Directori

BIGAS SALVANS, Anna

Departament de Ciències Bàsiques

BIGAS SALVANS, Anna

CV

Perfil del professor

Ciències Bàsiques, DEPARTAMENT DE CIÈNCIES BÀSIQUES. Universitat Internacional de Catalunya

Formació acadèmica

Doctora Ciencias Biológicas, Universitat de Barcelona
Llicenciada en Ciències Biològiques, Universitat de Barcelona

Experiència professional

Coordinator and Group Leader Program in Cancer Research, Research Institute Hospital del Mar (IMIM)
March2020-now Scientific Director CIBERONC CIBER, Spain
2000-2008 Researcher (Senior Group leader) Department of Molecular Oncology, IDIBELL, Barcelona, Spain
1997-2000 Researcher (Junior Group leader) Department of Cell Therapy, Institut Recerca Oncològica, Barcelona, Spain
1993-1997 Research Fellow Fred Hutchinson Cancer Research Center, Seattle, USA. Mentor: Irwing D. Bernstein and Laurie A Milner
1989-1992 Ph. D. student, Fundació Investigació Sant Pau (FISP). University of Barcelona
Publications:
Marruecos L, Bertran J, Guillén Y, González J, Batlle R, López-Arribillaga E, Garrido M, Ruiz-Herguido C, Lisiero D, González-Farré M, Arce-Gallego S, Iglesias M, Nebreda AR, Miyamoto S, Bigas A*, Espinosa L* (*corresponding). Ikba deficiency imposes a fetal phenotype to intestinal stem cells. EMBO Rep. 2020 Jun 4;21(6):e49708 doi:10.15252/embr.201949708. nEpub 2020 Apr 9.PMID: 32270911
Petazzi P, Torres-Ruiz R, Fidanza A, Roca-Ho H, Gutierrez-Agüera F, Castaño J, Rodriguez-Perales S, Díaz de la Guardia R, López-Millán B, Bigas A, Forrester LM, Bueno C, Menéndez P. Robustness of Catalytically Dead Cas9 Activators in Human Pluripotent and Mesenchymal Stem Cells. Mol Ther Nucleic Acids. 2020 Jun 5;20:196-204. doi: 10.1016/j.omtn.2020.02.009. Epub 2020 Feb 27.

Cristina Porcheri, Ohad Golan, Fernando J. Calero-Nieto, Roshana Thambyrajah, Cristina Ruiz-Herguido, Xiaonan Wang, Francesca Catto, Yolanda Guillén, Roshani Sinha, Jessica González, Sarah J. Kinston, Samanta A. Mariani, Antonio Maglitto, Chris S. Vink, Elaine Dzierzak, Pierre Charbord5, Bertie Göttgens, Lluis Espinosa, David Sprinzak, Anna Bigas. Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation (2020) The EMBO J The EMBO J. 39 (8) e104270.

Carlota Colomer, Pol Margalef, Alberto Villanueva, Anna Vert, Irene Pecharroman, Laura Solé, Mónica González-Farré, Josune Alonso, Clara Montagut, Maria Martinez-Iniesta, Joan Bertran, Eva Borràs, Mar Iglesias, Eduard Sabidó, Anna Bigas*, Simon J Boulton*, Lluís Espinosa*.(*corresponding) Ikka kinase regulates DNA damage response and drives chemo-resistance in cancer. Mol. Cell. 2019. doi: 10.1016/j.molcel.2019.05.036.
Fernando Gallardo, Joan Bertran, Erika Lopez, Jessica Gonzalez, Silvia Menendez, Ignacio Sanchez, Luis Colomo, Mar Iglesias, Marta Garrido, Luis Francisco Santamaria, Ferran Torres, Ramon María Pujol, Anna Bigas*, and Lluís Espinosa* (*both last authors) Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma. Leukemia 2018 Feb 22. doi: 10.1038/s41375-018-0066-4.

