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Our teaching and research team
WRIGHT, Roni Helene Grace
Professor
Col.laborador
DEPARTMENT OF BASIC SCIENCIES
Department of
Basic Areas
From cell metabolism to metabolic diseases (METADIS)
Contact
Academic training
-
Molecular Biology
- University of Glasgow
Doctora Phd Molecular Biology and Cancer - UNIVERSITY OF GLASGOW
Llicenciada Bsc (honors) Biochemistry and Immunology - UNIVERSITY OF STRATHCLYDE
Publications
-
Cellular and molecular life sciences, A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane
Name: Font Mateu, J.; Sanllehí, P.; Sot, J.; Abad, B.; Mateos, N.; Torreno, J.; Ferrari, R.; Wright, R.; Garcia, M.; Joglar, J.; Goñi, F.; Beato, M. Role: Autor Publishing date: 2024Vol.: 81 No.: 1DOI: https://dx.doi.org/10.1007/s00018-024-05116-3 ISSN or title: 1420-682X -
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?
Name: Manousakis, E.; Martinez, C.; Guimerà, M.; Wright, R. Role: Autor Publishing date: 2023Vol.: 24 No.: 24DOI: https://dx.doi.org/10.3390/ijms242417488 ISSN or title: 1661-6596 -
Cancer research, Combinatorial treatment with PARP and MAPK inhibitors overcomes phenotype switch-driven drug resistance in advanced melanoma
Name: Ferretti, L.; Böhi, F.; Leslie, D.; Cheng, P.; Ferrari, E.; Baumgaertner, P.; Alvarado, A.; Sella, F.; Cereghetti, A.; Turko, P.; Wright, R.; De Bock, K.; Speiser, D.; Ferrari, R.; Levesque, M.; Hottiger, M. Role: Autor Publishing date: 2023Start page: 3974 End page: 3988 Vol.: 83 No.: 23DOI: https://dx.doi.org/10.1158/0008-5472.CAN-23-0485 ISSN or title: 0008-5472 -
Cell Reports, The ADP-ribose hydrolase NUDT5 is important for DNA repair
Name: Wright, R. Role: Autor Publishing date: 2022Vol.: 41 No.: 12DOI: https://dx.doi.org/10.1016/j.celrep.2022.111866 ISSN or title: 2211-1247 -
Frontiers in Endocrinology, Global signalling network analysis of luminal T47D breast cancer cells in response to progesterone
Name: Wright, R. Role: Autor Publishing date: 2022Start page: 1 End page: 19 Vol.: 13 No.: 19DOI: https://dx.doi.org/https://doi.org/10.3389/fendo.2022.888802 ISSN or title: 1664-2392 -
Iscience, MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast trans-differentiation
Name: Bisceglie, L.; Hopp, A.-K.; Gunasekera, K.; Wright, R.; Le Dily, F.; Vidal, E.; Dall’Agnese, A.; Caputo, L.; Nicoletti, C.; Puri, P.L.; Beato, M.; Hottiger, M. Role: Autor Publishing date: 2021Vol.: 24 No.: 5DOI: https://dx.doi.org/10.1016/j.isci.2021.102432 ISSN or title: 2589-0042 -
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Role of the nudt enzymes in breast cancer
Name: Wright, R.; Beato, M. Role: Autor Publishing date: 2021Start page: 1 End page: 14 Vol.: 22 No.: 5DOI: https://dx.doi.org/10.3390/ijms22052267 ISSN or title: 1661-6596 -
Journal of molecular endocrinology, 90 YEARS OF PROGESTERONE: Molecular mechanisms of progesterone receptor action on the breast cancer genome
Name: Beato, M.; Wright, R.; Le Dily, F. Role: Autor Publishing date: 2020Start page: T65 End page: T79 Vol.: 65 No.: 1DOI: https://dx.doi.org/10.1530/JME-19-0266 ISSN or title: 0952-5041 -
CANCERS, Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5
Name: Pickup, K.E.; Pardow, F.; Carbonell, J.; Lioutas, A.; Villanueva, J.; Wright, R.; Beato, M. Role: Autor Publishing date: 2019Vol.: 11 No.: 9DOI: https://dx.doi.org/10.3390/cancers11091337 ISSN or title: 2072-6694 -
