Directory
BOSCH PITA, Miguel
BOSCH PITA, Miguel
CV
Professor Col.laborador
Basic Areas, DEPARTMENT OF BASIC SCIENCIES. Universitat Internacional de Catalunya
- Neurociències Universitat de Barcelona
- Bioquímica Universitat de Barcelona
Estic interessat en els mecanismes moleculars de l'aprenentatge i la memòria, i en el seu deteriorament en malalties neurodegeneratives i psiquiàtriques. La meva recerca pretén entendre com s'emmagatzema la informació al sistema nerviós, des de la sinapsi individual fins a la xarxa neuronal. Un aspecte clau de la meva recerca és l'ús de tecnologies avançades basades en la llum, com ara la microscòpia multifotònica, l'optogenètica i la fotofarmacologia. Desenvolupo nous mètodes i aplicacions d'aquestes tecnologies per visualitzar i manipular, en temps real, els esdeveniments de plasticitat neuronal a múltiples nivells: circuits (per exemple, ones cerebrals), neurones, i sinapsis individuals (per exemple, potenciació i depressió a llarg termini). A més aplico aquests mètodes per desenvolupar fototeràpies basades en fotofarmacologia per a malalties com els trastorns de l'espectre autista i l'epilèpsia.
Education
Licenciatura en Bioquímica, Universitat de Barcelona
Professional experience
- Current positions: Assistant Professor (UIC-Barcelona, since Sep 2020);
Group Leader of the Laboratory of Synaptic Plasticity (since Jan 2021)
Associate Researcher (INc-UAB, since Jan 2022).
- Associate Researcher, laboratory of M.V. Sánchez-Vives, Systems Neuroscience, Biomedical
Research Institute “Agustí Pi i Sunyer” (IDIBAPS), Barcelona, Spain (May 2018-Jan 2021).
- MSCA Researcher, laboratory of Pau Gorostiza, Nanoprobes and Nanoswitches Lab, Institute
for Bioengineering of Catalonia (IBEC), Barcelona, Spain (Mar 2015-Apr 2018).
- Research Scientist, laboratory of Mark F. Bear, The Picower Institute for Learning and Memory,
Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. (May 2012-Sep 2014).
- Visiting Research Scientist, laboratory of Yasunori Hayashi, Brain Science Institute (BSI),
RIKEN, Wako, Japan (short stays: Sep-Dec 2010 and Jan-Apr 2012).
- FRAXA Postdoctoral Fellow, Mark F. Bear Lab, The Picower Institute for Learning and Memory,
Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. (Aug 2009-Apr 2012).
- “Beatriu de Pinós” Postdoctoral Fellow, laboratory of Yasunori Hayashi, RIKEN-MIT
Neuroscience Research Center, The Picower Institute for Learning and Memory,
Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (Des 2005-Jul 2009).
- Postdoctoral Associate, laboratory of Tetsuo Yamamori, Division of Brain Biology, National
Institute for Basic Biology (NIBB), Okazaki, Japan (May-Nov 2005).
- Ph.D. in Neuroscience. Dept. of Cell Biology and Pathological Anatomy, Medical School,
University of Barcelona (UB), Barcelona, Spain (Aug 2000-Apr 19th 2005). Supervisors: Jordi
Alberch and Josep M. Canals. Thesis title: Cell therapy in models of Huntington's disease.
- Pre-doctoral internship, laboratory of Ernest Arenas, Medical Biochemistry and Biophysics
Department, Karolinska Institute (KI), Stockholm, Sweden (Aug–Nov 2002).
- B.S. in Biochemistry. Faculty of Biology, Faculty of Chemistry, University of Barcelona (UB),
Barcelona, Spain (Feb 2000).
- Undergraduate internships: 1) Antonio Zorzano Lab, Dept. of Biochemistry and Molecular
Biology, University of Barcelona, Barcelona, Spain (Apr-Jun 2000); 2) Jordi Bernués Lab,
Dept. of Cellular and Molecular Biology, Institute of Molecular Biology of Barcelona (IBMB),
CSIC, Spain (Oct 1999 – Feb 2000); 3) Marta Cascante Lab, Dept. of Biochemistry and
Molecular Biology, University of Barcelona, Barcelona, Spain (Jul-Aug 1997; Jul-Aug 1998).
Publications
- Camassa, A.; Barbero-Castillo, A.; Bosch, M.; DaSilva, M.; Masvidal, E.; Villa, R.; Guimera-Brunet, A.; Sanchez-Vives, M., (2024), "Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states", Nanoscale Horizons, ISSN: 2055-6756.
- Ortega-Gascó, A.; Parcerisas, A.; Hino, K.; Herranz, V.; Ulloa, F.; Elias, A.; Bosch, M.; García, J.; Simó, S.; Pujadas, L.; Soriano, E., (2022), "Regulation of adult neurogenesis and neuronal differentiation by Neural Cell Adhesion Molecule 2 (NCAM2)", bioRxiv.
