Back to the directory
Our teaching and research team
ZAGMUTT CAROCA, Sebastián Ignacio

ZAGMUTT CAROCA, Sebastián Ignacio

Professor Professor in Tenure Track
Faculty of Medicine and Health Sciences
Department of Biomedical Sciences
From cell metabolism to metabolic diseases (METADIS)

Contact

szagmutt@uic.es
ORCID
  • Academic training
  • Projects
    • Competitive
  • Publications
    • Articles
  • Subjects taught
  • Tecnología Médica
  • Universidad de Talca
  • Master Ciencias Biomédicas
  • Universidad de Talca
  • Doctorado en Biotecnología
  • Universidad de Barcelona

Doctor in Biotechnology, UNIVERSITAT DE BARCELONA
Master in Biomedical Sciences: Clinical Biochemistry and Immunohematology, UNIVERSIDAD DE CHILE
Graduated Medical Technologist, UNIVERSIDAD DE CHILE
Graduate in Medical Technology, UNIVERSIDAD DE CHILE
Diploma in Competency-Based Higher Education, UNIVERSIDAD DE CHILE
  • GerOMIC: Unveiling Biomarker-Based Strategies for Healthy Aging (Espera de Resolución)
    PI: Zagmutt, S.; Bosch, J. Start date: 05/01/2026 End date: 05/03/2029
    Financing entity: Universitat Internacional de Catalunya Financing entity code: Instituto de Salud Carlos III (ISCIII)
  • Proteínas CPT1 en el hipotálamo: Descifrando la percepción de grasas saturadas y no saturadas y sus implicaciones en el desarrollo de la obesidad
    PI: Casals, N; Rodriguez-Rodriguez, R. Start date: 01/09/2024 End date: 31/08/2027
    Financing entity: MINISTERIO DE CIENCIA E INNOVACION Financing entity code: PID2023-146716OB-I00
  • Response to an intervention with Omega-3 fatty acids on lipid and inflammatory profile in overweight and hypertriglyceridemic individuals in Valdivia, Chile. (RIO-study)
    PI: Sandoval, V. Start date: 08/01/2024 End date: 04/01/2027
    Financing entity: FONDECYT - Agencia Nacional de Investigación y Desarrollo del Ministerio de Ciencia, Tecnología, Conocimiento e Innovación de Chile Financing entity code: 11241108
  • Protein-based nanoparticles for nose-to-brain delivery to treat obesity (Producte)
    PI: Rodriguez-Rodriguez, R. Start date: 02/09/2024 End date: 01/09/2026
    Financing entity: Agencia de Gestió d'ajudas Universitaries Investigació AGAUR Financing entity code: 2023 PROD 00094
  • Protein-based nanoparticles for nose-to-brain delivery to treat obesity. (Innovadors)
    PI: Rodriguez-Rodriguez, R. Start date: 02/09/2024 End date: 01/09/2026
    Financing entity: Agencia de Gestió d'ajudas Universitaries Investigació AGAUR Financing entity code: 2023 INNOV 00004
  • Multifunctional all-protein-based nanoparticles for nose-to-brain delivery
    PI: Rodriguez-Rodriguez, R. Start date: 05/09/2022 End date: 04/09/2023
    Financing entity: Agencia de Gestió d'ajudas Universitaries Investigació AGAUR Financing entity code: 2021 LLAV 00064
  • Drug delivery targeting Brain CPT1: a novel nanomedicine-based approach to fight obesity and cancer” (CONCORD)
    PI: Rodriguez-Rodriguez, R.; Quader, S. Start date: 09/09/2019 End date: 05/09/2022
    Financing entity: US Department of State and Ministry of Education and Science of Spain Financing entity code: PCI2018-092997
  • Regulation of Lipid Metabolism in Obesity and Diabetes (METALIP)
    PI: Serra, D. Start date: 04/09/2017 End date: 01/03/2021
