Universitat Internacional de Catalunya
Cell Biology
Other languages of instruction: English
Teaching staff
Students may ask lecturers questions at the end of each class. For enquiries outside of class time, students must make an appointment by email:
• Coordinador: Dra Rut Fadó Andrés: rfado@uic.es
• Professors de magistrals (CM):
Dra Rut Fadó: rfado@uic.es
Dr. Martí Aldea mambmc@ibmb.csic.es
• Professor de casos (GD, ABPs and ApS):
Bárbara Samper: bsamper491@uic.es
• Profesors del Projecte Congrés:
Bárbara Samper: bsamper491@uic.es
Dra. Rut Fadó: rfado@uic.es
• Profesor d'autoaprenentatge online (exercisis):
Dra. Rut Fadó: rfado@uic.es
Sol·licitar cita per correu electrònic.
Introduction
The subject of Cellular Biology is studied during the first semester of second year of Medicine, corresponding to a pre-clinical period, where the student has already acquired a basic knowledge of the composition and structure of macromolecules, the structural and functional organization of the cells in subjects of the first year like Biochemistry and Molecular Biology.
At this point, this subject aims to expand the student's knowledge on cellular physiology, particularly in relation to the regulation of: the extra-and intracellular communication, cell cycle, cancer biology, developmental biology, cell death and specific functions of certain cell types, which together, provide to the student a good understanding of the structural and functional organization of the human body in normal and pathological situation.
In addition to the theoretical knowledge acquired in Cell Biology, this course is completed with practical training, as seminars and paper presentations, which allow to introduce students into the techniques, terminology and therapeutic approaches used in top level scientific research.
The coordinator of the subject during the course 20_21 is Dr Rut Fadó
The majority vehicular languages: Catalan and Spanish (some material, in english)
Pre-course requirements
Being a first-semester subject in the second year, the students must have previously coursed the subjects of Biochemistry, Molecular Biology and Introduction to Medical Genetics in the first year of Medicine. Therefore, to guarantee a good follow up and acquisition of the objectives is recommended that students have knowledge in:
- Biochemistry: Structure and properties of molecules and macromolecules (nucleic acids, proteins, carbohydrates and lipids)
- Cellular anatomy: structure and function of organelles
- Molecular biology: gene expression
- Transport through the plasma membrane
- Energetic metabolism: cellular respiration
- Genetics
- Techniques of Molecular and Cellular Biology
Furthermore, it is desirable that students have a good knowledge of English because many of the information sources are in this language.
Objectives
Show and providing the necessary tools to the students to understand and use in the future the theoretical content about: extra and intracellular communication, cellular cycle, cancer, the processes of mitosis, meiosis, gametogenesis and fertilization; the early stages of embryonic development at cellular level, cell death and neurodegeneration.
Show and providing the necessary tools to the students, through group work and seminars, to find, understand and communicate effectively structural and functional cellular mechanisms in relation to diseases, disorders and / or therapeutic strategies.
Providing the necessary tools to the students, through group work and supervised sessions, to understand, interpret and effectively communicate knowledge from scientific articles in top-level of Cellular Biology, get your own conclusions and form critical reasoning.
Competences/Learning outcomes of the degree programme
- 05 - Recognize own limitations and the need to maintain and upgrade professional skills, with particular emphasis on autonomous learning of new knowledge and skills and motivation for quality.
- 07 - Understand and recognise normal structure and function of the human body at the molecular, cellular, tissue, and organ and systemetic levels, at different stages of life and in both sexes.
- 09 - Understand and recognize the effects, mechanisms and manifestations of disease on the structure and function of the human body.
- 11 - Understand and recognize the effects of growth, development and aging on the individual and their social environment.
- 12 - Understanding the foundations for action, the indications and efficacy of therapeutic interventions, based on available scientific evidence.
- 23 - Communicate effectively and clearly, both orally and in writing with patients, family members, media and other professionals.
- 37 - Acquire basic training for research.
- CB-1 - To have acquired advanced knowledge and demonstrated, within the context of highly specialised scientific and technological research, detailed comprehension based on theoretical and practical aspects and a working methodology from one or more fields of study.
- CB-2 - To know how to apply and incorporate knowledge, an understanding of it and its scientific basis and the ability to solve problems in new and loosely defined environments, including multidisciplinary contexts that include both researchers and highly specialised professionals.
- CB-5 - To transmit in a clear and unambiguous way to a specialised or non-specialised audience, the results of scientific and technological research projects and innovation from the field of the most advanced innovation, as well as the most important concepts which they are based on.
- CTP-3 - To develop critical thinking and reasoning as well as self-assessment skills.
Learning outcomes of the subject
The objective of Cell Biology at the end of the course is that students will be able to:
· Explain the general processes of extra and intracellular communication.
· Identify the molecules involved in the intracellular signaling processes and their interrelations.
· Identify the molecules that participate in the control of the regulation of the cell cycle and its relation to the cancerous processes.
· Explain the process of formation of the embryo and the first phases of human embryonic development at the cellular and molecular level.
· Describe the mechanisms involved in cell death for necrosis, reticular stress, autophagy and apoptosis.
