Subject

Human Biology 2

  • code 07871
  • course 1
  • term Semester 1
  • type FB
  • credits 6

Module: Basic biomedical sciences relevant in dentistry

Matter: Genetics, Biochemicals and Molecular Biology

Main language of instruction: Spanish

Other languages of instruction: Catalan, English

If the student is enrolled for the English track then classes for that subject will be taught in the same language.

Teaching staff

Head instructor

Dr. Miguel BAENA - mbaena@uic.es
Dr. Ricky Shantilal JOSHI - rjoshi@uic.es

Office hours

Dr. Ricky S. Joshi (rjoshi@uic.es)

Dr. Miguel Baena (mbaena@uic.es)

Introduction

In the event that the health authorities announce a new period of confinement due to the evolution of the health crisis caused by COVID-19, the teaching staff will promptly communicate how this may effect the teaching methodologies and activities as well as the assessment.

The aim of this subject is to introduce students to the main molecular bases of cellular communication. To understand the behaviour of the cells as non-isolated units integrated in tissue, it is essential to know what happens in their interior and how this activity is influenced by the surrounding medium.

To this end, the students must know the cellular components, the transport mechanisms that regulate cell content, the signalling pathways that control mechanisms such as cell growth and proliferation, and the processes that can be triggered when this regulation is lost, such as in cancer. The final section of this subject, entitled "oral biology", goes deeper into those aspects of biochemistry and molecular and cell biology which directly affect dental practice as well as the understanding of the normal and pathological workings of the organs affected. In order to introduce to and familiarise the students with scientific research applied to dentistry, they will carry out a work of critical reading and understanding of a scientific paper, which will be presented at the end of the semester in the form of a poster.

Related to this same objective, the course includes several practical sessions where the students will be introduced to, and carry out, some of the techniques used in both diagnosis and current biomedical research.

Pre-course requirements

Knowledge of Biology and Biochemistry at sixth-form level.

Objectives

Knowledge:

The aim of this course is to go deeper into the biochemical and molecular aspects upon which knowledge in any area of the health sciences is based.

On finishing this course, the student must know:

-The mechanism of communication between cells, the transmission of cellular signals, the molecular bases of division and cell death, and the biological mechanisms involved in cancer.

-The structure and composition of dental tissues.

-The basic principles that determine the inheritance of diseases affecting the oral and dental environment. 

Intellectual and practical skills: 

-Become familiar with the scientific method. 

-Promote reasoning and the discussion of problems. 

-Integrate knowledge into practical laboratory tasks. 

-Know the main sources of information and resources available to update the knowledge acquired. 

Attitude: 

This is the only semester in which the student will take a compulsory subject of Biochemistry and Molecular Biology. It is therefore intended that the student, upon finishing this subject, has understood the importance of this area of knowledge in the development of the other subjects of the degree and the Health Sciences in general, since any pathology of living beings is defined ultimately at the biochemical and molecular level.

Competences / Learning outcomes of the degree programme

  • 11 - Understanding the basic biomedical science Dentistry is based on in order to ensure that adequate dental healthcare is provided.
  • 08 - Knowing how to share information with other healthcare professionals and how to work as part of a team.
  • 12 - Understanding and recognising the structure and normal function of the stomatognathic apparatus, at a molecular, cellular, tissue and organic level, during the various stages of life.
  • 14 - Being aware of the general processes of the illness, including infection, inflammation, alterations in the immune system, degeneration, neoplasm, metabolic alterations and genetic disorders.
  • 18 - Being aware of, critically evaluating and knowing how to use sources of clinical and biomedical infomation in order to obtain, organise, interpret and communicate scientific and healthcare-related information.
  • 19 - Being aware of scientific methods and having the critical ability to evaluate established knowledge and innovative information. Being able to formulate hypotheses, collect and critically evaluate information in order to resolve problems, in accordance with scientific methods.
  • 33 - Knowing the morphology and function of the stomatognathic apparatus, including material on embriology, anatomy, histology and specific physiology
  • 34 - Knowing about scientific methods and having the critical ability to evaluate established knowledge and new information
  • 38 - Being aware of clinical and laboratory-based procedures and diagnostic tests, knowing their reliability and diagnostic viability and being competent in interpreting the results

