Ext. 5223, 4240
Departamento de Ciencias Básicas
Regulació del metabolisme lipídic en l'obesitat i la diabetis (METALIP)



Perfil del profesor

Professor Catedràtic

Ciencias Básicas, DEPARTAMENTO DE CIENCIAS BÁSICAS. Universitat Internacional de Catalunya

Formación académica
  • Doctora en Farmàcia Universitat de Barcelona
  • Master en Economia de la Salut i Gestió Sanitària Universitat de Barcelona/Universitat Pompeu Fabra
  • Farmàcia Universitat de Barcelona


  • Fadó, R.; Molins, A.; Rojas, R.; Casals, N, (2022), "Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors", Nutrients, vol. 14, ISSN: 2072-6643.
  • Miralpeix, C.; Reguera, A.; Fosch, A.; Zagmutt, S.; Casals, N; Cota, D.; Rodriguez-Rodriguez, R., (2021), "Hypothalamic endocannabinoids in obesity: an old story with new challenges", Cellular and molecular life sciences, vol. 78, No. 23, pp. 7469-7490, ISSN: 1420-682X.
  • Paraiso, W.; Garcia, J.; Ariza, J.; Zagmutt, S.; Fukushima, S.; Garcia, J.; Mochida, Y.; Serra, D.; Herrero, L.; Kinoh, H.; Casals, N; Kataoka, K.; Rodriguez-Rodriguez, R.; Quader, S., (2021), "Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells", Biomaterials science, vol. 9, No. 21, pp. 7076-7091, ISSN: 2047-4830.
  • Lillo, J.; Lillo, A.; Zafra, D.A.; Miralpeix, C.; Rivas-Santisteban, R.; Casals, N; Navarro, G.; Franco, R., (2021), "Identification of the ghrelin and cannabinoid cb2 receptor heteromer functionality and marked upregulation in striatal neurons from offspring of mice under a high-fat diet", International Journal of Molecular Sciences, vol. 22, No. 16, ISSN: 1422-0067.
  • Fosch, A.; Zagmutt, S.; Casals, N; Rodriguez-Rodriguez, R., (2021), "New insights of sf1 neurons in hypothalamic regulation of obesity and diabetes", International Journal of Molecular Sciences, vol. 22, No. 12, ISSN: 1422-0067.
  • Miralpeix, C.; Reguera, A.; Fosch, A.; Casas, M.; Lillo, J.; Navarro, G.; Franco, R.; Casas, J.; Alexander, S.P.H.; Casals, N; Rodriguez-Rodriguez, R., (2021), "Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status", British journal of pharmacology, ISSN: 0007-1188.
  • Fadó, R.; Rodriguez-Rodriguez, R.; Casals, N, (2021), "The return of malonyl-CoA to the brain: Cognition and other stories", Progress in lipid research, vol. 81, ISSN: 0163-7827.
  • Heras, V.; Castellano, J.M.; Fernandois, D.; Velasco, I.; Rodríguez-Vázquez, E.; Roa, J.; Vazquez, M.J.; Ruiz-Pino, F.; Rubio, M.; Pineda, R.; Torres, E.; Avendaño, M.S.; Paredes, A.H.; Pinilla, L.; Belsham, D.D.; Diéguez, C.; Gaytán, F.; Casals, N; López, M.; Tena-Sempere, M., (2020), "Central ceramide signaling mediates obesity-induced precocious puberty", Cell metabolism, vol. 32, No. 6, ISSN: 1550-4131.
  • Casas, M.; Fadó, R.; Domínguez, J.L.; Roig, A.; Kaku, M.; Chohnan, S.; Solé, M.; Unzeta, M.; Miñano-Molina, A.; Rodríguez, J.; Dickson, E.; Casals, N, (2020), "Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking", Journal of cell biology, vol. 219, No. 10, ISSN: 0021-9525.
  • Weber, M.; Mera, P.; Casas, J.; Salvador, J.; Rodriguez, A.; Alonso, S.; Sebastián, D.; Soler-Vázquez, M.C.; Montironi, C.; Recalde, S.; Fucho, R.; Calderón Domínguez, M.; Mir, J.; Bartrons, R.; Escolá-Gil, J.; Sánchez-Infantes, D.; Zorzano, A.; Llorente-Cortés, V.; Casals, N; Valentí, V.; Frúhbeck, G.; Herrero, L.; Serra, D., (2020), "Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD", Faseb journal, vol. 34, No. 9, pp. 11816-11837, ISSN: 0892-6638.
