Universitat Internacional de Catalunya
Biomolecular Interaction
Other languages of instruction: Catalan, English
Teaching staff
Students can request an appointment with the lecturer by email: jvilla@uic.cat /
Martin Floor (mfloor@uic.es)
Introduction
Knowing how biomolecules interact opens the door for us to understand biological mechanisms of increasing complexity. In this course, after a brief introduction to the different experimental techniques of the study of interactions, we will use a purely bioinformatics approach to analyze the particularities of interactions of biomolecules, the study of existing databases and will end with the use of molecular simulations and docking to understand in more detail the biochemical and structural basis of these interactions.
Pre-course requirements
You need to have a good foundation in biochemistry and the ability to understand, develop and execute bioinformatics analysis tools based on Python and R.
Objectives
The central objective of this subject is to develop a holistic knowledge of the characteristics of the interactions between molecules of biological interest (proteins, nucleic acids, metabolites). In particular, in this course, we will seek:
- To know the importance of molecular interaction and be able to provide examples of different types of it.
- To know the main experimental methodologies used to study protein-protein interactions, as well as their virtues and limitations.
- To know and learn to use databases of molecular interactions
- To execute and understand simple molecular simulations and molecular docking methodologies
Competences/Learning outcomes of the degree programme
General:
- Team work and responsibility
- Ability to adapt to complex problems and to make informed decisions
Specific:
- To acquire ability to understand, to develop and to apply computational workflows to solve complex biological problems.
- To master data driven research.
- To develop skills for science communication in written and oral forms, making simple what is complex.
Learning outcomes of the subject
- Advanced knowledge of the use of the existing repertoire of protein interaction databases.
- Ability to develop computational tools in Python and R for the analysis of biomolecule interaction data.
- Ability to work in a team to produce and communicate scientific research.
Syllabus
The subject is divided into three modules:
Lectures:
- Biomolecule interaction:
- physicochemical fundamentals
- experimental techniques
- Molecular interaction databases
- Dynamics of molecular interactions
Laboratory:
- Molecular interaction databases
- The use of simulations in the study of molecular interactions
- Docking
PBL:
- Analysis and discussion of real examples of molecular interactions in biomedicine
Teaching and learning activities
In blended
The subject is divided into three main activities:
- Background sessions, based on sessions taught by the teacher.
- Practical sessions in which the development of computer tools will allow the completion of practical exercises to solve a problem.
- Problem-based learning sessions in which student teams will collectively develop a critical study of an issue.
The whole subject is based on a flipped classroom scheme, in which students will have to work to prepare the content for the next sessions and, in some cases, will have to present their learning to classmates in a collaborative and critical thinking project.
Evaluation systems and criteria
In blended
The evaluation will be based on the following items:
- Written exams:
- Partial: 15% of the final grade
- Final (including full course material): 25% of the final grade
- Completion of practical exercises: 30% of the final grade
- Presentation of the PBL group: 30% of the final grade
To pass the course the student must obtain a minimum grade of 5 in each of the items mentioned (Partial, Final, Practical Exercises and PBL). If the student does not reach the 5 points on items 1a and 1b, he can take a final multiple-choice exam on June 25 to improve his grades. There is no second chance for items 2 and 3.
Bibliography and resources
Structural Bioinformatics 2nd Edition Jenny Gu; Philip E. Bourne ISBN-10: 0470181052
Molecular Driving Forces: Statistical Thermodynamics in Biology, Chemistry, Physics, and Nanoscience, 2nd Edition; Ken A. Dill ISBN-10: 9780815344308
Protein-protein interactions : methods and applications. Edited by Haian Fu. Totowa, N.J.: Humana Press, 2004. xvi, 532. ISBN 1588291200.
Protein-ligand interactions : hydrodynamics and calorimetry : a practical approach. Edited by Stephen E. Harding - Babur Z. Chowdhry. 1st pub. Oxford: Oxford University Press, 2001. xxiv, 330. ISBN 0-19-963749-0.
Protein-ligand interactions : structure and spectroscopy : a practical approach. Edited by S. E. Harding - Babur Z. Chowdhry. 1st pub. Oxford: Oxford University Press, 2001. xxvi, 436. ISBN 0199637474.
Evaluation period
- E1 31/05/2021 I3 11:00h
- E2 28/06/2021 14:00h