Learning outcomes of the subject

  • 1.04 - Know the organization of our immune system: molecules, cells and organs
  • 1.09 - - Know the structure and function of communication and control systems, nervous system and endocrine
  • 1.10 - Know the structure and function of the organs and systems involved in maintaining the homeostasis of the human body. Circulatory, respiratory, digestive and urinary apparatus.
  • 1.19 - Solve clinical problems from deductions made from the basic knowledge of anatomy and physiology of the head and neck
  • 1.25 - Know the different tissues that make up the teeth, distribution and histologic features.
  • 1.30 - Understand the basic bio-medical sciences on which dentistry is based to ensure proper oral-dental care.
  • 1.31 - - Understand and recognize the structure and normal function of the stomatognatic apparatus at a molecular and cellular level
  • 1.32 - Will know the general processes of falling ill, including genetic alterations
  • 1.33 - Will know better the scientific method and will have critical capacity to assess the established knowledge and new information
  • 1.34 - Will get the rudiments to assess published basic research
  • 1.35 - Will manage better than at the beginning of the subject, contemporary information technologies
  • 1.36 - – Will know genetic diagnostic testing of laboratory, its reliability and diagnostic validity and begin to be able to interpret the results
  • 1.37 - Will value as necessary the knowledge throughout life
  • 1.38 - Will start to understand the biochemical behavior of the essential bio-materials for dental practice
  • 1.39 - Will learn the general processes of falling ill, including metabolic alterations.
  • 1.40 - Will know the clinical biochemistry tests, its reliability and diagnostic validity and begin to be able to interpret their results

Syllabus


Chapter 1 MOLECULAR TECHNIQUES

Chapter 2 CELLULAR STRUCTURES

Chapter 3 CELL CYCLE

Chapter 4 CELLULAR TRANSPORT

Chapter 5 CELLULAR SIGNALLING

Chapter 6 CYTOSKELETON

Chapter 7 EXTRACELLULAR MATRIX

Chapter 8 INHERITANCE

Chapter 9 STEM CELLS AND CANCER

Chapter 10 ORAL BIOLOGY

Teaching and learning activities


In blended

The contents of the course will be taught through the following activities:

-The presentation of theory to all students in one group.
-Research work based on scientific literature: the student will be provided with a publication based on research in the field of dentistry. Students, in groups, must read, understand and make a poster to present the main results described in the publication, accompanied by an oral presentation.
-Practical sessions: guided laboratory sessions in which students will put into practice the knowledge acquired in lectures with regard to the most common techniques in a Biochemical laboratory.

In the case of the blended teaching system, the students will be divided into two groups, alternating between face-to-face attendance at the classes with online monitoring of them.

In laboratory practices, since the groups will be formed by a reduced number of students, all the sessions will be presentially.

Evaluation systems and criteria


In blended

Progress test: 10% of the final grade

Scientific poster: 20% of the final grade

Practical laboratory sessions: 10% of the final grade. The practical sessions are compulsory

Final exam: 60% of the final grade. A minimum grade of 5 is needed to make average with the other parts of the subject.

It will be the evolution of the pandemic caused by the Covid-19 that determines whether the completion of the partial and final exams will be in person or through an online questionnaire, in which students will be monitored to ensure that the exam passes under normal conditions.

Bibliography and resources

• ESSENTIAL CELL BIOLOGY. Alberts. B. et al. 4th edition.

 PRINCIPLES OF BIOCHEMISTRY. Lehninger. et al. 5th edition.

• THE CELL: A Molecular Approach. Cooper. G.M. et al. 6th Edition.

• MOLECULAR CELL BIOLOGY. Lodish. H et al. 5th edition.

Evaluation period

E: exam date | R: revision date | 1: first session | 2: second session:

  • E1 07/01/2021 12:00h A01
  • E1 07/01/2021 12:00h A02
  • E1 07/01/2021 12:00h A15
  • E1 07/01/2021 12:00h A03
  • R1 27/01/2021 13:30h A04
  • E2 30/06/2021 10:30h A22
  • E2 30/06/2021 10:30h A21
  • R2 07/07/2021 12:00h A16
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