  • Garcia-Chica, J.; Paraiso, W.; Tanabe, S.; Serra, D.; Herrero, L.; Casals, N; Garcia, J.; Ariza, X.; Quader, S.; Rodriguez-Rodriguez, R., (2020), "An overview of nanomedicines for neuron targeting", Nanomedicine, vol. 15, No. 16, pp. 1617-1636, ISSN: 1743-5889.
  • Muley, H.; Fadó, R.; Rodriguez-Rodriguez, R.; Casals, N, (2020), "Drug uptake-based chemoresistance in breast cancer treatment", Biochemica pharmacology, vol. 177, ISSN: 0006-2952.
  • Cheng, W.; Siedlecki-Wullich, D.; Català-Solsona, J.; Fàbregas, C.; Fadó, R.; Casals, N; Solé, M.; Unzeta, M.; Saura, C.; Rodríguez, J.; Miñano-Molina, A., (2020), "Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD", eNeuro, vol. 7, No. 2, ISSN: 2373-2822.
  • Palomo-Guerrero, M.; Fadó, R.; Casas, M.; Pérez-Montero, M.; Baena, M.; Helmer, PO.; Domínguez, JL.; Roig, A.; Serra, D.; Hayen, H.; Stenmark, H.; Raiborg, C.; Casals, N, (2019), "Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth", eLife, vol. 8, ISSN: 2050-084X.
  • Solé, M.; Esteban, M.; Taltavull, B.; Fàbregas, C.; Fadó, R.; Casals, N; Rodríguez, J.; Miñano-Molina, A.; Unzeta, M., (2019), "Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition", Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1865, No. 9, pp. 2189-2202, ISSN: 1879-260X 09254439.
  • Miralpeix, C.; Fosch, A.; Casas, J.; Baena, M.; Herrero, L.; Serra, D.; Rodriguez-Rodriguez, R.; Casals, N, (2019), "Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice", Journal of lipid research, vol. 60, No. 7, pp. 1260-1269, ISSN: 0022-2275.
  • Rodriguez-Rodriguez, R.; Miralpeix, C.; Fosch, A.; Pozo Ariza, M; Calderón Domínguez, M.; Perpinyà, X.; Vellvehi, M.; López, M.; Herrero, L.; Serra, D.; Casals, N, (2019), "CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity", Molecular Metabolism, vol. 19, pp. 75-85, ISSN: 2212-8778.
  • Gratacós, E.; Olivella, M.; Sánchez, N.; Yefimenko, N.; Miguez, F.; Fadó, R.; Casals, N; Gasull, X.; Ambrosio, S.; Soto, D., (2018), "Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement", Frontiers in Molecular Neuroscience, vol. 11, No. 275, ISSN: 1662-5099.
  • Roa, X.; Al-Atari Abou-Asi, M; Fadó, R.; Mir, J.; Muley, H.; Serra, D.; Casals, N, (2018), "CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy", Scientific Reports, vol. 8, ISSN: 2045-2322.
  • Mir, J.; Zagmutt, S.; Lichtenstein, M.; Casals, N; Herrero, L.; Serra, D., (2018), "Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex", Molecular neurobiology, vol. 55, pp. 7216-7228, ISSN: 0893-7648.
  • Palomo-Guerrero, M.; Cosgaya, J.; Gella, A.; Casals, N; Grijota-Martinez,C., (2018), "Uridine-5'-triphosphate partially partially blocks differentiation signals and favors a more repair state in cultured rat Schwann cells", Neuroscience, ISSN: 0306-4522.
  • Alcalá, M.; Calderón Domínguez, M.; Bustos, E.; Ramos, P.; Casals, N; Serra, D.; Viana, M.; Herrero, L., (2017), "Increased infammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice", Scientific Reports, vol. 7, ISSN: 2045-2322.
