The first quartile journal DNA Repair publishes research from a study on how polyphosphate helps prevent DNA damage, led by researcher Samuel Bru
The study, led by the Faculty of Medicine and Health Sciences’ Department of Basic Sciences, was carried out together with researchers from the University of Lleida’s Biomedical Research Institute, the Vall d’Hebron Research Institute’s Research Group on Neuromuscular and Mitochondrial Diseases and the Rare Diseases Networking Biomedical Research Centre (CIBERER).
Under the title “Polyphosphate is a key factor for cell survival after DNA damage in eukaryotic cells”, the study shows how polyphosphate helps prevent DNA damage. The team of researchers worked with genetically modified eukaryotic cells, which were treated with ultraviolet radiation (UV). The research showed a clear correlation between high levels of intercellular polyphosphate and increased survival following a stimulus, thereby confirming the key role that polyphosphate plays in survival after DNA damage in mammal cells. Lastly, this discovery opens up new avenues in the study of cancer prevention and treatment.