· Understand and use the scientific terminology used in the field of Biochemistry, Cellular and Molecular Biology.
· Search, organize and communicate scientific and health information.
Syllabus
The subject of Cellular Biology is divided into 5 distributive blocks:
Block 1: Extra and intracellular communication
Introduction. Cellular biology techniques
Communication between cells
Ligand-Receptor
Signaling pathways activate by GPCR
Signaling pathways activate by TRK and associated to TRK
Other signaling pathways
Block 2: Cell Cycle and Cancer Biology
The cell cycle: replication of complex systems
Cell cycle entry: from Michaelis-Menten to molecular switches
Molecular events, checkpoints and cycle exit
Proliferation and growth: towards 3D tissue engineering
Cancer, DNA damage signaling and subversion
Block 3. Early embrionic developmental biology
General characteristics
Gametogenesis
From zygot to gastrula
From gastrula to fetus
Block 4. Cell death and degeneration
Cell Death
Apoptosis
Neurodegeneration and Alzheimer
Congress of Cellular Biology
Poster session
Oral communications
Plenary session
Cases in divided groups (GD) and Problem Based Learning (ABPs)
Techniques applied to the diagnosis. X-Fragile Syndrome. Optogenetics applied to blindness. Retinitis pigmentosa. EDCs. Prions. The case of thalidomide. Alterations in BRCA1. Aging. Cancer and immunotherapy. Regeneration. Spina bifida. Edition with CRISPR. Gene therapy
Congress project and social learning (ApS)
Feeding the brain: the effect of nutrients on learning and memory
Teaching and learning activities
In blended
1) Lectures (CM; online):
The content is theoretical.
They are complemented by exercises and self-learning material posted in the Moodle space.
They are worked during the course in a single group.
2) Clinical cases and Problem-based Learning (GD and ABP; presencial, if the health situation allows it):
The contents are practical and relate cellular processes explained in the lectures with pathologies and / or therapeutic strategies.
It consists of working on a case proposed by the teacher (available in the Moodle space). In the case of the GD, the student participates in the classes looking for information on the topics proposed by the teacher and discussing the results of this activity with the rest of the classmates. In the case of the ABPs, the student presents the subject proposed by the teacher in small groups in the form of a seminar (with the bibliography recommended, available in the Moodle space) and discusses with the other classmates the results of this activity. In both cases, the most significant learnings are brought together at the end.
They are worked in small groups.
3) Congress of Cellular Biology (in blended) and Social Learning (ApS; in blended):
It consists of working on a current topic of cell biology in a conference format, with scientific articles, tutored sessions, a poster session, oral communications and a plenary lecture.
A research article (available in Moodle) is proposed to be presented in a poster format (all groups) and in oral communication format (3 groups).
The teaching material will be delivered mainly in the English language.
The same topic of the Congress will be used to do a social learning activity (AsP). Students will carry out an educational action through social networks (Tiktok, Instagram, Twitter, YouTube, WhatsApp or Facebook) aimed at the rest of the educational community and their families.
4) Online self-learning:
Self-assessment problems and exercises (summative evaluation).
Tests type tests at the end of all the thematic blocks in the Moodle space (formative evaluation; it is not part of the evaluation systems).
Evaluation systems and criteria
In blended
20% Continuous evaluation
45% Final exam
20% Congress
5% Attendance to GD and ABPs
10% ABPs and ApS
The exam consist of, at least, 1 question per lecture, GD, ABPs or Congress and ApS; divided in one part with multiple choice questions, 4 answer options and only one correct one (the correct sum + 1 and the remaining errors -0.33); and other part with short questions. 10% of the questions may be based on concepts not explained in class but present in the material available in Moodle.
The attendance to the poster’s tutoring sessions is mandatory. Up to 0.5 points on the Congress’ grade can be added to the students that ask a question during the plenary session. Up to 0.5 points on the final grade of the subject can be added to the students of the 3 best groups of posters (only in the 1st call).
Attendance at GD, ABPs and ApS sessions is mandatory (at least to 12 of the 16 sessions in order to calculate the final grade of the subject). To obtain the final grade, you need at least 5 points in the learning activities, except in the mid-term exam. In group work activities, the attendance, participation, knowledge and competency grades will be individual. The grades of ABPs, ApS and Congress, once passed, can be applied in future calls; at the request of the student, it is possible to attend again in following courses.
Bibliography and resources
- Alberts B, et al. Molecular Biology of the cell. 6th edition Garland Science, 2015.
- Lodish H, et al. Molecular Cell Biology. 7th edition Macmillan Learning, 2013 (8th edition, 2016).
- Nelson DL, Cox MM. Lehninger Principles of Biochemistry. 6th edition Macmillan Learning, 2013 (7th edition, 2017).
- Sadler TW, Langman, embriología médica. 13ª edició Wolters Kluwer, 2016
- Carlson BM, Human Embryology and Developmental Biology, 5th edition Elsevier/Saunders, 2014
Evaluation period
- E1 12/01/2021 09:00h
- E2 08/07/2021 11:30h