  • Hofmann, K.; Rodriguez-Rodriguez, R.; Gaebler, A.; Casals, N; Scheller, A.; Kuerschner, L., (2017), "Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids", Scientific Reports, vol. 7, ISSN: 2045-2322.
  • Rodriguez-Rodriguez, R.; Jimenez-Altayo, F.; Alsina, L.; Onetti, Y.; Rinaldi de Alvarenga, J.; Claro, C.; Ogalla, E.; Casals, N; Lamuela Raventos, R., (2017), "Mediterranean tomato-based sofrito protects against vascular alterations in obese Zucker rats by preserving NO bioavailability", Molecular nutrition and food research, vol. 61, No. 9, ISSN: 1613-4125.
  • Martínez Sánchez, N.; Seoane Collazo, P.; Contreras, C.; Valera, L.; Villarroya, J.; Rial Pensado, E.; Buque, X.; Aurrekoetxea, I.; Delgado, M.; Martinez Vazquez, J.; Gonzalez, R.; Roa, J.; whittle, A.; Gomez, B.; Velagapudi, V.; Loraine, Y.; Morgan, D.; Voshol, P.; Martinez de morterin, P.; Lopez, T.; Linares Pose, L.; Gonzalez, F.; Chatterjee, K.; Sobrino, T.; Medina, G.; Davis, R.; Casals, N; Oresic, M.; Coll, A.; Vidal Puig, A.; Mittag, J.; Sempere, M.; Malagon, M.; Dieguez, C.; Martinez Chantar, M.; Espichueta, P.; Rahmouni, K.; Nogueiras, R.; Sabio, G.; Villarroya, F.; López, M., (2017), "Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance", Cell metabolism, vol. 26, No. 1, pp. 212-229, ISSN: 1550-4131.
  • Pozo Ariza, M; Rodriguez-Rodriguez, R.; Ramírez, S.; Seoane Collazo, P.; López, M.; Serra, D.; Herrero, L.; Casals, N, (2017), "Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice", Endocrinology, ISSN: 1945-7170.
  • Fucho, R.; Casals, N; Serra, D.; Herrero, L., (2017), "Ceramides and mitochondrial fatty acid oxidation in obesity", Faseb journal, vol. 31, No. 4, pp. 1263-1272, ISSN: 0892-6638.
  • Contreras, C.; Gonzalez, Mj.; Seoane-Collazo, P.; Casals, N; Diéguez, C.; Nogueiras, R.; López, M., (2017), "Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity", Diabetes, vol. 66, No. 1, ISSN: 0012-1797.
  • Palomo-Guerrero, M.; Fadó, R.; Moreno, B.; Rodríguez-Rodríguez, R.; Casals, N, (2016), "Abstracts of the XXXVIII Congress of the Spanish Society of Physiological Sciences (SECF), 13-16 September 2016, Zaragoza, Spain.", Journal of physiology and biochemistry, pp. S10-S11, ISSN: 1138-7548.
  • Casals, N; Zammit, V.; Herrero, L.; Fadó, R.; Rodriguez-Rodriguez, R.; Serra, D., (2016), "Carnitine palmitoyltransferase 1C: From cognition to cancer", Progress in lipid research, vol. 61, pp. 134-148, ISSN: 0163-7827.
  • Fadó, R.; Soto, D.; Minano-Molina, A.; Pozo Ariza, M; Carrasco, P.; Yefimenko, N.; Rodriguez-Alvarez, J.; Casals, N, (2015), "Novel Regulation of the Synthesis of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus", Journal of biological chemistry, vol. 290, No. 42, pp. 25548-25560, ISSN: 0021-9258.
  • Rinaldi, C.; Schmidt, T.; Situ, A.; Johnson, J.; Lee, P.; Ke-lian, C.; Bott, L.; Fadó, R.; Harmison, G.; Parodi, S.; Grunseich, C.; Renvoise, B.; Biesecker, L.; De Michele, G.; Santorelli, F.; Filla, A.; Stevanin, G.; Duerr, A.; Brice, A.; Casals, N; Traynor, B.; Blackstone, C.; Ulmer, T.; Fischbeck, K., (2015), "Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia", JAMA Neurology, vol. 72, No. 5, pp. 561-570, ISSN: 2168-6149.
