Directori
WRIGHT, Roni Helene Grace
Departament de Ciències Bàsiques
From cell metabolism to metabolic diseases (METADIS)
WRIGHT, Roni Helene Grace
CV
Perfil del professor
Professor Col.laborador
Ciències Bàsiques, DEPARTAMENT DE CIÈNCIES BÀSIQUES. Universitat Internacional de Catalunya
Formació Acadèmica
- Molecular Biology University of Glasgow
Formació acadèmica
Doctora Phd Molecular Biology and Cancer - UNIVERSITY OF GLASGOW
Llicenciada Bsc (honors) Biochemistry and Immunology - UNIVERSITY OF STRATHCLYDE
Llicenciada Bsc (honors) Biochemistry and Immunology - UNIVERSITY OF STRATHCLYDE
Publicacions
Articles
- Font Mateu, J.; Sanllehí, P.; Sot, J.; Abad, B.; Mateos, N.; Torreno, J.; Ferrari, R.; Wright, R.; Garcia, M.; Joglar, J.; Goñi, F.; Beato, M., (2024), "A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane", Cellular and molecular life sciences, vol. 81, No. 1, ISSN: 1420-682X.
- Manousakis, E.; Martinez, C.; Guimerà, M.; Wright, R., (2023), "CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, No. 24, ISSN: 1661-6596.
- Ferretti, L.; Böhi, F.; Leslie, D.; Cheng, P.; Ferrari, E.; Baumgaertner, P.; Alvarado, A.; Sella, F.; Cereghetti, A.; Turko, P.; Wright, R.; De Bock, K.; Speiser, D.; Ferrari, R.; Levesque, M.; Hottiger, M., (2023), "Combinatorial treatment with PARP and MAPK inhibitors overcomes phenotype switch-driven drug resistance in advanced melanoma", Cancer research, vol. 83, No. 23, pp. 3974-3988, ISSN: 0008-5472.
- Wright, R., (2022), "The ADP-ribose hydrolase NUDT5 is important for DNA repair", Cell Reports, vol. 41, No. 12, ISSN: 2211-1247.
- Wright, R., (2022), "Global signalling network analysis of luminal T47D breast cancer cells in response to progesterone", Frontiers in Endocrinology, vol. 13, No. 19, pp. 1-19, ISSN: 1664-2392.
- Bisceglie, L.; Hopp, A.-K.; Gunasekera, K.; Wright, R.; Le Dily, F.; Vidal, E.; Dall’Agnese, A.; Caputo, L.; Nicoletti, C.; Puri, P.L.; Beato, M.; Hottiger, M., (2021), "MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast trans-differentiation", Iscience, vol. 24, No. 5, ISSN: 2589-0042.
- Wright, R.; Beato, M., (2021), "Role of the nudt enzymes in breast cancer", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, No. 5, pp. 1-14, ISSN: 1661-6596.
- Beato, M.; Wright, R.; Le Dily, F., (2020), "90 YEARS OF PROGESTERONE: Molecular mechanisms of progesterone receptor action on the breast cancer genome", Journal of molecular endocrinology, vol. 65, No. 1, pp. T65-T79, ISSN: 0952-5041.
- Pickup, K.E.; Pardow, F.; Carbonell, J.; Lioutas, A.; Villanueva, J.; Wright, R.; Beato, M., (2019), "Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5", CANCERS, vol. 11, No. 9, ISSN: 2072-6694.
- Wright, R.; Le Dily, F.; Beato, M., (2019), "ATP, Mg2+, Nuclear Phase Separation, and Genome Accessibility", Trends in biochemical sciences, vol. 44, No. 7, pp. 565-574, ISSN: 0968-0004.
- Sharma, P.; Lioutas, A.; Fernández-Fuentes, N.; Quílez, J.; Carbonell, J.; Wright, R.; Di Vona, C.; Le Dily, F.; Schueller, R.; Eick, D.; Oliva, B.; Beato, M., (2019), "Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription", Molecular cell, vol. 73, No. 1, ISSN: 1097-2765.