Trends in biochemical sciences, ATP, Mg2+, Nuclear Phase Separation, and Genome Accessibility
Name: Wright, R.; Le Dily, F.; Beato, M. Role: Autor Publishing date: 2019Start page: 565 End page: 574 Vol.: 44 No.: 7DOI: https://dx.doi.org/10.1016/j.tibs.2019.03.001 ISSN or title: 0968-0004 -
Molecular cell, Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription
Name: Sharma, P.; Lioutas, A.; Fernández-Fuentes, N.; Quílez, J.; Carbonell, J.; Wright, R.; Di Vona, C.; Le Dily, F.; Schueller, R.; Eick, D.; Oliva, B.; Beato, M. Role: Autor Publishing date: 2019Vol.: 73 No.: 1DOI: https://dx.doi.org/10.1016/j.molcel.2018.10.016 ISSN or title: 1097-2765 -
Genome research, Hormone-control regions mediate steroid receptor–dependent genome organization
Name: Le Dily, F.; Vidal, E.; Cuartero, Y.; Quílez, J.; Nacht, A.; Vicent, G.; Carbonell, J.; Sharma, P.; Villanueva, J.; Ferrari, R.; de Llobet, L.; Verde, G.; Wright, R.; Beato, M. Role: Autor Publishing date: 2019Start page: 29 End page: 39 Vol.: 29 No.: 1DOI: https://dx.doi.org/10.1101/gr.243824.118 ISSN or title: 1088-9051 -
CANCERS, Unliganded Progesterone Receptor Governs Estrogen Receptor Gene Expression by Regulating DNA Methylation in Breast Cancer Cells
Name: Verde, G.; de Llobet, L.; Wright, R.; Quílez, J.; Peiró, S.; Le Dily, F.; Beato, M. Role: Autor Publishing date: 2018Vol.: 10 No.: 10DOI: https://dx.doi.org/10.3390/cancers10100371 ISSN or title: 2072-6694 -
Nature communications, Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Name: Page, B.D.G.; Valerie, N.C.K.; Wright, R.; Wallner, O.; Isaksson, R.; Carter, M.; Rudd, S.G.; Jemth, A.S.; Almlof, I.; Font-Mateu, J.; Llona-Minguez, S.; Baranczewski, P.; Jeppsson, F.; Homan, E.; Almqvist, H.; Axelsson, H.; Regmi, S.; Gustavsson, A.; Lundback, T.; Scobie, M.; Stromberg, K.; Stenmark, P.; Beato, M.; Helleday, T. Role: Autor Publishing date: 2018Vol.: 9DOI: https://dx.doi.org/10.1038/s41467-017-02293-7 ISSN or title: 2041-1723 -
Nucleus-Austin, Insight into the machinery that oils chromatin dynamics
Name: Wright, R.; Fernández-Fuentes, N.; Oliva, B.; Beato, M. Role: Autor Publishing date: 2016Start page: 532 End page: 539 Vol.: 7 No.: 6DOI: https://dx.doi.org/10.1080/19491034.2016.1255392 ISSN or title: 1949-1034 -
Embo journal, Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters
Name: Nacht, A. S.; Pohl, A.; Zaurin, R.; Soronellas, D.; Quílez, J.; Sharma, P.; Wright, R.; Beato, M.; Vicent, G. Role: Autor Publishing date: 2016Start page: 1822 End page: 1843 Vol.: 35 No.: 16ISSN or title: 0261-4189 -
Science, ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
Name: Wright, R.; Lioutas, A.; Le Dily, F.; Soronellas, D.; Pohl, A.; Bonet, J.; Nacht, A. S.; Samino, S.; Font-Mateu, J.; Vicent, Guillermo P.; Wierer, M.; Trabado, M.A.; Schelhorn, C.; Carolis, C.; Macias, M.J.; Yanes, O.; Oliva, B.; Beato, M. Role: Autor Publishing date: 2016Start page: 1221 End page: 1225 Vol.: 352 No.: 6290DOI: https://dx.doi.org/10.1126/science.aad9335 ISSN or title: 0036-8075 -
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, Linker histones in hormonal gene regulation
Name: Vicent, G.; Wright, R.; Beato, M. Role: Autor Publishing date: 2016Start page: 520 End page: 525 Vol.: 1859 No.: 3DOI: https://dx.doi.org/10.1016/j.bbagrm.2015.10.016 ISSN or title: 1874-9399 -
Cell research, DNA damage and gene transcription: accident or necessity?