  • Malandrino, M.; Fucho, R.; Weber, M.; Calderón Domínguez, M.; Mir, J.; Valcarcel, L.; Escote, X.; Gómez Serrano, M.; Peral, B.; Salvado, L.; Fernández Veledo, S.; Casals, N; Vázquez-Carrera, M.; Villarroya, F.; Vendrell, J.; Serra, D.; Herrero, L., (2015), "Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation", American journal of physiology. Endocrinology and metabolism, vol. 308, No. 9, ISSN: 0193-1849.
  • Contreras, C.; González García, I.; Martínez Sánchez, N.; Seoane Collazo, P.; Jacas Mateu, J; Morgan, D.; Serra, D.; Gallego, R.; González, F.; Casals, N; Nogueiras, R.; Rahmouni, K.; Dieguez, C.; López, M., (2014), "Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance", Cell Reports, vol. 9, No. 1, pp. 366-377, ISSN: 2211-1247.
  • Gao, S.; McMillan, R.; Jacas Mateu, J; Zhu, Q.; Li, X.; Kumar, G.; Casals, N; Hegardt, F.; Robbins, P.; Lopaschuk, G.; Hulver, M.; Butler, A., (2014), "Regulation of Substrate Oxidation Preferences in Muscle by the Peptide Hormone Adropin", Diabetes, vol. 63, No. 10, pp. 3242-3252, ISSN: 0012-1797.
  • Lamarca, A.; Gella, A.; Martiañez, T.; Segura, M.; Figueiro, J.; Grijota-Martinez,C.; Trullas, R.; Casals, N, (2014), "Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation", PLoS One, vol. 9, No. 6, ISSN: 1932-6203.
  • Hernández-Ortega, S; Bru, S.; Ricco, N.; Ramírez, S.; Casals, N; Jiménez, J.; Isasa, M.; Crosas, B.; Clotet, J., (2013), "Defective in Mitotic Arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.", The journal of biological chemistry (Versió web), vol. 288, No. 7, pp. 4704-4714, ISSN: 1083-351X.
  • Martiáñez, T.; Lamarca, A.; Casals, N; Gella, A., (2013), "N-cadherin expression is regulated by UTP in schwannoma cells", Purinergic Signalling, vol. 9, pp. 259-270, ISSN: 1573-9538.
  • Ramírez, S.; Martins, L.; Jacas Mateu, J; Carrasco, P.; Pozo Ariza, M; Clotet, J.; Serra, D.; Hegardt , FG.; Diéguez, C.; López, M.; Casals, N, (2013), "hypothalamic ceramide levels regulated by CPTC1C mediate the oxigenic effect of ghrelin", Diabetes, vol. 62, pp. 2329-2337, ISSN: 0012-1797.
  • Gao, S.; Casals, N; keung, W.; Moran, TH.; Lopaschuk, GD., (2013), "Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei", Physiology and behavior, vol. 118, pp. 165-170, ISSN: 0031-9384.
  • Carrasco, P.; Jacas Mateu, J; Sahún, I.; Muley, H.; Ramírez, S.; Puisac , B.; Mezquita, Pau; Pié, J.; Dierssen , M.; Casals, N, (2013), "Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity.", Behavioural brain research, vol. 256, pp. 291-297, ISSN: 0166-4328.
  • Arnedo, M.; Menao, S.; Puisac, B.; Teresa-Rodrigo, ME; Maria, E.; Gil-Rodríguez, M.; Maria, C.; López-Viñas, E.; Gómez-Puertas, P.; Casals, N; Casale, Cesar H.; Hegardt , FG., (2012), "Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol", Journal of lipid research, vol. 53, No. 10, pp. 2046-2056, ISSN: 0022-2275.
  • Puisac, B.; Ramos, M.; Arnedo, M.; Menao, S.; Gil-Rodríguez, M.; Teresa-Rodrigo, ME; Pié, A.; de Karam, JC; Wesselink, JJ; Giménez, I.; Ramos, FJ; Casals, N; Gómez-Puertas, P.; Hegardt , FG.; Pié, J., (2012), "Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway.", Mol Biol Rep, vol. 39, pp. 4777-4785.