    Financing entity: Agencia de Gestió d'ajudas Universitaries Investigació AGAUR Financing entity code: 2017SGR278
  • Modulación del metabolismo lipídico periférico y central para reducir la ingesta y la obesidad
    PI: Serra, D. Start date: 03/09/2018 End date: 07/09/2020
    Financing entity: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD Financing entity code: SAF2017-83813-C3-1-R
  • Carnitine palmitoyltransferase 1- mediated strategies to activate brown fat and reduce food intake to fight against obesity
    PI: Serra, D.; Herrero, L. Start date: 09/01/2017 End date: 14/01/2019
    Financing entity: Fundació la Marató de TV3 Financing entity code: 87/C/2016. Subprojecto-1 201627.30
  • Nanoscale, Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
    Name: Paraiso, W.; Palacin, C.; Zagmutt, S.; Quader, S.; Rodriguez, R. Role: Autor Publishing date: 2025
    Start page: 66 End page: 89 Vol.: 18
    DOI: 10.1039/D5NR02259B ISSN or title: 2040-3364
  • Reviews in endocrine and metabolic disorders, Early Hypothalamic microinflammation: The Hidden Trigger Behind Metabolic Diseases
    Name: Zagmutt, S.; Rodriguez, M.; Bolaños, M.; Reguera, AC.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2025
    ISSN or title: 1389-9155
  • Molecular Metabolism, CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity
    Name: Fosch, A.; Pizarro, D.; Zagmutt, S.; Reguera, AC.; Batallé, G.; Rodríguez, M.; García-Chica, J.; Freire-Agulleiro, O.; Miralpeix, C.; Zizzari, P.; Serra, D.; Herrero, L.; Lopez, M.; Cota, D.; Rodriguez-Rodriguez, R.; Casals, N Role: Autor Publishing date: 2025
    Vol.: 96
    DOI: 10.1016/j.molmet.2025.102155 ISSN or title: 2212-8778
  • Pharmacological reviews, International Union of Basic and Clinical Pharmacology: Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes
    Name: Rodriguez-Rodriguez, R.; Baena, M.; Zagmutt, S.; Paraiso, W.; Reguera, AC.; Fadó, R.; Casals, N Role: Autor Publishing date: 2025
    Vol.: 77 No.: 3
    DOI: 10.1016/j.pharmr.2025.100051 ISSN or title: 0031-6997
  • Nature communications, The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk
    Name: Valdecantos, M.; Ruiz, L.; Folgueira, C.; Rada, P.; Gomez-Santos, B.; Solas, M.; Hitos, A.; Field, J.; Vera, F.; Escalona-Garrido, C.; Zagmutt, S.; Calderon-Dominguez, M.; Mera, P.; Garcia-Martinez, I.; Maymó-Masip, E.; Grajales, D.; Alen, R.; Mora, A.; Sáinz, N.; Vides-Urrestarazu, I.; Vilarrasa, N.; Arbones-Mainar, J.; Zaragoza, C.; Moreno-Aliaga, M.; Aspichueta, P.; Fernández-Veledo, S.; Vendrell, J.; Serra, D.; Herrero, L.; Schreiber, R.; Zechner, R.; Sabio, G.; Hornigold, D.; Rondinone, C.; Jermutus, L.; Grimsby, J.; Valverde, Á. Role: Autor Publishing date: 2024
    Vol.: 15
    DOI: 10.1038/s41467-024-54080-w ISSN or title: 2041-1723
  • Aging Cell, Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice
    Name: Ibeas, K.; Griñán-Ferré, C.; del Mar Romero, M.; Sebastián , D.; Bastías-Pérez, M.; Gomez, R.; Soler-Vázquez, M.; Zagmutt, S.; Pallás, M.; Castell, M.; Belsham, D.; Mera, P.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2024
    Vol.: 23 No.: 2
    DOI: 10.1111/acel.14047 ISSN or title: 14749718
  • Biology of Sex Differences, CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
