Directori
FADÓ ANDRÉS, Rut
Ext. 5225
Departament de Ciències Bàsiques
From cell metabolism to metabolic diseases (METADIS)
FADÓ ANDRÉS, Rut
CV
Perfil del professor
Professor Contractat Doctor
Ciències Bàsiques, DEPARTAMENT DE CIÈNCIES BÀSIQUES. Universitat Internacional de Catalunya
Formació Acadèmica
- BIOQUÍMICA Universitat Autònoma de Barcelona
- CERTIFICADO DE APTITUD PEDAGOGICA INSITUTO DE CIENCIAS DE LA EDUCACIÓN
- DIPLOMA DE ESTUDIOS AVANZADOS EN BIOQUIMICA Y BIOLOGIA MOLECULAR DEPARTAMENT DE BIOQUÍMICA I BIOLOGIA MOLECULAR
- LLICENCIAT EN BIOQUÍMICA Universitat Autònoma de Barcelona
Publicacions
Articles
- Fadó, R.; Zagmutt, S.; Herrero, L.; Muley, H.; Rodriguez-Rodriguez, R.; Bi, H.; Serra, D.; Casals, N, (2023), "To be or not to be a fat burner, that is the question for cpt1c in cancer cells", Cell death and disease, vol. 14, No. 1, ISSN: 2041-4889.
- Muley, H.; Valencia, K.; Casas, J.; Moreno, B.; Botella, L.; Lecanda, F.; Fadó, R.; Casals, N, (2023), "Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer", International Journal of Molecular Sciences, vol. 24, No. 2, ISSN: 1422-0067.
- Fadó, R.; Molins, A.; Rojas, R.; Casals, N, (2022), "Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors", Nutrients, vol. 14, No. 19, ISSN: 2072-6643.
- Fadó, R.; Rodriguez-Rodriguez, R.; Casals, N, (2021), "The return of malonyl-CoA to the brain: Cognition and other stories", Progress in lipid research, vol. 81, ISSN: 0163-7827.
- Casas, M.; Fadó, R.; Domínguez, J.L.; Roig, A.; Kaku, M.; Chohnan, S.; Solé, M.; Unzeta, M.; Miñano-Molina, A.; Rodríguez, J.; Dickson, E.; Casals, N, (2020), "Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking", Journal of cell biology, vol. 219, No. 10, ISSN: 0021-9525.
- Muley, H.; Fadó, R.; Rodriguez-Rodriguez, R.; Casals, N, (2020), "Drug uptake-based chemoresistance in breast cancer treatment", Biochemica pharmacology, vol. 177, ISSN: 0006-2952.
- Cheng, W.; Siedlecki-Wullich, D.; Català-Solsona, J.; Fàbregas, C.; Fadó, R.; Casals, N; Solé, M.; Unzeta, M.; Saura, C.; Rodríguez, J.; Miñano-Molina, A., (2020), "Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD", eNeuro, vol. 7, No. 2, ISSN: 2373-2822.
- Palomo-Guerrero, M.; Fadó, R.; Casas, M.; Pérez-Montero, M.; Baena, M.; Helmer, PO.; Domínguez, JL.; Roig, A.; Serra, D.; Hayen, H.; Stenmark, H.; Raiborg, C.; Casals, N, (2019), "Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth", eLife, vol. 8, ISSN: 2050-084X.
- Solé, M.; Esteban, M.; Taltavull, B.; Fàbregas, C.; Fadó, R.; Casals, N; Rodríguez, J.; Miñano-Molina, A.; Unzeta, M., (2019), "Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition", Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1865, No. 9, pp. 2189-2202, ISSN: 1879-260X 09254439.
- Gratacós, E.; Olivella, M.; Sánchez, N.; Yefimenko, N.; Miguez, F.; Fadó, R.; Casals, N; Gasull, X.; Ambrosio, S.; Soto, D., (2018), "Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement", Frontiers in Molecular Neuroscience, vol. 11, No. 275, ISSN: 1662-5099.
- Roa, X.; Al-Atari Abou-Asi, M; Fadó, R.; Mir, J.; Muley, H.; Serra, D.; Casals, N, (2018), "CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy", Scientific Reports, vol. 8, ISSN: 2045-2322.
- Palomo-Guerrero, M.; Fadó, R.; Moreno, B.; Rodríguez-Rodríguez, R.; Casals, N, (2016), "Abstracts of the XXXVIII Congress of the Spanish Society of Physiological Sciences (SECF), 13-16 September 2016, Zaragoza, Spain.", Journal of physiology and biochemistry, pp. S10-S11, ISSN: 1138-7548.
