Universitat Internacional de Catalunya
Basic Pharmacology
Other languages of instruction: Catalan, Spanish
Teaching staff
Appointment by e-mail.
Dr Carla Mura, PhD. carla.mura@uic.es
Introduction
Pharmacology is fundamental in the practice of Dentistry and it is the central topic in the research and discovery of new drugs.
Pharmacology studies the drug action mechanism, the pharmacokinetics of the drug, the new drug formulations and delivery systems, the therapeutic index, the toxicity of the drug as well as the adverse reactions and drug interactions. The knowledge of pharmacology has great importance in dentistry research.
Pre-course requirements
Basic knowledge of physiology and cellular and molecular biology.
Objectives
- To present the main parameters used to evaluate the pharmacological effect of drugs.
- To show the main routes of drug administration and the mechanism of drug absorption, metabolism, distribution and elimination, as well as the parameters used in their study.
- To expose the new strategies for drug delivery and site-specific release of drugs.
- To demonstrate the usefulness of the major drug databases.
- To familiarize students with reading and critical understanding of scientific articles in pharmacology.
Competences/Learning outcomes of the degree programme
- CE1 - Ability to apply the scientific method, the experimental design and the biostatistics to solve a problem or corroborate hypothesis.
- CG1 - Ability to integrate new knowledge through research and study, and deal with complexity
- CG3 - Self learning ability in the development of new techniques, in the knowledge of new scientific concepts and in the search of new scientific information
- CT1 - Ability to work in multidisciplinary and multicultural groups
Learning outcomes of the subject
At the end of the course the student should:
- Have acquired advanced knowledge in Dentistry Pharmacology.
- Be able to integrate the knowledge acquired through the research and study.
- Be able to apply the acquired knowledge to solve problems.
- Be able to read and evaluate the scientific publications and to recognize his research interests.
- Have obtained a self-learning ability in the knowledge of new scientific concepts and in the search of new scientific information.
Syllabus
Class 1: Pharmacokinetics and pharmacokinetics parameters
Pharmacokinetics: concepts and introduction to the plasmatic curve.
Absorption: route of drug administration, kinetics of drug absorption.
Distribution: drug transport in the blood and distribution in the tissues, kinetics of drug distribution.
Drug metabolism: concepts and biotransformation reactions.
Elimination: renal, biliary and intestinal excretion, kinetics of drug elimination.
Class 2: New pharmaceutical formulations and strategies for the site-specific delivery of drugs
Modified release of pharmaceutical formulations: delayed, repeated and extended release.
Drug delivery: micro and nanoparticles, liposomes, bio-adhesive systems etc.
Class 3: Routes of Administration and Pharmaceutical Dosage Form
Pharmaceutical Dosage Form: Enteral, parenteral, topical etc.
Routes of Drug Administration: Enteral, parenteral, topical etc.
Transdermal patches
Teaching and learning activities
Online
Teaching methodology: CM, MC, TRB
Training activities: CT
Evaluation systems and criteria
Online
EC (30%)
RC (20%)
PFE (50%)
The final exam will be on the last day of class.
Bibliography and resources
Books
John A. Yagiela, Frank J. Dowd, Bart Johnson, Angelo Mariotti, Enid A. Neidle. “Pharmacology and Therapeutics for Dentistry.” Mosby Elsevier
H. P. Rang, M. Maureen Dale. “Pharmacology”. Elsevier. Churchill Livingstone
Laurence L. Brunton, Bruce A. Chambner, Bjorn C. Knollman. “Goodman and Gilman's The Pharmacological Basis of Therapeutics”.Mc Graw Hill Medical
J Flórez, JA Armijo, A Mediavilla. Farmacología humana. Masson.
Web sites