Subject

Cell Therapy

  • code 13567
  • course 3
  • term Semester 2
  • type OB
  • credits 6

Module: ADVANCED TRAINING

Matter: MEDICINE III

Main language of instruction: English

Other languages of instruction: Catalan, Spanish

Timetable
group M
 Sem.2  WE 12:00 14:00 P2A03
 Sem.2  FR 12:00 14:00 P2A03

Teaching staff

Head instructor

MsU Yolanda Jacoba DE ROO - yjderoo@uic.es

Other instructors

Dra. Begoña María BOSCH - bbosch@uic.es

Office hours

Please send an email to set up a meeting: 

Yolanda de Roo: yjderoo@uic.es  

Begoña Bosch: bbosch@uic.es

Introduction

The course of Cellular therapy explains how different cell types can be employed as curative or regenerative therapy. Different stem cells and their functions will be explained in the context of their tissue. Also, cellular modification strategies with the objective to realize a cellular differentiation of interests will be part of the course. Finally, advances related to the Bioengineering field, such as how biomaterials aid in improving cellular therapy with a better clinical result will be discussed.

Pre-course requirements

Cellular and molecular Biology

Biomaterials and Biocompatibility

Tissue engineering

Objectives

-      Know different cell types which are able to be used in cell therapy

-      Understand the cellular reprogramming strategies

-      Familiarize with the different techniques to obtain the cells of interest 

-      Known the limitations of cell therapy

-      Know the different applications of biomaterials in cell therapy approaches

-      Interpret scientific papers of different areas and define a better strategy

Competences / Learning outcomes of the degree programme

  • CB1 - Students must demonstrate that they have and understand knowledge in an area of study based on general secondary education. This knowledge should be of a level that, although based on advanced textbooks, also includes some of the cutting-edge elements from their field of study.
  • CB2 - Students must know how to apply their knowledge to their work or vocation in a professional way and have the competences that are demonstrated through the creation and defence of arguments and the resolution of problems within their field of study.
  • CB3 - Students must have the ability to bring together and interpret significant data (normally within their area of study) and to issue judgements that include a reflection on important issues that are social, scientific or ethical in nature.
  • CB4 - Students can transmit information, ideas, problems and solutions to specialist and non-specialist audiences.
  • CE16 - To apply specific Bioengineering terminology both verbally and in writing in a foreign language.
  • CG10 - To know how to work in a multilingual and multidisciplinary environment.
  • CG3 - To be able to learn new methods and theories and be versatile so as to adapt to new situations.
  • CG4 - To resolve problems based on initiative, be good at decision-making, creativity, critical reasoning and communication, as well as the transmission of knowledge, skills and prowess in the field of Bioengineering
  • CT3 - To know how to communicate learning results to other people both verbally and in writing, and well as thought processes and decision-making; to participate in debates in each particular specialist areas.
  • CT5 - To use information sources in a reliable manner. To manage the acquisition, structuring, analysis and visualisation of data and information in your specialist area and critically evaluate the results of this management.
  • CT6 - To detect gaps in your own knowledge and overcome this through critical reflection and choosing better actions to broaden your knowledge.
  • CT7 - To be fluent in a third language, usually English, with a suitable verbal and written level that is in line with graduate requirements.

Learning outcomes of the subject

When finalizing this course, the student will be able to: 

-      Interpret research and clinical cases related to cell therapy

-      Understand cellular modulation strategies and how biomaterials improve their action

-      Develop a critical opinion and be able to defend it through an oral presentation

Syllabus

CLASSICAL CELL THERAPY

  1. Introduction to cell therapy
  2. Stem cells: general aspects and types
    1. Hematopoietic stem cells: Principal use and harvesting techniques. 
    2. Mesenchymal stem cells: principal use and harvesting techniques
    3. Pluripotent stem cells: principal use and harvesting techniques
    4. Other types of stem cells: Fat, umbilical cord, amniotic fluid, placenta etc. 
    5. Genetic editing: Strategies and techniques

BIOMATERIALS AND CELL THERAPY

  1. Biomaterials and cell therapy
  2. Applications of biomaterials in cell therapy
    1. Muscle tissue
    2. Bone tissue
    3. Cardiac tissue
    4. Dermal tissue
    5. Ocular tissue
    6. Personalized cell therapy

 

Project: Applied case on cell therapy

The student will receive 3 scientific papers with specific cases (1 review, 1 clinical paper and 1 technological paper). The student will have to present a summary on the 3 papers though a critical study of the content and suggest a better strategy for cell therapy approach. 

Teaching and learning activities

In person

The course will be given with theoretical lectures and with presentation of student projects. In the theoretical lectures, all the concepts of cell therapy will be explained and also the application of this typo of therapy in the regeneration of different tissues. The presentations will be given by the students about their conceptual understanding of an actual cell therapy approach. 

Evaluation systems and criteria

In person

First sitting: 

1)   Midterm exam: 20%

2)   Project: 20%

3)   Final exam: 60%

 

Second sitting: The same evaluation criteria will be applied in the second sitting of the exam, without the possibility of obtaining a distinction with honors. 

  

Important considerations: 

  1. Plagiarism, copying or any other action that may be considered cheating will be
    zero in that evaluation section. Besides, plagiarism during exams will mean the immediate failing of the whole subject.
  2. Changes of the calendar, exam dates or the evaluation system will not be accepted. 
  3. A minimal mark of 4,5 should be obtained in the final exam to pass the course.
  4. Exchange students (Erasmus and others) or repeaters will be subjected to the same conditions as the rest of the students.

Bibliography and resources

  • Stem Cells and Cell Therapy. Mohamed Al-Rubeai, Mariam Naciri. Springer Netherlands (2013). ISBN: 9400771959, 9789400771956.
  • Cell Therapy: Current Status and Future Directions. Dwaine F. Emerich, Gorka Orive. Springer (2017). ISBN: 3319571532, 9783319571539.

Evaluation period

E: exam date | R: revision date | 1: first session | 2: second session:

  • E1 27/05/2020 10:00h
  • E2 26/06/2020 12:00h
  © 2024 Universitat Internacional de Catalunya | Contact us | Privacy and data protection | Intellectual property
  Campus Barcelona. Tel.: 93 254 18 00 | Campus Sant Cugat. Tel.: 93 504 20 00