- Le Dily, F.; Vidal, E.; Cuartero, Y.; Quílez, J.; Nacht, A.; Vicent, G.; Carbonell, J.; Sharma, P.; Villanueva, J.; Ferrari, R.; de Llobet, L.; Verde, G.; Wright, R.; Beato, M., (2019), "Hormone-control regions mediate steroid receptor–dependent genome organization", Genome research, vol. 29, No. 1, pp. 29-39, ISSN: 1088-9051.
- Verde, G.; de Llobet, L.; Wright, R.; Quílez, J.; Peiró, S.; Le Dily, F.; Beato, M., (2018), "Unliganded Progesterone Receptor Governs Estrogen Receptor Gene Expression by Regulating DNA Methylation in Breast Cancer Cells", CANCERS, vol. 10, No. 10, ISSN: 2072-6694.
- Page, B.D.G.; Valerie, N.C.K.; Wright, R.; Wallner, O.; Isaksson, R.; Carter, M.; Rudd, S.G.; Jemth, A.S.; Almlof, I.; Font-Mateu, J.; Llona-Minguez, S.; Baranczewski, P.; Jeppsson, F.; Homan, E.; Almqvist, H.; Axelsson, H.; Regmi, S.; Gustavsson, A.; Lundback, T.; Scobie, M.; Stromberg, K.; Stenmark, P.; Beato, M.; Helleday, T., (2018), "Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells", Nature communications, vol. 9, ISSN: 2041-1723.
- Wright, R.; Fernández-Fuentes, N.; Oliva, B.; Beato, M., (2016), "Insight into the machinery that oils chromatin dynamics", Nucleus-Austin, vol. 7, No. 6, pp. 532-539, ISSN: 1949-1034.
- Nacht, A. S.; Pohl, A.; Zaurin, R.; Soronellas, D.; Quílez, J.; Sharma, P.; Wright, R.; Beato, M.; Vicent, G., (2016), "Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters", Embo journal, vol. 35, No. 16, pp. 1822-1843, ISSN: 0261-4189.
- Wright, R.; Lioutas, A.; Le Dily, F.; Soronellas, D.; Pohl, A.; Bonet, J.; Nacht, A. S.; Samino, S.; Font-Mateu, J.; Vicent, Guillermo P.; Wierer, M.; Trabado, M.A.; Schelhorn, C.; Carolis, C.; Macias, M.J.; Yanes, O.; Oliva, B.; Beato, M., (2016), "ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling", Science, vol. 352, No. 6290, pp. 1221-1225, ISSN: 0036-8075.
- Vicent, G.; Wright, R.; Beato, M., (2016), "Linker histones in hormonal gene regulation", Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, vol. 1859, No. 3, pp. 520-525, ISSN: 1874-9399.
- Beato, M.; Wright, R.; Vicent, Guillermo P., (2015), "DNA damage and gene transcription: accident or necessity?", Cell research, vol. 25, No. 7, pp. 769-770, ISSN: 1001-0602.
- Le Dily, F.; Bau, D.; Pohl, A.; Vicent, G.; Serra, F.; Soronellas, D.; Castellano, G.; Wright, R.; Ballare, C.; Filion, G.; Marti-Renom, M.; Beato, M., (2014), "Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation", Genes and development, vol. 28, No. 19, pp. 2151-2162, ISSN: 0890-9369.
- Wright, R.; Beato, M., (2012), "PARty promoters Hormone-dependent gene regulation requires CDK2 activation of PARP1", Cell cycle, vol. 11, No. 23, pp. 4291-4293, ISSN: 1538-4101.
- Wright, R.; Castellano, G.; Bonet, J.; Le Dily, F.; Font Mateu, J.; Ballare, C.; Nacht, S.; Soronellas, D.; Oliva, B.; Beato, M., (2012), "CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells", Genes and development, vol. 26, No. 17, pp. 1972-1983, ISSN: 0890-9369.
Activitats
- Cold Spring Harbor PARP1 Meeting Ponència "Role of PARP1 at super enhancers", 2020.
- EMBL Impact of COVID on women Scientists Presentació de comunicació "Same storm, different boats", 2020.