Publications, Projects and Funding

Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status.
Miralpeix C, Reguera AC, Fosch A, Casas M, Lillo J, Navarro G, Franco R, Casas J, Alexander SPH, Casals N, Rodríguez-Rodríguez R. Br J Pharmacol. 2021 Apr;178(7):1507-1523. doi: 10.1111/bph.15377. Epub 2021 Feb 12. PMID: 33444462

The return of malonyl-CoA to the brain: Cognition and other stories.
Fadó R, Rodríguez-Rodríguez R, Casals N. Prog Lipid Res. 2021 Jan;81:101071. doi: 10.1016/j.plipres.2020.101071. Epub 2020 Nov 10. PMID: 33186641

Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty.
Heras V, Castellano JM, Fernandois D, Velasco I, Rodríguez-Vazquez E, Roa J, Vazquez MJ, Ruiz-Pino F, Rubio M, Pineda R, Torres E, Avendaño MS, Paredes A, Pinilla L, Belsham D, Diéguez C, Gaytán F, Casals N, López M, Tena-Sempere M. Cell Metab. 2020 Dec 1;32(6):951-966.e8. doi: 10.1016/j.cmet.2020.10.001. Epub 2020 Oct 19. PMID: 33080217

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.
Casas M, Fadó R, Domínguez JL, Roig A, Kaku M, Chohnan S, Solé M, Unzeta M, Miñano-Molina AJ, Rodríguez-Álvarez J, Dickson EJ, Casals N. J Cell Biol. 2020 Oct 5;219(10):e201912045. doi: 10.1083/jcb.201912045. PMID: 32931550

An overview of nanomedicines for neuron targeting.
Garcia-Chica J, D Paraiso WK, Tanabe S, Serra D, Herrero L, Casals N, Garcia J, Ariza X, Quader S, Rodriguez-Rodriguez R. Nanomedicine (Lond). 2020 Jul;15(16):1617-1636. doi: 10.2217/nnm-2020-0088. Epub 2020 Jul 3. PMID: 32618490

Drug uptake-based chemoresistance in breast cancer treatment.
Muley H, Fadó R, Rodríguez-Rodríguez R, Casals N. Biochem Pharmacol. 2020 Jul;177:113959. doi: 10.1016/j.bcp.2020.113959. Epub 2020 Apr 7. PMID: 32272110

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth.
Palomo-Guerrero M, Fadó R, Casas M, Pérez-Montero M, Baena M, Helmer PO, Domínguez JL, Roig A, Serra D, Hayen H, Stenmark H, Raiborg C, Casals N. Elife. 2019 Dec 23;8:e51063. doi: 10.7554/eLife.51063. PMID: 31868590

Miralpeix C, Fosch A, Casas J, Baena M, Herrero L, Serra D, Rodríguez-Rodríguez R, Casals N. J. Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice. Lipid Res. 2019 jlr.M092742. First Published on May 28, 2019, doi:10.1194/jlr.M092742

Rodríguez-Rodríguez R, Miralpeix C, Fosch A, Pozo M, Calderón-Domínguez M, Perpinyà X, Vellvehí M, López M, Herrero L, Serra D, Casals N. CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity. Mol Metab. 2019 Jan;19:75-85. doi: 10.1016/j.molmet.2018.10.010.  

Gratacòs-Batlle E, Olivella M, Sánchez-Fernández N, Yefimenko N, Miguez-Cabello F, Fadó R, Casals N, Gasull X, Ambrosio S, Soto D. Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement. Front Mol Neurosci. 2018 Aug 8;11:275. doi: 10.3389/fnmol.2018.00275. 

Roa-Mansergas X, Fadó R, Atari M, Mir JF, Muley H, Serra D, Casals N. CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy. Sci Rep. 2018 May 3;8(1):6997. doi: 10.1038/s41598-018-25485-7. 

Mir JF, Zagmutt S, Lichtenstein MP, García-Villoria J, Weber M, Gracia A, Fabriàs G, Casas J, López M, Casals N, Ribes A, Suñol C, Herrero L, Serra D. Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex. Mol Neurobiol. 2018 Sep;55(9):7216-7228. doi: 10.1007/s12035-018-0921-3.  

Palomo-Guerrero M, Cosgaya JM, Gella A, Casals N, Grijota-Martinez C. Uridine-5'-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells. Neuroscience. 2018 Feb 21;372:255-265. doi: 10.1016/j.neuroscience.2018.01.010.  

Alcalá M, Calderon-Dominguez M, Bustos E, Ramos P, Casals N, Serra D, Viana M, Herrero L. Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice. Sci Rep. 2017 Nov 22;7(1):16082. doi: 10.1038/s41598-017-16463-6. 

Hofmann K, Rodriguez-Rodriguez R, Gaebler A, Casals N, Scheller A, Kuerschner L .Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids. Sci Rep. 2017 Sep 7;7(1):10779. doi: 10.1038/s41598-017-11103-5.

Pozo M, Rodríguez-Rodríguez R, Ramírez S, Seoane-Collazo P, López M, Serra D, Herrero L, Casals N. Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice. Endocrinology (2017).

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab (2017).

Rodríguez-Rodríguez R, Jiménez-Altayó F, Alsina L, Onetti Y, Rinaldi de Alvarenga JF, Claro C, Ogalla E, Casals N, Lamuela-Raventos RM. Mediterranean tomato-based sofrito protects against vascular alterations in obese Zucker rats by preserving NO bioavailability. Mol Nutr Food Res (2017).