- Casals, N; Zammit, V.; Herrero, L.; Fadó, R.; Rodriguez-Rodriguez, R.; Serra, D., (2016), "Carnitine palmitoyltransferase 1C: From cognition to cancer", Progress in lipid research, vol. 61, pp. 134-148, ISSN: 0163-7827.
- Fadó, R.; Soto, D.; Miñano-Molina, A.; Pozo Ariza, M; Carrasco, P.; Yefimenko, N.; Rodriguez-Alvarez, J.; Casals, N., (2015), "Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus.", Journal of biological chemistry, vol. 42, No. 290, pp. 25548-25560, ISSN: 0021-9258.
- Fadó, R.; Soto, D.; Minano-Molina, A.; Pozo Ariza, M; Carrasco, P.; Yefimenko, N.; Rodriguez-Alvarez, J.; Casals, N, (2015), "Novel Regulation of the Synthesis of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus", Journal of biological chemistry, vol. 290, No. 42, pp. 25548-25560, ISSN: 0021-9258.
- Rinaldi, C.; Schmidt, T.; Situ, A.; Johnson, J.; Lee, P.; Ke-lian, C.; Bott, L.; Fadó, R.; Harmison, G.; Parodi, S.; Grunseich, C.; Renvoise, B.; Biesecker, L.; De Michele, G.; Santorelli, F.; Filla, A.; Stevanin, G.; Duerr, A.; Brice, A.; Casals, N; Traynor, B.; Blackstone, C.; Ulmer, T.; Fischbeck, K., (2015), "Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia", JAMA Neurology, vol. 72, No. 5, pp. 561-570, ISSN: 2168-6149.
- Blancas, S.; Fadó, R.; Rodríguez-Alvarez, J.; Moran, J., (2014), "Endogenous XIAP, but not other members of the inhibitory apoptosis protein family modulates cerebellar granule neurons survival", International journal of developmental neuroscience, vol. 37, pp. 26-36, ISSN: 0736-5748.
- Jiménez, J.; Ricco, N.; Grijota-Martinez,C.; Fadó, R.; Clotet, J., (2013), "Redundancy or specificity? The role of the CDK Pho85 in cell cycle control", International Journal of Biochemistry and Molecular Biology, vol. 4, No. 3, pp. 140-149, ISSN: 2152-4114.
- Fadó, R.; Moubarak, R.; Miñano-Molina, A.; Barneda-Zahonero, B.; Valero, J.; Saura, C.; Moran, J.; Comella, J.; Rodríguez-Alvarez, J., (2013), "X-linked inhibitor of apoptosis protein negatively regulates neuronal differentiation through interaction with cRAF and Trk", Scientific Reports, vol. 3, No. 2397, pp. 1-11, ISSN: 2045-2322.
- Barneda-Zahonero, B.; Servitja, J.; Badiola, N.; Miñano-Molina, A.; Fadó, R.; Saura, C.; Rodríguez-Alvarez, J., (2012), "NURR1 IS REQUIRED FOR NMDA RECEPTOR-MEDIATED NEURONAL SURVIVAL", Journal of biological chemistry, vol. 287, pp. 11351-11362, ISSN: 0021-9258.
- Badiola, N.; Penas, C.; Miñano-Molina, A.; Barneda-Zahonero, B.; Fadó, R.; Sánchez-Opazo, G.; Comella, J.; Sabria, J.; Zhu, C.; Blomgren, K.; Casas, C.; Rodríguez-Alvarez, J., (2011), "Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12", Cell death and disease, vol. 2, ISSN: 2041-4889.
- Miñano-Molina, A.; España, J.; Martín, E.; Barneda-Zahonero, B.; Fadó, R.; Solé, M.; Trullás, R.; Rodríguez-Alvarez, J., (2011), "SOLUBLE OLIGOMERS OF AMYLOID-BETA PEPTIDE DISRUPT MEMBRANE TRAFFICKING OF AMPA RECEPTORS CONTRIBUTING TO EARLY SYNAPSE DYSFUNCTION", Journal of biological chemistry, vol. 286, pp. 27311-27321, ISSN: 0021-9258.
- Barneda-Zahonero, B.; Miñano-Molina, A.; Badiola, N.; Fadó, R.; Xifro, X.; Saura, C.; Rodríguez-Alvarez, J., (2009), "BMP-6 PROMOTES CEREBELLAR GRANULE NEURONS SURVIVAL BY ACTIVATION OF THE MEK/ERK/CREB PATHWAY", Molecular biology of the cell, vol. 20, pp. 5051-5063, ISSN: 1059-1524.