  • Carrasco, P.; Sahún, I.; McDonald, J.; Ramírez, S.; Jacas Mateu, J; Gratacós, E.; Sierra, AY; Serra, D.; Herrero, L.; Acker-Palmer, A.; Hegardt , FG.; Dierssen , M.; Casals, N, (2012), "Ceramide levels regulated by carnitine palmitoyl transferase 1C control dendritic spine maturation and cognition.", Journal of biological chemistry, ISSN: 0021-9258.
  • Al-Atari Abou-Asi, M; Gil-Recio, C.; Fabregat, M.; García-Fernández, DA.; Barajas, M.; Carrasco, M.; Jung, H.; Hernandez Alfaro, F; Casals, N; Prósper, F.; Ferrés, E.; Giner Tarrida, L, (2012), "Dental Pulp of the Third Molar: A New Source of Pluripotent-like Stem Cells.", Journal of Cell Science, vol. 125, No. 14, pp. 3343-3356, ISSN: 0021-9533.
  • Gella, A.; Martiañez, T.; Lamarca, A.; Gutierrez, C.; Durany, N.; Casals, N, (2011), "A Nucleotide-Based Drug Protects against Glutamate- and MPP+-Induced Neurotoxicity", Neuroscience and Medicine, vol. 2, pp. 154-160.
  • Gao, S.; keung, W.; Serra, D.; Wang, W.; Carrasco, P.; Casals, N; Hegardt , FG.; Moran, TH.; Lopaschuk, GD., (2011), "Malonyl-CoA Mediates Leptin Hypothalamic Control of Feeding Independent of Inhibition of CPT-1a.", American journal of physiology. Regulatory integrative and comparative physiology, vol. 301, pp. 209-217, ISSN: 0363-6119.
  • Al-Atari Abou-Asi, M; Barajas, M.; Hernandez Alfaro, F; Gil-Recio, C.; Fabregat, M.; Ferrés, E.; Giner Tarrida, L; Casals, N, (2011), "Isolation of pluripotent stem cells from human third molar dental pulp", Histology and histopathology, vol. 26, No. 8, pp. 1057-1070, ISSN: 0213-3911.
  • Gao, S.; Zhu, G.; Gao, X.; Wu, D.; Carrasco, P.; Casals, N; keung, W.; Hegardt , FG.; Moran, TH.; Lopaschuk, GD., (2011), "Important Roles for Brain-specific Carnitine Palmitoyltransferase and Ceramide Metabolism in Leptin Hypothalamic Control of Feeding", Proceedings of the National Academy of Sciences of the United States of America, vol. 108, pp. 9691-9696, ISSN: 0027-8424.
  • Puisac, B.; Arnedo, M.; Casale, Cesar H.; Ribate, MP; Castiella, T.; Ramos, FJ; Ribes, A.; Pérez-Cerdá, C.; Casals, N; Hegardt , FG.; Pié, J., (2010), "Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria", Journal of inherited metabolic disease, vol. 33, No. 4, pp. 405-410, ISSN: 0141-8955.
  • Ferre, E.; Martí, C.; Hernandez Alfaro, F; Klein-Nulend, J.; Casals, N, (2010), "Buccal fat pad, an oral access-source of human adipose stem cells with potential for osteochondral tissue engineering, an in vitro study", Tissue engineering. Part A, tissue engineering, vol. 16, No. 5, pp. 1083-1095, ISSN: 1937-3341.
  • Pié, J.; Gil-Rodríguez, M.; Ciero, M.; López-Viñas, E.; Ribate, MP; Arnedo, M.; Deardorff, M.; Puisac, B.; Legarreta, J.; de Karam, JC; Egío, E.; Bueno, I.; Baldellou, A.; Calvo, MT; Casals, N; Olivares, JL; Losada, A.; Hegardt , FG., (2010), "Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome.", American Journal of Medical Genetics A, vol. 152A, pp. 924-929, ISSN: 1552-4833.
  • Menao, S.; López-Viñas, E.; Flores-Mir, C.; Puisac, B.; Gratacós, E.; Arnedo, M.; Carrasco, P.; Serra, D.; Asins, G.; Ramos, FJ; Gómez-Puertas, P.; Hegardt , FG.; Casals, N; Pié, J., (2009), "Ten Novel HMGCL Mutations in 24 Patients of Different Origin with 3-Hydroxy-3-Methyl-Glutaric Aciduria", Human mutation, vol. 3, pp. 520-529, ISSN: 1059-7794.
