell biology, vol. 220, No. 3, ISSN: 0021-9525.
- Moreno, D.; Jenkis, K.; Morlot, S.; Charvin, G.; Csikasz-Nagy, A.; Aldea, M., (2019), "Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1", eLife, vol. 8, ISSN: 2050-084X.
- Moreno, D.; Aldea, M., (2019), "Coincidence analysis of molecular dynamics by raster image correlation spectroscopy", Methods in Molecular Biology, vol. 2040, pp. 375-384, ISSN: 1940-6029 10643745.
- Moreno, D.; Parisi, E.; Yahya, G.; Vaggi, F.; Csikász, A.; Aldea, M., (2019), "Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress", Life Science Alliance, vol. 2, No. 2, ISSN: 2575-1077.
- Parisi, E.; Yahya, G.; Flores, A.; Aldea, M., (2018), "Cdc48/p97 segregase is modulated by cyclin-dependent kinase to determine cyclin fate during G1 progression", Embo journal, vol. 37, No. 16, ISSN: 0261-4189.
- Martínez-Láinez, JM.; Moreno, D.; Parisi, E.; Clotet, J.; Aldea, M., (2018), "Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast", PLOS biology, vol. 16, No. 8, ISSN: 1544-9173.
- Aldea, M.; Jenkins, K.; Csikász, A., (2017), "Growth Rate as a Direct Regulator of the Start Network to Set Cell Size", Frontiers in cell and developmental biology, vol. 5, pp. 57-62, ISSN: 2296-634X.
- Aldea, M., (2017), "Compartmentalization of ER-bound chaperone confines protein deposit formation to the aging yeast cell", Current biology, vol. 27, pp. 773-783, ISSN: 0960-9822.
- Deniz, Ö.; Flores, Ó.; Aldea, M.; Soler-López, M.; Orozco, M., (2016), "Nucleosome architecture throughout the cell cycle", Scientific Reports, vol. 6, No. 19729, pp. 1-11, ISSN: 2045-2322.
- Georgieva, M.V.; Yahya, G.; Codó, L.; Ortíz, R.; Gallego, C.; Orozco, M.; Aldea, M., (2015), "Inntags: small self-structured epitopes for innocuous protein tagging", Nature methods, vol. 12, No. 10, pp. 955-958, ISSN: 1548-7091.
- Yahya, G.; Parisi, E.; Flores, A.; Gallego, C.; Aldea, M., (2014), "A Whi7-anchored loop controls de G1 Cdk-cyclin complex at Start.", Molecular cell, vol. 53, pp. 115-126, ISSN: 1097-2765.
- Menoyo, S.; Ricco, N.; Bru, S.; Hernández-Ortega, S; Escoté, X.; Aldea, M.; Clotet, J., (2013), "Phosphate-Activated Cyclin-Dependent Kinase Stabilizes G(1) Cyclin To Trigger Cell Cycle Entry", Mol Cell Biol., vol. 33(7), pp. 1273-1284, ISSN: 1098-5549.
- Ferrezuelo, F.; Colomina, N.; Palmisano, A.; Garí, E.; Gallego, C.; Csikasz-Nagy, A.; Aldea, M., (2012), "The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation", Nature communications, vol. 3, No. 1012, pp. 1-11, ISSN: 2041-1723.
- Ferrezuelo, F.; Colomina, N.; Futcher, B.; Aldea, M., (2010), "The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle", Genome biology, vol. 11, No. 6, pp. 1-9, ISSN: 1474-760X.
- Vergés, E.; Colomina, N.; Garí, E.; Gallego, C.; Aldea, M., (2007), "Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry", Molecular cell, vol. 26, No. 5, pp. 649-662, ISSN: 1097-2765.
- Clotet, J.; Escoté, X.; Adrover, MÀ; Yaakov, G.; Garí, E.; Aldea, M.; De Nadal, E.; Posas, F., (2006), "Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity.", Embo journal, vol. 25, pp. 2338-2346, ISSN: 0261-4189.
- Clotet, J.; Garí, E.; Aldea, M.; Ariño, J., (1999), "The yeast Ser/Thr phosphatases SIT4 and PPZ1 play opposite roles in the regulation of the cell cycle.", Molecular and cellular biology, vol. 19, pp. 2408-2415, ISSN: 0270-7306.
Projectes de recerca
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Ultradynamic protein assemblies and network channeling01/01/2024 - 31/12/2026IP: Aldea, M.
Agencia EStatal de Investigación
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Protein cluster dynamics and network channeling01/06/2020 - 31/05/2023IP: Aldea, M.
Agencia EStatal de Investigación
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Proteotoxic aggregates, chaperome alterations and cell proliferation decline during cell aging30/12/2016 - 29/12/2019IP: Aldea, M.
MINE - MINECO. Ministerio de Economía y Competitividad
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Prions and aggregons as inhibitors of Start: a path to cell ageing.01/01/2014 - 31/12/2016IP: Aldea, M.
MINE - MINECO. Ministerio de Economía y Competitividad
Activitats
- Federation of European Biochemical Societies Congress Ponència convidada "Growth sensors in the Start network to set cell size", 2017.