Questions will be answered in person with the involved instructor. Questions will not be answered by mail.
To make an appointment:
Microbiology:
Jordi Mas (jmas@uic.es)
Immunology
Natalia Ricco (anricco@uic.es)
Introduction
In the event that the health authorities announce a new period of confinement due to the evolution of
the health crisis caused by COVID-19, the teaching staff will promptly communicate how this may effect
the teaching methodologies and activities as well as the assessment.
Microbiology and immunology, from the point of view of a health professional,are two sides of the same coin. The first is dedicated to the study of a broad group of living organisms with which we coexist and establish different degrees of interactions. In addition to economic reasons, we will focus in the ability of many microorganisms to cause diseases in humans. The immunology, on the other hand, deals with the mechanisms disposed by the human body to protect against the infections caused by, among others, the microorganisms.
Pre-course requirements
Students must have a previous knowledge in biochemistry, human genetics, molecular biology, cellular biology. The student`s access route assures the basic knowledge needed to follow the present subject.
Objectives
The first goal of this subject is to provide the student with knowledge about the characteristics and peculiarities of a broad variety of organisms with which we establish a number of steady interactions as well as the benefits and damages that can be determined by then. Special interest will of course be given to oral microbiology.
As important as the former goal is to provide structural and functional overview of the immune system, both in health and disease conditions, again focusing in the special immunological characteristics of the mouth and the oral cavity.
The last goal of this subject is to show the student the most relevant techniques and processes employed in this scientific fields in order to provide a critical capacity useful for the latter professional career.
Competences / Learning outcomes of the degree programme
14 - Being aware of the general processes of the illness, including infection, inflammation, alterations in the immune system, degeneration, neoplasm, metabolic alterations and genetic disorders.
32 - Knowing the biomedical science on which Dentistry is based in order to ensure adequate oral and dental care. This science must include material on: (a). Embryology, anatomy, histology and the physiology of the human body (b). Genetics, Biochemistry, Cell and Molecular Biology and (c). Microbiology and immunology.
35 - Knowing the scientific principles of sterilisation, disinfection and the antiseptics necessary to prevent cross-infection in dental practice
07 - Promoting new knowledge and techniques being acquired through autonomous learning, as well as the motivation to achieve quality.
11 - Understanding the basic biomedical science Dentistry is based on in order to ensure that adequate dental healthcare is provided.
18 - Being aware of, critically evaluating and knowing how to use sources of clinical and biomedical infomation in order to obtain, organise, interpret and communicate scientific and healthcare-related information.
Learning outcomes of the subject
Knowledge and understanding of the microbiotic world in terms of existence, history diversity and characteristics.
Knowledge of the most common infectious diseases determined by the different types of microorganisms.
Knowledge on the different tools for control of microorganisms' growth and the infections determined by then.
Knowledge of the economical and scientific relevance of microorganisms
Knowledge of the basic techniques on how to handle and interpret microbiological data
Knowledge on the structure and function of the immune system both in health and disease conditions
Knowledge on the transfer to the human healthcare of the advances in the field of the immunology.
Dysfunction of the immune system
Interpretation of the clinical information related to the immune system.
Knowledge of scientific vocabulary in English and Spanish in the field of Immunology
1.01 - Know the different types of microorganisms that interact with the human body
1.02 - Know the most common infectious diseases and the pathogens that cause them
1.03 - Diagnose, treat and prevent the most common infections in dentistry
1.04 - Know the organization of our immune system: molecules, cells and organs
1.05 - Manage with immunology infections and tumors, as well as auto-immunity
1.06 - Understand and describe the embryological origin of human
1.12 - Solve clinical problems from deductions made with the basic knowledge of anatomy and physiology of the human body
1.32 - Will know the general processes of falling ill, including genetic alterations
1.33 - Will know better the scientific method and will have critical capacity to assess the established knowledge and new information
1.34 - Will get the rudiments to assess published basic research
1.36 - – Will know genetic diagnostic testing of laboratory, its reliability and diagnostic validity and begin to be able to interpret the results
1.37 - Will value as necessary the knowledge throughout life
1.39 - Will learn the general processes of falling ill, including metabolic alterations.