Name: Beato, M.; Wright, R.; Vicent, Guillermo P. Role: Autor Publishing date: 2015Start page: 769 End page: 770 Vol.: 25 No.: 7DOI: https://dx.doi.org/10.1038/cr.2015.71 ISSN or title: 1001-0602 -
Genes and development, Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation
Name: Le Dily, F.; Bau, D.; Pohl, A.; Vicent, G.; Serra, F.; Soronellas, D.; Castellano, G.; Wright, R.; Ballare, C.; Filion, G.; Marti-Renom, M.; Beato, M. Role: Autor Publishing date: 2014Start page: 2151 End page: 2162 Vol.: 28 No.: 19DOI: https://dx.doi.org/10.1101/gad.241422.114 ISSN or title: 0890-9369 -
Cell cycle, PARty promoters Hormone-dependent gene regulation requires CDK2 activation of PARP1
Name: Wright, R.; Beato, M. Role: Autor Publishing date: 2012Start page: 4291 End page: 4293 Vol.: 11 No.: 23DOI: https://dx.doi.org/10.4161/cc.22531 ISSN or title: 1538-4101 -
Genes and development, CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells
Name: Wright, R.; Castellano, G.; Bonet, J.; Le Dily, F.; Font Mateu, J.; Ballare, C.; Nacht, S.; Soronellas, D.; Oliva, B.; Beato, M. Role: Autor Publishing date: 2012Start page: 1972 End page: 1983 Vol.: 26 No.: 17DOI: https://dx.doi.org/10.1101/gad.193193.112 ISSN or title: 0890-9369
Publications
-
Progesterone Signaling to Chromatin in Breast Cancer Cells. Two Initial Cycles of Remodeling
Subjects taught
Course 2024-2025 - Period: 01/09/2024 - 31/08/2025
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Human Biology 1
- - Human Biology 2
Course 2023-2024 - Period: 01/09/2023 - 31/08/2024
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Human Biology 1
- - Human Biology 2
Course 2022-2023 - Period: 01/09/2022 - 31/08/2023
-
Bachelor’s Degree
Bachelor's Degree in Biomedical Sciences- - Cancer Biology
- - Microbiology and Immunology
- - Human Biology 2
- - Human Biology 1
Course 2021-2022 - Period: 01/09/2021 - 31/08/2022
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Human Biology 2
- - Microbiology and Immunology
Course 2020-2021 - Period: 01/09/2020 - 31/08/2021
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Microbiology and Immunology
Course 2019-2020 - Period: 01/09/2019 - 31/08/2020
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Microbiology and Immunology
Course 2018-2019 - Period: 01/09/2018 - 31/08/2019
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Microbiology and Immunology
-
Molecular Biology
- University of Glasgow
Doctora Phd Molecular Biology and Cancer - UNIVERSITY OF GLASGOW
Llicenciada Bsc (honors) Biochemistry and Immunology - UNIVERSITY OF STRATHCLYDE
-
Cellular and molecular life sciences, A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane
Name: Font Mateu, J.; Sanllehí, P.; Sot, J.; Abad, B.; Mateos, N.; Torreno, J.; Ferrari, R.; Wright, R.; Garcia, M.; Joglar, J.; Goñi, F.; Beato, M. Role: Autor Publishing date: 2024Vol.: 81 No.: 1DOI: https://dx.doi.org/10.1007/s00018-024-05116-3 ISSN or title: 1420-682X -
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?
Name: Manousakis, E.; Martinez, C.; Guimerà, M.; Wright, R. Role: Autor Publishing date: 2023Vol.: 24 No.: 24DOI: https://dx.doi.org/10.3390/ijms242417488 ISSN or title: 1661-6596 -
Cancer research, Combinatorial treatment with PARP and MAPK inhibitors overcomes phenotype switch-driven drug resistance in advanced melanoma
Name: Ferretti, L.; Böhi, F.; Leslie, D.; Cheng, P.; Ferrari, E.; Baumgaertner, P.; Alvarado, A.; Sella, F.; Cereghetti, A.; Turko, P.; Wright, R.; De Bock, K.; Speiser, D.; Ferrari, R.; Levesque, M.; Hottiger, M. Role: Autor Publishing date: 2023Start page: 3974 End page: 3988 Vol.: 83 No.: 23DOI: https://dx.doi.org/10.1158/0008-5472.CAN-23-0485 ISSN or title: 0008-5472 -
Cell Reports, The ADP-ribose hydrolase NUDT5 is important for DNA repair