- Mendoza, M.B.; Gutiérrez, S.; Ortiz, R.; Moreno, D.; Dermit, M.; Dodel, M.; Rebollo, E.; Bosch, M.; Mardakheh, F.K.; Gallego, C., (2021), "The elongation factor eEF1A2 controls translation and actin dynamics in dendritic spines", Science Signaling, vol. 14, No. 691, ISSN: 1945-0877.
- Parcerisas, A.; Ortega-Gascó, A.; Hernaiz, M.; Odena, M.; Ulloa, F.; De Oliveira, E.; Bosch, M.; Pujadas, L.; Soriano, E., (2021), "New partners identified by mass spectrometry assay reveal functions of NCAM2 in neuronal cytoskeleton organization", International Journal of Molecular Sciences, vol. 22, No. 14, ISSN: 1422-0067.
- Gomila , A.; Rustler, K.; Maleeva, G.; Nin-Hill, A.; Wutz, D.; Bautista, A.; Rovira, X.; Bosch, M.; Mukhametova, E.; Petukhova, E.; Ponomareva, D.; Mukhamedyarov, M.; Peiretti, F.; Alfonso, M.; Rovira, C.; König, B.; Bregestovski, P.; Gorostiza, P., (2020), "Photocontrol of endogenous glycine receptors in vivo", Cell Chemical Biology, vol. 27, No. 11, pp. 1425-1433, ISSN: 2451-9448.
- Thomazeau, A.; Bosch, M.; Essayan-Perez, S.; Barnes, S.; de Jesús-Cort́es, H.; Bear, M.F., (2020), "Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice", Molecular psychiatry, ISSN: 1359-4184.
- Cabré, G.; Garrido-Charles, A.; Moreno, M.; Bosch, M.; Porta, M.; Krieg, M.; Gascón, M.; Camarero, N.; Gelabert, R.; Lluch, J. M.; Busqué, F.; Hernando, J.; Gorostiza, P.; Alibés, R., (2019), "Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation", Nature communications, vol. 10, No. 1, ISSN: 2041-1723.
- Pittolo, S.; Lee, H.; Lladó, A.; Tosi, S.; Bosch, M.; Bardia, L.; Gómez, X.; Llebaria, A.; Soriano, E.; Colombelli, J.; Poskanzer, K.; Perea, G.; Gorostiza, P., (2019), "Reversible silencing of endogenous receptors in intact brain tissue using two-photon pharmacology", PNAS - National Academy of Sciences. Proceedings (Online), vol. 116, No. 27, pp. 13680-13689, ISSN: 1091-6490.
- Borovac, J.; Bosch, M.; Okamoto, K., (2018), "Regulation of actin dynamics during structural plasticity of dendritic spines: signalling messengers and actin-binding proteins", Molecular and cellular neuroscience, vol. 91, pp. 122-130, ISSN: 1044-7431.
- Bosch, M.; Castro, J.; Saneyoshi, T.; Matsuno, H.; Sur, M.; Hayashi, Y., (2014), "Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-term Potentiation", NEURON, vol. 82, No. 2, pp. 444-459, ISSN: 1097-4199.
- Huang, Z.; Zhang, X.; Bosch, M.; Smith, S.; Lippard, S., (2013), "Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc", Metallomics, vol. 5, No. 6, pp. 648-655, ISSN: 1756-591X.
- Bosch, M.; Hayashi, Y., (2012), "Structural Plasticity of Dendritic Spines", CURRENT OPINION IN NEUROBIOLOGY, vol. 22, No. 3, pp. 383-388, ISSN: 1873-6882.
- Hayashi, Y.; Bosch, M.; Hosokawa, T.; Liu, P.; Saneyoshi, T., (2024), "Molecular mechanisms underlying synaptic tagging and consolidation", Synaptic tagging and capture.
- Bosch, M., (11/12/2016), "Photomarking Relocalization Technique for Correlated Two-Photon and Electron Microcopy Imaging of Single Stimulated Synapses", Synapse Development: Methods in Molecular Biology., pp. 185-214. ISBN: 978-1-4939-6688-2.
- Bosch, M., (27/01/2012), "Roles of neuronal activity-induced gene products in Hebbian and homeostatic synaptic plasticity, tagging and capture", Synaptic plasticity. Dynamics, development and disease, pp. 335-354, Springer, Vienna. ISBN: 978-3-7091-0932-8.
Activities
- FENS FORUM OF NEUROSCIENCE Presentació de poster "Photoactivation of individual synapses in vivo with covalent photoswitches targeting endogenous glutamate receptors", 2022.
- Congreso de la Sociedad Española de Neurociencia Ponència "Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wildtype and fragile X model mice", 2021.