  • Sierra, A.; Gratacós, E.; Carrasco, P.; Clotet, J.; Ureña, J.; Serra, D.; Asins, G.; Hegardt, F.; Casals, N, (2008), "CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity", Journal of biological chemistry, vol. 283, No. 11, pp. 6878-6885, ISSN: 0021-9258.
  • Casals, N, (2007), "A new lc-esi-ms/ms method to measure acylcarnitine levels in cultured cells", Analytica chimica acta, vol. 599, pp. 1-6, ISSN: 0003-2670.
  • Casals, N, (2007), "Molecular genetics of HMG-CoA lyase deficiency", Molecular genetics and metabolism, vol. 92, pp. 198-209, ISSN: 1096-7192.
  • Casals, N, (2007), "C-Terminal end amd aminoacid Lys48in HMG-CoA lyase are involved in substrate binding and enzyme activity.", Molecular genetics and metabolism, vol. 91, pp. 120-127, ISSN: 1096-7192.
  • Casals, N, (2006), "Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency", Journal of inherited metabolic disease, vol. 29, pp. 207-211, ISSN: 0141-8955.
  • Casals, N, (2006), "A single residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase", Journal of inherited metabolic disease, vol. 29, pp. 64-70, ISSN: 0141-8955.
  • Casals, N, (2005), "Skipping of exon 2 and exon 2 plus 3 of HMG-CoA lyase (HL) gene produce the loss of beta sheet 1 and 2 at the recently proposed (beta-alfa)8 TIM barrel model of HL.", Biophysical chemistry, vol. 115, pp. 241-245, ISSN: 0301-4622.
  • Casals, N; Gómez-Puertas, P.; Pié, J.; Mir, C.; Roca, R.; Puisac, B.; Aledo, R.; Clotet, J.; Menao, S.; Serra, D.; Asins, G.; Till, J.; Alun, C.; Jones, E.; Cresto, Juan C.; Chamoles, Nestor A; Abdenur, Jose E; Mayatepek, E.; Besley, G.; Valencia, A.; Hegardt , FG., (2003), "Structural (beta alpha)(8) TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase", Journal of biological chemistry, vol. 278, No. 31, pp. 29016-29023, ISSN: 0021-9258.
  • Casals, N, (2003), "Molecular basis of 3-hydroxy 3-methylglutaric aciduria", Journal of physiology and biochemistry, vol. 59, pp. 311-322, ISSN: 1138-7548.
  • Morillas, M.; Bentebibel, A.; Selles, E.; Casals, N; Valencia, A.; Hegardt , FG.; Asins, G.; Serra, D.; Gómez-Puertas, P., (2003), "Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition", Journal of biological chemistry, vol. 278, pp. 9058-9063, ISSN: 0021-9258.
  • Muñoz, I.; Simón, E.; Casals, N; Clotet, J.; Ariño, J., (2003), "Identification of multicopy supressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae.", Yeast, vol. 30, pp. 157-169, ISSN: 0749-503X.
  • Mir, C.; Clotet, J.; Aledo, R.; Durany, N.; Argemí Renom, J; Lozano, R.; Cervós-Navarro, J.; Casals, N, (2003), "CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons", Journal of molecular neuroscience, vol. 20, pp. 53-59, ISSN: 0895-8696.
  • Casals, N, (2002), "Diagnosing mitochondrial HMG-CoA synthase deficiency", Journal of pediatrics, vol. 140, pp. 778-780, ISSN: 0022-3476.
  • Casals, N, (2001), "The genetic basis of mitochondrial HMG-CoA synthase deficiency", Human genetics, vol. 109, pp. 19-23, ISSN: 0340-6717.
  • Casals, N, (2001), "3-hydroxy-3-methylglutaryl CoA synthase-1 of Blattella germanica has structural and functional features of an active retrogene", Insect molecular biology, vol. 31, pp. 837-743, ISSN: 0962-1075.