Name: Wright, R. Role: Autor Publishing date: 2022Vol.: 41 No.: 12DOI: https://dx.doi.org/10.1016/j.celrep.2022.111866 ISSN or title: 2211-1247 -
Frontiers in Endocrinology, Global signalling network analysis of luminal T47D breast cancer cells in response to progesterone
Name: Wright, R. Role: Autor Publishing date: 2022Start page: 1 End page: 19 Vol.: 13 No.: 19DOI: https://dx.doi.org/https://doi.org/10.3389/fendo.2022.888802 ISSN or title: 1664-2392 -
Iscience, MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast trans-differentiation
Name: Bisceglie, L.; Hopp, A.-K.; Gunasekera, K.; Wright, R.; Le Dily, F.; Vidal, E.; Dall’Agnese, A.; Caputo, L.; Nicoletti, C.; Puri, P.L.; Beato, M.; Hottiger, M. Role: Autor Publishing date: 2021Vol.: 24 No.: 5DOI: https://dx.doi.org/10.1016/j.isci.2021.102432 ISSN or title: 2589-0042 -
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Role of the nudt enzymes in breast cancer
Name: Wright, R.; Beato, M. Role: Autor Publishing date: 2021Start page: 1 End page: 14 Vol.: 22 No.: 5DOI: https://dx.doi.org/10.3390/ijms22052267 ISSN or title: 1661-6596 -
Journal of molecular endocrinology, 90 YEARS OF PROGESTERONE: Molecular mechanisms of progesterone receptor action on the breast cancer genome
Name: Beato, M.; Wright, R.; Le Dily, F. Role: Autor Publishing date: 2020Start page: T65 End page: T79 Vol.: 65 No.: 1DOI: https://dx.doi.org/10.1530/JME-19-0266 ISSN or title: 0952-5041 -
CANCERS, Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5
Name: Pickup, K.E.; Pardow, F.; Carbonell, J.; Lioutas, A.; Villanueva, J.; Wright, R.; Beato, M. Role: Autor Publishing date: 2019Vol.: 11 No.: 9DOI: https://dx.doi.org/10.3390/cancers11091337 ISSN or title: 2072-6694 -
Trends in biochemical sciences, ATP, Mg2+, Nuclear Phase Separation, and Genome Accessibility
Name: Wright, R.; Le Dily, F.; Beato, M. Role: Autor Publishing date: 2019Start page: 565 End page: 574 Vol.: 44 No.: 7DOI: https://dx.doi.org/10.1016/j.tibs.2019.03.001 ISSN or title: 0968-0004 -
Molecular cell, Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription
Name: Sharma, P.; Lioutas, A.; Fernández-Fuentes, N.; Quílez, J.; Carbonell, J.; Wright, R.; Di Vona, C.; Le Dily, F.; Schueller, R.; Eick, D.; Oliva, B.; Beato, M. Role: Autor Publishing date: 2019Vol.: 73 No.: 1DOI: https://dx.doi.org/10.1016/j.molcel.2018.10.016 ISSN or title: 1097-2765 -
Genome research, Hormone-control regions mediate steroid receptor–dependent genome organization
Name: Le Dily, F.; Vidal, E.; Cuartero, Y.; Quílez, J.; Nacht, A.; Vicent, G.; Carbonell, J.; Sharma, P.; Villanueva, J.; Ferrari, R.; de Llobet, L.; Verde, G.; Wright, R.; Beato, M. Role: Autor Publishing date: 2019Start page: 29 End page: 39 Vol.: 29 No.: 1DOI: https://dx.doi.org/10.1101/gr.243824.118 ISSN or title: 1088-9051 -
CANCERS, Unliganded Progesterone Receptor Governs Estrogen Receptor Gene Expression by Regulating DNA Methylation in Breast Cancer Cells
Name: Verde, G.; de Llobet, L.; Wright, R.; Quílez, J.; Peiró, S.; Le Dily, F.; Beato, M. Role: Autor Publishing date: 2018Vol.: 10 No.: 10DOI: https://dx.doi.org/10.3390/cancers10100371 ISSN or title: 2072-6694 -
Nature communications, Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Name: Page, B.D.G.; Valerie, N.C.K.; Wright, R.; Wallner, O.; Isaksson, R.; Carter, M.; Rudd, S.G.; Jemth, A.S.; Almlof, I.; Font-Mateu, J.; Llona-Minguez, S.; Baranczewski, P.; Jeppsson, F.; Homan, E.; Almqvist, H.; Axelsson, H.; Regmi, S.; Gustavsson, A.; Lundback, T.; Scobie, M.; Stromberg, K.; Stenmark, P.; Beato, M.; Helleday, T. Role: Autor Publishing date: 2018Vol.: 9DOI: https://dx.doi.org/10.1038/s41467-017-02293-7 ISSN or title: 2041-1723 -
