Universitat Internacional de Catalunya
Cellular Therapy and Regenerative Medicine. Bone Marrow, Organ and Tissue Transplant
Other languages of instruction: English, Spanish,
Introduction
Regenerative medicine is the medical discipline that studies the use of stemcells and other types of transplants or for regeneration of damaged tissues impersonation. Regenerative Medicine has made exponential growthin recent years thanks to molecular and cellular biology,and currently represents one of the areas with higher growth expectations and therapeutic usein the near future
Pre-course requirements
Basic knowledge of pathophysiology and molecular and cell biology.
Objectives
Stem Cells and therapeutic applications in regenerative medicine
- Know the natural methods of endogenous regeneration of our fabrics
- Types of stem cells.
- Use of the stem cells in regeneration of bone, cartilage, and adipose tissue
- Stem cells derived from umbilical cord and its therapeutic uses
- Induced pluripotent stem cells (IPSC)
Solid organ transplantation. Results and current problems
- Learning the different types of transplantation with its specific characteristics, prognosis and survival. Knowledge of aspects that affect the long-term (Hepatitis C virus, immunosuppressive therapy itself, etc ...)
Liquid transplant organs.
• Understand the biological basis that condition compatibilidd progenitor
• Know the signs of bone marrow transplantation
• Know the types of TPH and collection systems of bone marrow progenitor cells
• Understand the technology of cell preservation and implantation techniques
Competences/Learning outcomes of the degree programme
- 12 - Understanding the foundations for action, the indications and efficacy of therapeutic interventions, based on available scientific evidence.
- 27 - Recognize role in multidisciplinary teams, assuming leadership when appropriate, for the delivery of health care, such as interventions for health promotion.
- 31 - Understand, critically evaluate and know how to use sources of clinical and biomedical information to obtain, organize, interpret and communicate scientific and health care information.
- 35 - Understand the importance and limitations of scientific thinking in the study, prevention and treatment of disease.
- 37 - Acquire basic training for research.
- CB-5 - To transmit in a clear and unambiguous way to a specialised or non-specialised audience, the results of scientific and technological research projects and innovation from the field of the most advanced innovation, as well as the most important concepts which they are based on.
Learning outcomes of the subject
Stem Cells and therapeutic applications in regenerative medicine
- Students will learn the different types of adult stem cells and tissues where they are, potential, biological niche, etc.
- Students will learn about the uses and disadvantages of mesenchymal stem cells in the regeneration of hard tissue such as bone or cartilage. Also known most commonly used biomaterials to give the necessary three-dimensional structure.
- Students will learn the operation of a bank of umbilical cord and their therapeutic applications
- Students will learn the process of obtaining iPSC cells as well as their advantages and disadvantages compared to other types of stem cells.
Solid organ transplantation. Results and current problems
- The student will know the indications and methodology used in transplants more common solid organs: liver, lung, heart and kidney.
- Students will be able to identify and prevent those common problems and can be relatively easily resolved if they are diagnosed early (bacterial and viral infection, rejection, etc ...)
- Students will be able to recognize the current site of transplantation in treatment of various diseases and the problems that are still unresolved (donation, organ quality, metabolic syndrome, etc..)
Liquid transplant organs.
- Students will learn the basics of the HLA system and its role in the rejection of TPH
- Students will learn the various sources of obtaining parents and mobilization methods to obtain them.
- The student will know the indications and methodology used in transplants of hematopoietic progenitors.
- Students will be able to identify and prevent those common problems and can be relatively easily resolved if they are diagnosed early (bacterial and viral infection, rejection, etc ...)
- Students will be able to know the basic principles of management of the transplanted patient, focusing on all aspects loas support, prevention and treatment of the most common acute complications.
- Students will learn about the different stages of TPH
- The student will know the basic principles of cryobiology that allow the preservation and storage of stem cells
Syllabus
Stem Cells and therapeutic applications in regenerative medicine
- Natural regeneration of tissues
- Types of stem cells. Current and future uses
- Mesenchymal stem cells and their use in the regeneration of bone, cartilage, and adipose tissue
- Tissue bank of umbilical cord. Therapeutic uses.
- Development of the IPSC cells. Advantages and disadvantages compared to other stem cells.
Solid organ transplantation. Results and current problems
- The problem of the Grant. organizational systems
- The heart and lung transplant
- Renal and Liver Transplantation
- From living donor transplantation. Renal and Hepatic
- Transplantation from heart-beating donor
- Immunosuppression Guidelines. induction
- Side Effects of Immunosuppression
- The quality of life beyond 10 years
Liquid transplant organs.
- Fundamentals, Types and indications of stem cell transplantation (HSCT)
- Sources of obtaining parental
- TPH concept unit
- Accreditation of centers
- Cost Analysis
- Indications and results
- Assessment of patient
- Selection of the donor and donor assessment. Concepts of unrelated donor
- Conditioning treatments
- Getting parents: bone marrow, peripheral blood.
- Mobilisation of peripheral blood progenitors
- Product obtained: handling, processing control, purging, removal of inoculum linfocits T, implementation and chimerism
- Patient management: central venous catheter, transfusion support, nutritional support, prevention of disease Graft versus host disease (GVHD) prophylaxis infections
- Complications: implant failure, action to take in the febrile neutropenic patient infections: bacterial, fungal, viral,
- Hepatic veno-occlusive disease
- Disease GVH
- Late Complications
- Second neoplasms
- Relapse post HSCT
Bibliography and resources
Manual de trasplante hemopoyético. Tercera edición. Enric Carreras, Salut Brunet, JJ Ortega, Jorge Sierra, Alvaro Urbano. Editorila Antares 2004