  • Casals, N, (1998), "A nonsense mutation in the exon 2 of the 3-hydroxy-3-methylglutaryl CoA lyase (HL) gene producing three mature mRNAs is the main cause of 3-hydroxy-3-methylglutaric aciduria in european mediterranean patients", Archives of biochemistry and biophysics, vol. 349, ISSN: 0003-9861.
  • Casals, N, (1998), "Two missense point mutations in different alleles in the 3-hydroxy-3-methylglutaryl Coenzyme A Lyase gene produce 3-hydroxy-3methylglutaric aciduria in a french patient", Archives of biochemistry and biophysics, vol. 358, pp. 197-203, ISSN: 0003-9861.
  • Casals, N, (1997), "A two-base deletion in exon 6 of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene producing the skipping of exons 5 and 6 determines 3-hydroxy-3-methylglutaric aciduria", Journal of lipid research, vol. 38, pp. 90-100, ISSN: 0022-2275.
  • Casals, N, (1997), "A nonsense mutation in the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene produces exon-skipping in two patiens of different origin with hl deficiency", Biochemica journal, vol. 323, pp. 329-335, ISSN: 0264-6021.
  • Casals, N, (1997), "Expression and activity of 3-hydroxy-3-methylglutaryl-CoA synthase and reductase in the fat body of ovariectomized and allatectomized Blattella germanica", Physiological entomology, vol. 22, pp. 6-12, ISSN: 0307-6962.
  • Casals, N, (1996), "La prescripción farmacéutica en Catalunya tras el decreto de financiación selectiva de medicamentos", Gaceta sanitaria, vol. 10, pp. 183-190, ISSN: 0213-9111.
  • Casals, N, (1996), "Coordinated Expression and Activity of 3-hydroxy-3-methylglutaryl CoA synthase and reductase in the fat body of Blattella germanica during vitellogenesis", Insect molecular biology, vol. 26, pp. 837-843, ISSN: 0962-1075.
  • Casals, N, (1996), "An aberrant splicing by a point mutation and a deletion in 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene produce an hereditary hl deficiency", Journal of lipid research, vol. 37, pp. 2420-2431, ISSN: 0022-2275.
  • Casals, N, (1994), "Blattella germanica Has Two HMG-CoA Synthase Genes. Both Are Regulated In The Ovarian Development", Journal of biological chemistry, vol. 269, pp. 11707-11713, ISSN: 0021-9258.
  • Casals, N, (1993), "Regulation of Mitochondrial 3-Hydroxy-3-Methylglutaryl-coenzime A Synthase Protein by Starvation, Fat Feeding and Diabetes", Archives of biochemistry and biophysics, vol. 307, pp. 40-45, ISSN: 0003-9861.
  • Casals, N, (1992), "Regulation of the expression of the mitochondrial 3-hidroxy-3-methylglutaryl-CoA synthase gene", Biochemica journal, vol. 283, ISSN: 0264-6021.
  • Casals, N, (2008), "El DNA es pot manipular.". Institut d'Estudis Catalans..

Proyectos de investigación

    IP: Casals, N; Rodriguez-Rodriguez, R.
    Ministerio de Ciencia e Innovación (MICINN)
  • Administracion de fármacos específicos de la CPT1 central: una novedosa estrategia basada en nanomedicina para combatir obesidad y cáncer01/01/2019 - 31/12/2021
    IP: Rodriguez-Rodriguez, R.
  • Cpt1c en el hipotálamo ventromedial como nueva diana terapéutica en la regulación del balance energético: mecanismos moleculares implicados01/01/2018 - 31/12/2020
    IP: Casals, N; Rodriguez-Rodriguez, R.
    Ministerio de Economía, Industria y Competitividad
  • Carnitine palmitoyltransferase 1-mediated strategies to activate brown fat and reduce food intake to fight against obesity01/03/2017 - 01/03/2020
    IP: Casals, N; Serra, D.