Erika López-Arribillaga, Verónica Rodilla, Carlota Colomer, Anna Vert, Amy Shelton, Jason H Cheng, Bing Yan, Abel Gonzalez-Perez, Melissa R Junttila, Mar Iglesias, Ferran Torres, Joan Albanell, Alberto Villanueva, Anna Bigas*, Christian W Siebel*, LLuís Espinosa* Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells Nat comm. 2018; 9, 1, 2992 (*corresponding)

Fukushima, Hidefumi; Shimizu, Kouhei; Watahiki, Asami; Hoshikawa, Seira; Kosho, Tomoki; Oba, Daiju; Sakano, Seiji; Arakaki, Makiko; Yamada, Aya; Nagashima, Katsuyuki; Okabe, Koji; Fukumoto, Satoshi; Jimi, Eijiro; Bigas, Anna; Nakayama, Keiichi I.;Nakayama, Keiko; Aoki, Yoko; Wei, Wenyi; Inuzuka, Hiroyuki. NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis. MOLECULAR CELL, 68- 4, 645; 2017

Robles-Valero, J., Lorenzo-Martin F., Menacho-Marquez L,Pisonero I, Abad A, Camos M, Toribio ML, Espinosa L, Bigas A., Bustelo, XR. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia. Cancer Cell, 32, 5, 2017.

Garcia-Alegría E, Lafita-Navarro MC; Aguado R, Garcia-Gutierrez L, Sarnataro K, Ruiz-Herguido C, Martín F, Bigas A, Canelles M, León J. Numb inactivation confers resistance to imatinib in chronic mieloide leucemia Cells. Cancer Lett 2016; 375 (1) 92-99.

β-Catenin is required for T cell leucemia initiation and MYC transcription downstream of Notch1. Christos Gekas, Teresa D’Altri, Rosa Aligué, Jessica González1, Lluis Espinosa, Anna Bigas. Leukemia, 2016 Oct;30(10):2002-2010. (D1, IF: 12,1)

Gama-Norton, Leonor; Ferrando, Eva; Ruiz-Herguido, Cristina; Liu, Zenhy; Guiu, Jordi; Islam, Abul BMMK; Lee, Sung-Uk; Yan, Minhong; Guidos, Cynthia J; Lopez-Bigas, Nuria; Takahiro Maeda, Lluis Espinosa, Raphael Kopan, Anna Bigas.
Notch signal strength controls cell fate in the haemogenic endothelium, Nature Communications, 6,2015 (D1, IF: 11,3)

Fernando Gallardo, Juan Sandoval, Angel Díaz-Lagares, Ricard Garcia, Teresa D'Altri, Jessica González, Victor Alegre, Octavio Servitje, Ana-Belén Crujeiras, Ólafur-Andri Stefánsson, Blanca Espinet, Maria-Inmaculada Hernández, Beatriz Bellosillo, Manel Esteller, Ramon-Maria Pujol, Anna Bigas, Lluis Espinosa.
Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides,Journal of Investigative Dermatology,135,12,3144-3152, 2015 (D1, IF: 6,9)

Helena Serra, Iñigo Chivite, Ana Angulo-Urarte, Adriana Soler, James D Sutherland, Amaia Arruabarrena-Aristorena, Anan Ragab, Radiance Lim, Marcos Malumbres, Marcus Fruttiger, Michael Potente, Manuel Serrano, Àngels Fabra, Francesc Viñals, Oriol Casanovas, Pier Paolo Pandolfi, Anna Bigas, Arkaitz Carracedo, Holger Gerhardt, Mariona Graupera
PTEN mediates Notch-dependent stalk cell arrest in angiogenesis,Nature Communications, 6,2015,Nature Publishing Group (D1, IF: 11,3)

Pol Margalef, Carlota Colomer, Alberto Villanueva, Clara Montagut, Mar Iglesias, Beatriz Bellosillo, Ramón Salazar, María Martínez-Iniesta, Anna Bigas, Lluís Espinosa
BRAF-induced tumorigenesis is IKKα-dependent but NF-κB–independent
Science signaling,8,373,ra38-ra38,2015 (D1, IF: 7,3)

Fernando Gallardo, Andreina Padrón, Ricard Garcia Carbonell, Cristina Rius, Abel González Perez, Montserrat Arumí Uria, Mar Iglesias, Lara Nonell, Beatriz Bellosillo, Sonia Segura, Ramon Maria Pujol, Núria Lopez Bigas, Joan Bertran, Anna Bigas, Lluís Espinosa
Cytoplasmic accumulation of NCoR in malignant melanoma: Consequences of altered gene repression and prognostic significance, Oncotarget. Apr 20;6(11):9284-94. 2015 (Q1, IF: 5,0)