- Xifro, X.; Falluel-Morell, A.; Miñano-Molina, A.; Aubert, N.; Fadó, R.; Malagelada, C.; Vaudry, D.; Vaudry, H.; Gonzalez, B.; Rodríguez-Alvarez, J., (2005), "N-METHYL-D-ASPARTATE BLOCKS ACTIVATION OF JNK AND MITOCHONDRIAL APOPTOTIC PATHWAY INDUCED BY POTASSIUM DEPRIVATION IN CEREBELLAR GRANULE CELLS", Journal of biological chemistry, vol. 281, pp. 6801-6812, ISSN: 0021-9258.
Projectes de recerca
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Administracion de fármacos específicos de la CPT1 central: una novedosa estrategia basada en nanomedicina para combatir obesidad y cáncer01/01/2019 - 31/12/2021IP: Rodriguez-Rodriguez, R.
MINISTERIO DE CIENCIA E INNOVACION
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Cpt1c en el hipotálamo ventromedial como nueva diana terapéutica en la regulación del balance energético: mecanismos moleculares implicados01/01/2018 - 31/12/2020IP: Casals, N; Rodriguez-Rodriguez, R.
Ministerio de Economía, Industria y Competitividad
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Carnitine palmitoyltransferase 1-mediated strategies to activate brown fat and reduce food intake to fight against obesity01/03/2017 - 01/03/2020IP: Casals, N; Serra, D.
Fundació la Marató de TV3
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Regulation of Lipid Metabolism in Obesity and Diabetes (METALIP)01/01/2017 - 31/12/2019IP: Casals, N
Agencia de Gestió d'ajudas Universitaries Investigació AGAUR
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Papel de la carnitina pamitoil transferasa 1C como sensor hipotalámico de aciles-CoA y regulador del metabolismo periférico de los lípidos (SAF2014-52223-C2-2-R)01/01/2015 - 31/12/2017IP: Casals, N
Ministerio de Ciencia e Innovación (MICINN)
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Searching new biomarkers and therapeutic targets related to cognitive deficits in early stages of Alzheimer's Disease: Role of AKAP79/150, CPT1C and SSAO/VAP-1 in Abmediated AMPAR dysfunction.01/01/2015 - 31/12/2017IP: Casals, N; Rodríguez , J.
Fundació la Marató de TV3
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Participación de CPT1C en la síntesis de ceramidas y el control de la ingesta alimentaria01/01/2012 - 31/12/2014IP: Casals, N
Ministerio de Economía y Competitividad
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Homeostasi Energètica26/11/2009 - 31/12/2014IP: Casals, N
Generalitat de Catalunya
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Regulación de la señalización mediada por los receptores con dominios de muerte por antagonistas y miRNAs como estrategia protectora en la isquemia cerebral01/01/2012 - 01/01/2014IP: Rodríguez-Alvarez, J.
MINISTERIO DE CIENCIA E INNOVACION
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Mecanismos de muerte celular01/01/2009 - 01/01/2013IP: Rodríguez-Alvarez, J.
Agència de Gestió d'ajuts universitaris i de recerca de la Generalitat
Activitats
- Women in Autophagy Annual Synposium Webinar Presentació de ponència curta (short paper) "Regulation of autophagy by the CPT1C-SAC1 complex in neurons", 2022.
- Sefagia Presentació de poster "Regulation of autophagy by the CPT1C-SAC1 complex in neurons", 2022.
- EMBO Workshop Autophagy in brain health and disease Presentació de poster "Regulation of autophagy by the CPT1C-SAC1 complex in neurons", 2022.
- SIMPOSI FUNDACIÓ LA MARATÓ DE TV3: Malalties neurodegeneratives Ponència "Searching new biomarkers and therapeutic targets related to cognitive deficits in eAD: Role of AKAP79/150, CPT1C and SSAO/VAP-1 in Aβ-mediated AMPAR dysfunction", 2019.
- SEBBM Congress Ponència "Rol de la Carnitina Palmitoil Transferasa 1 (CPT1C) en sobrevivencia de la células madre mesenquimales", 2017.
- X Simposi de Neurobiología de la Societat Catalana de Biologia Presentació de poster "Regulation of AMPA receptor trafficking by CPT1C", 2016.
- Congreso de la Sociedad Española de Ciencias Fisiológicas Ponència convidada "Hereditary spastic paraplegia (HSP), and endoplasmic reticulum disease", 2016.
- Congreso de la Sociedad Española de Neurociencia Presentació de poster "AMPA receptor expression regulation by CPT1C in hippocampus", 2015.
- Simposi de Neurobiologia Experimental Ponència "SPECIFIC REGULATION OF GLUA SUBUNIT SYNTHESIS AND AMPA RECEPTOR-MEDIATED SYNAPTIC FUNCTION BY CPT1C IN THE HIPPOCAMPUS", 2014.
- FENS FORUM OF NEUROSCIENCE Ponència "Role of death receptors regulation on cell damage induced by oxygen-glucose deprivation in cortical cultures", 2014.