    Fundació la Marató de TV3
  • Regulation of Lipid Metabolism in Obesity and Diabetes (METALIP)01/01/2017 - 31/12/2019
    IP: Casals, N
    Agencia de Gestió d'ajudas Universitaries Investigació AGAUR
  • Papel de la carnitina pamitoil transferasa 1C como sensor hipotalámico de aciles-CoA y regulador del metabolismo periférico de los lípidos (SAF2014-52223-C2-2-R)01/01/2015 - 31/12/2017
    IP: Casals, N
    Ministerio de Ciencia e Innovación (MICINN)
  • Searching new biomarkers and therapeutic targets related to cognitive deficits in early stages of Alzheimer's Disease: Role of AKAP79/150, CPT1C and SSAO/VAP-1 in Abmediated AMPAR dysfunction.01/01/2015 - 31/12/2017
    IP: Casals, N; Rodríguez , J.
    Fundació la Marató de TV3
  • Participación de CPT1C en la síntesis de ceramidas y el control de la ingesta alimentaria01/01/2012 - 31/12/2014
    IP: Casals, N
    Ministerio de Economía y Competitividad
  • Homeostasi Energètica26/11/2009 - 31/12/2014
    IP: Casals, N
    Generalitat de Catalunya
  • Bases moleculars de acción de las carnitina aciltransferasas como reguladoras de la oxidación de las grasas y su papel en la obesidad, la resistencia a la insulina y el apetito01/01/2008 - 31/12/2012
    IP: Hegardt , FG.
    Ministerio de Ciencia y Tecnología
  • Càtedra cultura, ciència i religió01/09/2013 - 31/08/2016
    IP: Corcó, Josep
  • Efecto del Nucleo CMP Forte en la regeneración neuronal del Sistema Nervioso Periférico01/05/2011 - 01/05/2012
    IP: Casals, N
    Laboratorios Farmacéuticos Ferrer-Internacional
  • Neuroprotección del núcleo CMP forte en células nerviosas01/01/2006 - 31/12/2007
    IP: Casals, N
    Laboratorios Farmacéuticos Ferrer-Internacional
  • Estudio del papel neuroprotector de la CDP-colina en la muerte neuronal inducida por el péptido beta-amiloide y el NO01/01/2002 - 31/12/2003
    IP: Casals, N
    Laboratorios Farmacéuticos Ferrer-Internacional
  • Estudio del papel de la CDP-colina en la reducción de la apopotosis neuronal inducida por excitotoxicidad01/01/1999 - 31/12/2000
    IP: Casals, N
    Laboratorios Farmacéuticos Ferrer-Internacional


  • Reunión Anual de la Sociedad Española de Investigación sobre Cannabinoides Presentació de poster "CPT1C AS THE FIRST NEGATIVE REGULATOR OF THE ENDOCANNABINOIDS α/β-HYDROLASE CONTAINING 6 (ABHD6)", 2019.
  • MetNet Annual Meeting: Targeting Metabolism to Develop New Therapies Presentació de comunicació "Carnitine palmitoyltransferase 1C as the first negative regulator of the endocannabinoids hydrolase ABHD6", 2019.
  • EMBO Workshop- Organ crosstalk in energy balance and metabolic disease Presentació de poster "The dynamic of endocannabinoid levels in the hypothalamus negatively correlates with obesity development in male and female mice", 2019.
  • Copenhagen Bioscience Conference- Metabolism in action Presentació de poster "Deciphering the cross-talk relationship between brown fat thermogenesis and hypothalamic endocannabinoid dynamics during obesity development", 2019.
  • Gordon Research Conference on Cannabinoid Function in the CNS Presentació de comunicació "CPT1C: a novel regulator of ABHD6 activity", 2019.
  • Gordon Research Conference on Cannabinoid Function in the CNS Presentació de poster "The dynamic of endocannabinoids in the hypothalamus during obesity development in male and female mice and its cross-talk to Brown fat thermogenesis", 2019.
  • Copenhagen Bioscience Conference Presentació de poster "Brain specific CPT1C is involved in the hypothalamic regulation of brown fat thermogenesis by endocannabinoids-dependent mechanisms", 2017.
  • Congreso de la Sociedad Española de Neurociencia Ponència "Regulation of high fat diet and leptin induced thermogenesis by hypothalamic CPT1C", 2017.
  • Congreso de la Sociedad Española de Farmacología Presentació de poster "Brain specific carnitine palmitoyltransferase 1C (CPT1C) is involved in the hypothalamic regulation of thermogenesis by endocannabinoids-dependent mechanisms", 2017.