    Name: Zagmutt, S.; Mera, P.; González, I.; Ibeas, K.; Romero, M.; Obri, A.; Martin, B.; Esteve, A.; Soler-Vázquez, M.C.; Bastias, M.; Cañes, L.; Augé, E.; Pelegri, C.; Vilaplana, J.; Ariza, X.; García, J.; Martinez, J.; Casals, N; López, M.; Palmiter, R.; Sanz, E.; Quintana, A.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2023
    Vol.: 14 No.: 1
    DOI: 10.1186/s13293-023-00498-8 ISSN or title: 2042-6410
  • Metabolic engineering, Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice
    Name: Soler-Vázquez, M.C.; Romero, M.; Todorcevic, M.; Delgado, K.; Calatayud, C.; Benitez, A.; La Chica, M.; Mera, P.; Zagmutt, S.; Bastías, M.; Ibeas, K.; Casals, N; Escolà, J.; Llorente-Cortés, V.; Consiglio, A.; Serra, D.; Herrero, L. Role: Autor Publishing date: 2023
    Start page: 256 End page: 272 Vol.: 77
    DOI: 10.1016/j.ymben.2023.04.010 ISSN or title: 1096-7176
  • Nature Metabolism, Angiocrine polyamine production regulates adiposity
    Name: Monelli, E.; Villacampa, P.; Zabala-Letona; Martinez-Romero, A.; Llena, J.; Beiroa, D.; Gouveia, L.; Chivite, I.; Zagmutt, S.; Gama-Perez, P.; Osorio-Conles, O.; Muixi, L.; Martinez-Gonzalez, A.; Castillo, S.; Martín-Martín, N.; Castel, P.; Valcarcel-Jimenez, L.; Garcia-Gonzalez, I.; Villena, J.; Fernandez-Ruiz, S.; Serra, D.; Herrero, L.; Benedito, R.; Garcia-Roves, P.; Vidal, J.; Cohen, P.; Nogueiras, R.; Claret , M.; Carracedo, A.; Graupera, M. Role: Autor Publishing date: 2023
    Start page: 327 End page: 343 Vol.: 4 No.: 3
    DOI: 10.1038/s42255-022-00544-6 ISSN or title: 25225812
  • Biomaterials science, Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
    Name: Garcia, J.; Paraiso, W.; Zagmutt, S.; Fosch, A.; Reguera, AC.; Alzina, S.; Sánchez, L.; Fukushima, S.; Toh, K.; Casals, N; Serra, D.; Herrero, L.; Garcia, J.; Kataoka, K.; Ariza, X.; Quader, S.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2023
    Start page: 2336 End page: 2347 Vol.: 11
    DOI: 10.1039/d2bm01751b ISSN or title: 2047-4830
  • JOURNAL OF NEUROENDOCRINOLOGY, Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: A promising strategy to regulate energy balance
    Name: Rodriguez-Rodriguez, R.; Fosch, A.; Garcia, J.; Zagmutt, S.; Casals, N Role: Autor Publishing date: 2023
    Vol.: 35 No.: 9
    DOI: 10.1111/jne.13234 ISSN or title: 1365-2826
  • Cell death and disease, To be or not to be a fat burner, that is the question for cpt1c in cancer cells
    Name: Fadó, R.; Zagmutt, S.; Herrero, L.; Muley, H.; Rodriguez-Rodriguez, R.; Bi, H.; Serra, D.; Casals, N Role: Autor Publishing date: 2023
    Vol.: 14 No.: 1
    DOI: 10.1038/s41419-023-05599-1 ISSN or title: 2041-4889
  • International Journal of Molecular Sciences, Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids
    Name: Fosch, A.; Rodriguez, M.; Miralpeix, C.; Zagmutt, S.; Larrañaga, M.; Reguera, AC.; Garcia, J.; Herrero, L.; Serra, D.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2023
    Vol.: 24 No.: 2
    DOI: 10.3390/ijms24021697 ISSN or title: 1422-0067
  • Antioxidants, Integrated Metabolomics, Lipidomics, and Genomics Reveal the Presence of a New Biomarker, Butanediol Glucuronide, Associated with the Activation of Liver Ketogenesis and Lipid Oxidation by Tomato-Based Sofrito in Obese Rats