Fucho R, Casals N, Serra D, Herrero L. Ceramides and mitochondrial fatty acid oxidation in obesity. FASEB J (2017).

Casals N, Zammit V, Herrero L, Fadó R, Rodríguez-Rodríguez R, Serra D Carnitine palmitoyltransferase 1C: From cognition to cancer. Prog Lipid Res. (2015)

Fadó R, Soto D, Miñano-Molina AJ, Pozo M, Carrasco P, Yefimenko N, Rodríguez-Álvarez J, Casals N. Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus. J Biol Chem. 290(42):25548-60 (2015)

Rinaldi C, Schmidt T, Situ AJ, Johnson JO, Lee PR, Chen KL, Bott LC, Fadó R, Harmison GH, Parodi S, Grunseich C, Renvoisé B, Biesecker LG, De Michele G, Santorelli FM, Filla A, Stevanin G, Dürr A, Brice A, Casals N, Traynor BJ, Blackstone C, Ulmer TS, Fischbeck KH. Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia. JAMA Neurol. (2015)

Malandrino MI, Fucho R, Weber M, Calderon-Dominguez M, Mir JF, Valcarcel L, Escoté X, Gomez-Serrano M, Peral B, Salvadó L, Fernandez-Veledo S, Casals N, Vazquez-Carrera M, Villarroya F, Vendrell JJ, Serra D, Herrero L. Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation. Am J Physiol Endocrinol Metab. (2015)

Contreras C, González-García I, Martínez-Sánchez N, Seoane-Collazo P, Jacas J, Morgan DA, Serra D, Gallego R, Gonzalez F, Casals N, Nogueiras R, Rahmouni K, Diéguez C, López M. Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance. Cell Rep 9(1):366-77 (2014)

Lamarca A, Gella A, Martiañez T, Segura M, Figueiro-Silva J, Grijota-Martinez C, Trullas R, Casals N. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One 9(6):e98998. (2014)

Gao S, McMillan RP, Jacas J, Zhu Q, Li X, Kumar GK, Casals N, Hegardt FG, Robbins PD, Lopaschuk GD, Hulver MW, Butler AA. Regulation of Substrate Oxidation Preferences in Muscle by the Peptide Hormone Adropin. Diabetes 63(10):3242-52 (2014)

Carrasco P, Jacas J, Sahún I, Muley H, Ramírez S, Puisac B, Mezquita P, Pié J, Dierssen M, Casals N. Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity. Behav Brain Res 256:291-7 (2013)

Ramírez S, Martins L, Jacas J, Carrasco P, Pozo M, Clotet J, Serra D, Hegardt FG, Diéguez C, López M, Casals N. Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin. Diabetes 62(7):2329-37. (2013)

Carrasco P, Sahún I, McDonald J, Ramírez S, Jacas J, Gratacós E, Sierra AY,Serra D, Herrero L, Acker-Palmer A, Hegardt FG, Dierssen M, Casals N. Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J Biol Chem 15;287(25):21224-32 (2012)

PCI2018‐092997 Programació Conjunta Internacional. Ministerio de Ciencia, Innovación y Universidades. ¨Drug delivery targeting Brain CPT1: a novel nanomedicine based approach to fight obesity and cancer¨

147.500 € (2019-2021)

Principal Investigator: Rosalía Rodríguez (UIC Barcelona)

SAF2017-82813-C3-3R. “CPT1C en el hipotálamo ventromedial como nueva diana terapéutica en la regulación del balance energético. Mecanismos moleculares implicados.

156.000 € (2018-2020)

Principal Investigators: Núria Casals Farré and Rosalía Rodríguez (UIC Barcelona)

Projecte La Marató de TV3 (87/C/2016) “Carnitine palmitoyltransferase 1- mediated strategies to activate brown fat and reduce food intake to fight against obesity”

125.000 € (2017-2020)

Principal Investigators: Núria Casals Farré (UIC Barcelona) and Dolors Serra (UB)

Projecte La Marató de TV3 (343/U/2014) “Searching new biomarkers and therapeutic targets related to cognitive deficits in early stages of Alzheimer’s disease: role of AKAP79/150, CPT1C and SSAO/VAP-1 in ab-mediated AMPAR dysfunction”

197.000 € (2015-2018)

Principal Investigator: José Rodríguez (UAB)

SAF2014-52223-C2-2-R “Papel de la carnitina pamitoil transferasa 1C como sensor hipotalámico de aciles-CoA y regulador del metabolismo periférico de los lípidos”

Ministerio de Ciencia y Innovación. 125.000 € (2015-2017)

Principal Investigator: Núria Casals Farré (UIC Barcelona)

2014-SGR-465 “Suport a Grups de Recerca (SGR) reconeguts per la Generalitat de Catalunya. Grup Regulació del metabolisme lipídic (METALIP)”

Generalitat de Catalunya (01/01/2014-31/12/2016), 24.000 €

Principal Investigators: Dolores Serra Cucurull (UB) and Núria Casals (UIC Barcelona)

CB06/03/0001 “Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBERobn)”

Instituto de Salud Carlos III (01/01/2007-actualidad). Se ha recibido financiación cada año, en los tres últimos años: 1/01/2012-1/01/2015: 228.200 €

Principal Investigator: Xavier Remesar (UB)