1.40 - Will know the clinical biochemistry tests, its reliability and diagnostic validity and begin to be able to interpret their results
Syllabus
Immunology
Unit 1. Description of the immune system: Immune system the sixth sense, structure and function of the immune system: organs, cells and molecules.
Unit 2. The innate part of the immune system: the complement system, the macrophage
Unit 3. The adaptive part of the immune system: antigens and antigen presentation, the MHC / HLA system
Unit 4. The adaptive part of the immune system: T and B lymphocyte, diversity in the immune system
Unit 5. The immune system in action: immunity against microorganisms, immunity against tumors.
Unit 6. The immune system in action: immunity from transplants, vaccines.
Unit 7. Dysfunctions of the immune system: immune tolerance, immunodeficiencies.
Unit 8. Dysfunctions of the immune system: autoimmunity, hypersensitivity
Unit 1. Introduction to Microbiology: definition and overview, brief history, key figures, oral microbiology today. Unit 2. I Analysis and microbiological diagnosis (laboratory techniques): standard microbiological practices, antigen detection, identification of microorganisms, technical-omics (genomics, proteomics ...) Unit 3. Laboratory techniques: control of microbial growth, sterilisation. Unit 4. Morphology and bacterial surface structures: cytoplasmic membrane wall bacterial outer membrane of Gram negative bacteria, capsule Unit 5. Bacterial appendices, extracellular products and intracellular structures: mobility flagella, fimbriae and pili, toxins, bacterial spores, organelles of eukaryotic microorganisms Unit 6. Bacterial metabolism: an overview of bacterial metabolism, energy generation pathways, culture media, main metabolic characteristics of oral bacteria Unit 7. Specific microbial genetics: generation of genetic variability, conjugation, transposition, transformation. Genome projects. Unit 8. Virology: general characteristics of viruses and viral replication, virus quantification Unit 9. Main families of viruses: bacteriophage and human pathogenic viruses Unit 10. Health microbiology: microbial pathogenicity, microorganism-person relationship, transmission of microorganisms. Unit 11. Introduction to bacterial taxonomy: bacterial species concept, classification of bacteria Unit 12. Major families of bacteria: taxonomic characteristics of oral bacteria Unit 13. Microbial diversity: fungi and parasites oral Interest Unit 14. Oral Microbiology of dental plaque, caries. Unit 15. Periodontal, endodontic and peri-implant microbiology and processes.
Problem based learning:
Vaccines
Immunology of transplants & implants
Pregnancy immunology
Immunomodulation
Oral microbiology
Massive sequencing
Scientific papers
Teaching and learning activities
Evaluation systems and criteria
Bibliography and resources
Basic Immunology: Functions and Disorders of the Immune System A.K. Abbas, A.H. Lichtman, S. Pillai. Elsevier Ed. 4ª ed. 2014
Inmunobiología: el sistema inmunitario en condiciones de salud y de enfermedad. Janeway et al. Ed. Masson 7ª ed. 2009.
Microbiología Estomatológica: Fundamentos y guía práctica (3ª edición). Marta Negroni. Ed Médica. Panamericana
Brock. Microbiología de los microorganismos. M.T. Madigan, J.M. Martinko y J. Parker. 10ª Ed. Prentice Hall.1999.
Microbiología. Prescott, Harley y Klein. McGraw-Hill 7ª Ed, 2008.
Microbiología Médica. P.R. Murray, K.S. Rosenthal y M.A. Pfaller. 7ª Ed. Elsevier Science. 2013
Sherris. Microbiología Médica. Una introducción a las Enfermedades Infecciosas. K.J. Ryan y C.G. Ray editores. 4ª Ed. McGraw-Hill Interamericana. 2004.
Evaluation period
E: exam date | R: revision date | 1: first session | 2: second session: