Directorio
FADÓ ANDRÉS, Rut
FADÓ ANDRÉS, Rut
CV
Perfil del profesor
Professor Contractat Doctor
Ciencias Básicas, DEPARTAMENTO DE CIENCIAS BÁSICAS. Universitat Internacional de Catalunya
Formación académica
- BIOQUÍMICA Universitat Autònoma de Barcelona
- CERTIFICADO DE APTITUD PEDAGOGICA INSITUTO DE CIENCIAS DE LA EDUCACIÓN
- DIPLOMA DE ESTUDIOS AVANZADOS EN BIOQUIMICA Y BIOLOGIA MOLECULAR DEPARTAMENT DE BIOQUÍMICA I BIOLOGIA MOLECULAR
- LLICENCIAT EN BIOQUÍMICA Universitat Autònoma de Barcelona
Publicaciones
Artículos
- Fadó, R.; Molins, A.; Rojas, R.; Casals, N, (2022), "Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors", Nutrients, vol. 14, ISSN: 2072-6643.
- Fadó, R.; Rodriguez-Rodriguez, R.; Casals, N, (2021), "The return of malonyl-CoA to the brain: Cognition and other stories", Progress in lipid research, vol. 81, ISSN: 0163-7827.
- Casas, M.; Fadó, R.; Domínguez, J.L.; Roig, A.; Kaku, M.; Chohnan, S.; Solé, M.; Unzeta, M.; Miñano-Molina, A.; Rodríguez, J.; Dickson, E.; Casals, N, (2020), "Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking", Journal of cell biology, vol. 219, No. 10, ISSN: 0021-9525.
- Muley, H.; Fadó, R.; Rodriguez-Rodriguez, R.; Casals, N, (2020), "Drug uptake-based chemoresistance in breast cancer treatment", Biochemica pharmacology, vol. 177, ISSN: 0006-2952.
- Cheng, W.; Siedlecki-Wullich, D.; Català-Solsona, J.; Fàbregas, C.; Fadó, R.; Casals, N; Solé, M.; Unzeta, M.; Saura, C.; Rodríguez, J.; Miñano-Molina, A., (2020), "Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD", eNeuro, vol. 7, No. 2, ISSN: 2373-2822.
- Palomo-Guerrero, M.; Fadó, R.; Casas, M.; Pérez-Montero, M.; Baena, M.; Helmer, PO.; Domínguez, JL.; Roig, A.; Serra, D.; Hayen, H.; Stenmark, H.; Raiborg, C.; Casals, N, (2019), "Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth", eLife, vol. 8, ISSN: 2050-084X.
- Solé, M.; Esteban, M.; Taltavull, B.; Fàbregas, C.; Fadó, R.; Casals, N; Rodríguez, J.; Miñano-Molina, A.; Unzeta, M., (2019), "Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition", Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1865, No. 9, pp. 2189-2202, ISSN: 1879-260X 09254439.
- Gratacós, E.; Olivella, M.; Sánchez, N.; Yefimenko, N.; Miguez, F.; Fadó, R.; Casals, N; Gasull, X.; Ambrosio, S.; Soto, D., (2018), "Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement", Frontiers in Molecular Neuroscience, vol. 11, No. 275, ISSN: 1662-5099.
- Roa, X.; Al-Atari Abou-Asi, M; Fadó, R.; Mir, J.; Muley, H.; Serra, D.; Casals, N, (2018), "CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy", Scientific Reports, vol. 8, ISSN: 2045-2322.
- Palomo-Guerrero, M.; Fadó, R.; Moreno, B.; Rodríguez-Rodríguez, R.; Casals, N, (2016), "Abstracts of the XXXVIII Congress of the Spanish Society of Physiological Sciences (SECF), 13-16 September 2016, Zaragoza, Spain.", Journal of physiology and biochemistry, pp. S10-S11, ISSN: 1138-7548.
- Casals, N; Zammit, V.; Herrero, L.; Fadó, R.; Rodriguez-Rodriguez, R.; Serra, D., (2016), "Carnitine palmitoyltransferase 1C: From cognition to cancer", Progress in lipid research, vol. 61, pp. 134-148, ISSN: 0163-7827.
- Fadó, R.; Soto, D.; Miñano-Molina, A.; Pozo Ariza, M; Carrasco, P.; Yefimenko, N.; Rodriguez-Alvarez, J.; Casals, N., (2015), "Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus.", Journal of biological chemistry, vol. 42, No. 290, pp. 25548-25560, ISSN: 0021-9258.
- Fadó, R.; Soto, D.; Minano-Molina, A.; Pozo Ariza, M; Carrasco, P.; Yefimenko, N.; Rodriguez-Alvarez, J.; Casals, N, (2015), "Novel Regulation of the Synthesis of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus", Journal of biological chemistry, vol. 290, No. 42, pp. 25548-25560, ISSN: 0021-9258.
- Rinaldi, C.; Schmidt, T.; Situ, A.; Johnson, J.; Lee, P.; Ke-lian, C.; Bott, L.; Fadó, R.; Harmison, G.; Parodi, S.; Grunseich, C.; Renvoise, B.; Biesecker, L.; De Michele, G.; Santorelli, F.; Filla, A.; Stevanin, G.; Duerr, A.; Brice, A.; Casals, N; Traynor, B.; Blackstone, C.; Ulmer, T.; Fischbeck, K., (2015), "Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia", JAMA Neurology, vol. 72, No. 5, pp. 561-570, ISSN: 2168-6149.
- Blancas, S.; Fadó, R.; Rodríguez-Alvarez, J.; Moran, J., (2014), "Endogenous XIAP, but not other members of the inhibitory apoptosis protein family modulates cerebellar granule neurons survival", International journal of developmental neuroscience, vol. 37, pp. 26-36, ISSN: 0736-5748.
- Jiménez, J.; Ricco, N.; Grijota-Martinez,C.; Fadó, R.; Clotet, J., (2013), "Redundancy or specificity? The role of the CDK Pho85 in cell cycle control", International Journal of Biochemistry and Molecular Biology, vol. 4, No. 3, pp. 140-149, ISSN: 2152-4114.
- Fadó, R.; Moubarak, R.; Miñano-Molina, A.; Barneda-Zahonero, B.; Valero, J.; Saura, C.; Moran, J.; Comella, J.; Rodríguez-Alvarez, J., (2013), "X-linked inhibitor of apoptosis protein negatively regulates neuronal differentiation through interaction with cRAF and Trk", Scientific Reports, vol. 3, No. 2397, pp. 1-11, ISSN: 2045-2322.
- Barneda-Zahonero, B.; Servitja, J.; Badiola, N.; Miñano-Molina, A.; Fadó, R.; Saura, C.; Rodríguez-Alvarez, J., (2012), "NURR1 IS REQUIRED FOR NMDA RECEPTOR-MEDIATED NEURONAL SURVIVAL", Journal of biological chemistry, vol. 287, pp. 11351-11362, ISSN: 0021-9258.
- Badiola, N.; Penas, C.; Miñano-Molina, A.; Barneda-Zahonero, B.; Fadó, R.; Sánchez-Opazo, G.; Comella, J.; Sabria, J.; Zhu, C.; Blomgren, K.; Casas, C.; Rodríguez-Alvarez, J., (2011), "Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12", Cell death and disease, vol. 2, ISSN: 2041-4889.
- Miñano-Molina, A.; España, J.; Martín, E.; Barneda-Zahonero, B.; Fadó, R.; Solé, M.; Trullás, R.; Rodríguez-Alvarez, J., (2011), "SOLUBLE OLIGOMERS OF AMYLOID-BETA PEPTIDE DISRUPT MEMBRANE TRAFFICKING OF AMPA RECEPTORS CONTRIBUTING TO EARLY SYNAPSE DYSFUNCTION", Journal of biological chemistry, vol. 286, pp. 27311-27321, ISSN: 0021-9258.
- Barneda-Zahonero, B.; Miñano-Molina, A.; Badiola, N.; Fadó, R.; Xifro, X.; Saura, C.; Rodríguez-Alvarez, J., (2009), "BMP-6 PROMOTES CEREBELLAR GRANULE NEURONS SURVIVAL BY ACTIVATION OF THE MEK/ERK/CREB PATHWAY", Molecular biology of the cell, vol. 20, pp. 5051-5063, ISSN: 1059-1524.
- Xifro, X.; Falluel-Morell, A.; Miñano-Molina, A.; Aubert, N.; Fadó, R.; Malagelada, C.; Vaudry, D.; Vaudry, H.; Gonzalez, B.; Rodríguez-Alvarez, J., (2005), "N-METHYL-D-ASPARTATE BLOCKS ACTIVATION OF JNK AND MITOCHONDRIAL APOPTOTIC PATHWAY INDUCED BY POTASSIUM DEPRIVATION IN CEREBELLAR GRANULE CELLS", Journal of biological chemistry, vol. 281, pp. 6801-6812, ISSN: 0021-9258.
Proyectos de investigación
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Administracion de fármacos específicos de la CPT1 central: una novedosa estrategia basada en nanomedicina para combatir obesidad y cáncer01/01/2019 - 31/12/2021IP: Rodriguez-Rodriguez, R.
MINISTERIO DE CIENCIA E INNOVACION
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Cpt1c en el hipotálamo ventromedial como nueva diana terapéutica en la regulación del balance energético: mecanismos moleculares implicados01/01/2018 - 31/12/2020IP: Casals, N; Rodriguez-Rodriguez, R.
Ministerio de Economía, Industria y Competitividad
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Carnitine palmitoyltransferase 1-mediated strategies to activate brown fat and reduce food intake to fight against obesity01/03/2017 - 01/03/2020IP: Casals, N; Serra, D.
Fundació la Marató de TV3
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Regulation of Lipid Metabolism in Obesity and Diabetes (METALIP)01/01/2017 - 31/12/2019IP: Casals, N
Agencia de Gestió d'ajudas Universitaries Investigació AGAUR
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Papel de la carnitina pamitoil transferasa 1C como sensor hipotalámico de aciles-CoA y regulador del metabolismo periférico de los lípidos (SAF2014-52223-C2-2-R)01/01/2015 - 31/12/2017IP: Casals, N
Ministerio de Ciencia e Innovación (MICINN)
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Searching new biomarkers and therapeutic targets related to cognitive deficits in early stages of Alzheimer's Disease: Role of AKAP79/150, CPT1C and SSAO/VAP-1 in Abmediated AMPAR dysfunction.01/01/2015 - 31/12/2017IP: Casals, N; Rodríguez , J.
Fundació la Marató de TV3
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Participación de CPT1C en la síntesis de ceramidas y el control de la ingesta alimentaria01/01/2012 - 31/12/2014IP: Casals, N
Ministerio de Economía y Competitividad
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Homeostasi Energètica26/11/2009 - 31/12/2014IP: Casals, N
Generalitat de Catalunya
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Regulación de la señalización mediada por los receptores con dominios de muerte por antagonistas y miRNAs como estrategia protectora en la isquemia cerebral01/01/2012 - 01/01/2014IP: Rodríguez-Alvarez, J.
MINISTERIO DE CIENCIA E INNOVACION
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Mecanismos de muerte celular01/01/2009 - 01/01/2013IP: Rodríguez-Alvarez, J.
Agència de Gestió d'ajuts universitaris i de recerca de la Generalitat
Actividades
- SIMPOSI FUNDACIÓ LA MARATÓ DE TV3: Malalties neurodegeneratives Ponència "Searching new biomarkers and therapeutic targets related to cognitive deficits in eAD: Role of AKAP79/150, CPT1C and SSAO/VAP-1 in Aβ-mediated AMPAR dysfunction", 2019.
- SEBBM Congress Ponència "Rol de la Carnitina Palmitoil Transferasa 1 (CPT1C) en sobrevivencia de la células madre mesenquimales", 2017.
- X Simposi de Neurobiología de la Societat Catalana de Biologia Presentació de poster "Regulation of AMPA receptor trafficking by CPT1C", 2016.
- Congreso de la Sociedad Española de Ciencias Fisiológicas Ponència convidada "Hereditary spastic paraplegia (HSP), and endoplasmic reticulum disease", 2016.
- Congreso de la Sociedad Española de Neurociencia Presentació de poster "AMPA receptor expression regulation by CPT1C in hippocampus", 2015.
- Simposi de Neurobiologia Experimental Ponència "SPECIFIC REGULATION OF GLUA SUBUNIT SYNTHESIS AND AMPA RECEPTOR-MEDIATED SYNAPTIC FUNCTION BY CPT1C IN THE HIPPOCAMPUS", 2014.
- FENS FORUM OF NEUROSCIENCE Ponència "Role of death receptors regulation on cell damage induced by oxygen-glucose deprivation in cortical cultures", 2014.
- International Congress on Ceramides Ponència "The role of the neural protein CPT1C on the ceramide synthesis", 2013.
- Biennial Joint Meeting of International Society for Neurochemistry and American Society for Neurochemistry Presentació de poster "X-linked inhibitor of apoptosis protein negatively regulates neuronal differentiation through interaction with cRAF and Trk", 2013.
- Congreso bienal de la Sociedad Española de Neurociencias Presentació de poster "HOW IAPS DOWNREGULATION INDUCE NEURITE OUTGROWTH IN PC12", 2009.