Nucleus-Austin, Insight into the machinery that oils chromatin dynamics
Name: Wright, R.; Fernández-Fuentes, N.; Oliva, B.; Beato, M. Role: Autor Publishing date: 2016Start page: 532 End page: 539 Vol.: 7 No.: 6DOI: https://dx.doi.org/10.1080/19491034.2016.1255392 ISSN or title: 1949-1034 -
Embo journal, Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters
Name: Nacht, A. S.; Pohl, A.; Zaurin, R.; Soronellas, D.; Quílez, J.; Sharma, P.; Wright, R.; Beato, M.; Vicent, G. Role: Autor Publishing date: 2016Start page: 1822 End page: 1843 Vol.: 35 No.: 16ISSN or title: 0261-4189 -
Science, ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling
Name: Wright, R.; Lioutas, A.; Le Dily, F.; Soronellas, D.; Pohl, A.; Bonet, J.; Nacht, A. S.; Samino, S.; Font-Mateu, J.; Vicent, Guillermo P.; Wierer, M.; Trabado, M.A.; Schelhorn, C.; Carolis, C.; Macias, M.J.; Yanes, O.; Oliva, B.; Beato, M. Role: Autor Publishing date: 2016Start page: 1221 End page: 1225 Vol.: 352 No.: 6290DOI: https://dx.doi.org/10.1126/science.aad9335 ISSN or title: 0036-8075 -
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, Linker histones in hormonal gene regulation
Name: Vicent, G.; Wright, R.; Beato, M. Role: Autor Publishing date: 2016Start page: 520 End page: 525 Vol.: 1859 No.: 3DOI: https://dx.doi.org/10.1016/j.bbagrm.2015.10.016 ISSN or title: 1874-9399 -
Cell research, DNA damage and gene transcription: accident or necessity?
Name: Beato, M.; Wright, R.; Vicent, Guillermo P. Role: Autor Publishing date: 2015Start page: 769 End page: 770 Vol.: 25 No.: 7DOI: https://dx.doi.org/10.1038/cr.2015.71 ISSN or title: 1001-0602 -
Genes and development, Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation
Name: Le Dily, F.; Bau, D.; Pohl, A.; Vicent, G.; Serra, F.; Soronellas, D.; Castellano, G.; Wright, R.; Ballare, C.; Filion, G.; Marti-Renom, M.; Beato, M. Role: Autor Publishing date: 2014Start page: 2151 End page: 2162 Vol.: 28 No.: 19DOI: https://dx.doi.org/10.1101/gad.241422.114 ISSN or title: 0890-9369 -
Cell cycle, PARty promoters Hormone-dependent gene regulation requires CDK2 activation of PARP1
Name: Wright, R.; Beato, M. Role: Autor Publishing date: 2012Start page: 4291 End page: 4293 Vol.: 11 No.: 23DOI: https://dx.doi.org/10.4161/cc.22531 ISSN or title: 1538-4101 -
Genes and development, CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells
Name: Wright, R.; Castellano, G.; Bonet, J.; Le Dily, F.; Font Mateu, J.; Ballare, C.; Nacht, S.; Soronellas, D.; Oliva, B.; Beato, M. Role: Autor Publishing date: 2012Start page: 1972 End page: 1983 Vol.: 26 No.: 17DOI: https://dx.doi.org/10.1101/gad.193193.112 ISSN or title: 0890-9369
-
Progesterone Signaling to Chromatin in Breast Cancer Cells. Two Initial Cycles of Remodeling
Course 2024-2025 - Period: 01/09/2024 - 31/08/2025
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Human Biology 1
- - Human Biology 2
Course 2023-2024 - Period: 01/09/2023 - 31/08/2024
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Human Biology 1
- - Human Biology 2
Course 2022-2023 - Period: 01/09/2022 - 31/08/2023
-
Bachelor’s Degree
Bachelor's Degree in Biomedical Sciences- - Cancer Biology
- - Microbiology and Immunology
- - Human Biology 2
- - Human Biology 1
Course 2021-2022 - Period: 01/09/2021 - 31/08/2022
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Human Biology 2
- - Microbiology and Immunology
Course 2020-2021 - Period: 01/09/2020 - 31/08/2021
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Microbiology and Immunology
Course 2019-2020 - Period: 01/09/2019 - 31/08/2020
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Microbiology and Immunology
Course 2018-2019 - Period: 01/09/2018 - 31/08/2019
-
Bachelor’s Degree
Bachelor's Degree in Dentistry- - Microbiology and Immunology