Ayllón, V; Bueno, C; Ramos-Mejía, V; Navarro-Montero, O; Prieto, C; Real, PJ; Romero, T; García-Levin, MJ; Toribio, ML; Bigas, A; Menendez P. The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate, Leukemia. Aug;29(8):1741-53. 2015; doi: 10.1038/leu.2015.74.
(D1, IF: 12,1)

Alberto Martin, Fernando Salvador, Gema Moreno‐Bueno, Alfredo Floristán, Cristina Ruiz‐Herguido, Eva P Cuevas, Saleta Morales, Vanesa Santos, Katalin Csiszar, Pierre Dubus, Jody J Haigh, Anna Bigas, Francisco Portillo, Amparo Cano. Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression, The EMBO journal, Apr 15;34(8):1090-109. 2015
doi: 10.15252/embj.201489975. (D1, IF: 9,6)

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch López-Arribillaga E, Rodilla V, Pellegrinet L, Guiu J, Iglesias M, Roman AC, Gutarra S, González S, Muñoz-Cánoves P, Fernández-Salguero P, Radtke F, Bigas A*, Espinosa L*. (*co-corresponding, equal contribution) Development. 2015 Jan 1;142(1):41-50. (D1, IF: 6,05)
Identification of Cdca7 as a novel Notch transcriptional target involved in Hematopoietic Stem Cells emergente. Jordi Guiu, Dylan J.M. Bergen, Emma De Pater, Abul B.M.M.K. Islam, Verónica Ayllón, Leonor Gama-Norton, Cristina Ruiz-Herguido, Jessica González, Nuria López-Bigas, Pablo Menendez, Elaine Dzierzak, LLuis Espinosa, Anna Bigas. J Exp Med. 2014 Nov 17;211(12):2411-23 (D1, IF: 11,2)

Mucus Enhances Gut Homeostasis and Oral Tolerance by delivering Immunoregulatory signals
Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A. Science, 2013 Oct 25;342(6157):447-53.

Rachael Nimmo, Aldo Ciau-Uitz, Cristina Ruiz-Herguido, Shamit Soneji, Anna Bigas, Roger Patient and Tariq Enver. miR-142-3p controls specification of the hemangioblastic precursors of the blood stem cell lineage. Dev Cell. 2013 Aug 12;26(3):237-49.

María Carmen Mulero; Dolors Ferres Marco; Abul Islam; Pol Margalef; Matteo Pecoraro; Agustí Toll; Nils Drechsel;Cristina Charneco; Shelly Davis; Nicolas Bellora; Fernando Gallardo; Erika López Arribillaga; Elena Asensio;Verónica Rodilla; Jessica González; Mar Iglesias; Vincent Shih; Mar M. Albà; Luciano Di Croce; Alexander Hoffmann; Shigeki Miyamoto; Jordi Villà Freixa; Nuria López Bigas; William M. Keyes; María Dominguez; Anna Bigas*; LLuis Espinosa* (*equal contribution). Chromatin-bound IkBa regulates a subset of Polycomb-target genes in differentiation and cancer. Cancer Cell. 2013 Aug 12;24(2):151-66.

Jordi Guiu, Ritsuko Shimizu, Teresa D’Altri, Stuart T. Fraser, Jun Hatakeyama, Emery H. Bresnick, Ryoichiro Kageyama, Elaine Dzierzak, Masayuki Yamamoto, Lluis Espinosa and Anna Bigas (*equal contribution). Hes repressors are essential regulators of Hematopoietic Stem Cell Development downstream of Notch signaling. J. Exp. Med. 2013 Jan 14;210(1):71-84

Ruiz-Herguido C, Guiu J, D’Altri T, Inglés-Esteve J, Dzierzak E, Espinosa L, Bigas A (*equal contribution). Hematopoietic Stem Cell development requires transient Wnt/b-catenin activity. J. Exp. Med 2012 Jul 30;209(8):1457-68

Espinosa L, Cathelin S, D’Altri T, Trimarchi T, Guiu J, Rodilla V, Inglés-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Rajewsky K, Aifantis I* and Bigas A* (*equal contribution). The Notch/Hes1 pathway sustains NFkB activation through CYLD repression in T cell leukemia. Cancer Cell. Sep 14;18 (3):268-81, 2010.