    Name: Rinaldi de Alvarenga, J.; Garcia, M.; Ulaszewska, M.; Zagmutt, S.; Perez-Montero, M.; Vrhovsek, U.; Lamuela Raventos, R.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2022
    Vol.: 11 No.: 11
    DOI: 10.3390/antiox11112165 ISSN or title: 2076-3921
  • Nutrients, Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic Acids in Obesity and Related Diseases
    Name: Claro-Cala, C.; Jiménez-Altayó, F.; Zagmutt, S.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2022
    Vol.: 14 No.: 8
    DOI: 10.3390/nu14081606 ISSN or title: 2072-6643
  • Cellular and molecular life sciences, Hypothalamic endocannabinoids in obesity: an old story with new challenges
    Name: Miralpeix, C.; Reguera, AC.; Fosch, A.; Zagmutt, S.; Casals, N; Cota, D.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2021
    Start page: 7469 End page: 7490 Vol.: 78 No.: 23
    DOI: 10.1007/s00018-021-04002-6 ISSN or title: 1420-682X
  • Biomaterials science, Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells
    Name: Paraiso, W.; Garcia, J.; Ariza, J.; Zagmutt, S.; Fukushima, S.; Garcia, J.; Mochida, Y.; Serra, D.; Herrero, L.; Kinoh, H.; Casals, N; Kataoka, K.; Rodriguez-Rodriguez, R.; Quader, S. Role: Autor Publishing date: 2021
    Start page: 7076 End page: 7091 Vol.: 9 No.: 21
    DOI: 10.1039/d1bm00689d ISSN or title: 2047-4830
  • International Journal of Molecular Sciences, New insights of sf1 neurons in hypothalamic regulation of obesity and diabetes
    Name: Fosch, A.; Zagmutt, S.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2021
    Vol.: 22 No.: 12
    DOI: 10.3390/ijms22126186 ISSN or title: 1422-0067
  • Molecular Metabolism, Moderate SIRT1 overexpression protects against brown adipose tissue inflammation
    Name: Escalona-Garrido, C.; Vázquez, P.; Mera, P.; Zagmutt, S.; García-Casarrubios, E.; Montero-Pedrazuela, A.; Rey-Stolle, F.; Guadaño-Ferraz, A.; Rupérez, F.; Serra, D.; Herrero, L.; Obregon, M.; Valverde, Á. Role: Autor Publishing date: 2020
    Vol.: 42
    DOI: 10.1016/j.molmet.2020.101097 ISSN or title: 2212-8778
  • Cells, Impact of adaptive thermogenesis in mice on the treatment of obesity
    Name: Bastías-Pérez, M.; Zagmutt, S.; Soler-Vázquez, M.; Serra, D.; Mera, P.; Herrero, L. Role: Autor Publishing date: 2020
    Vol.: 9 No.: 316
    DOI: 10.3390/cells9020316 ISSN or title: 20734409
  • BIOCHEMICAL PHARMACOLOGY, New approaches targeting brown adipose tissue transplantation as a therapy in obesity
    Name: Soler-Vázquez, M.; Mera, P.; Zagmutt, S.; Serra, D.; Herrero, L. Role: Autor Publishing date: 2018
    Start page: 346 End page: 355 Vol.: 155
    DOI: 10.1016/j.bcp.2018.07.022 ISSN or title: 1873-2968
  • BIOCHEMICAL PHARMACOLOGY, Targeting AgRP neurons to maintain energy balance: Lessons from animal models
    Name: Zagmutt, S.; Mera, P.; Soler-Vázquez, M.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2018
    Start page: 224 End page: 232 Vol.: 155
    DOI: 10.1016/j.bcp.2018.07.008 ISSN or title: 1873-2968
  • BIOCHEMICAL PHARMACOLOGY, New approaches targeting brown adipose tissue transplantation as a therapy in obesity
    Name: Soler-Vázquez, M.; Mera, P.; Zagmutt, S.; Serra, D.; Herrero, L. Role: Autor Publishing date: 2018
    Start page: 346 End page: 355 Vol.: 155
    DOI: 10.1016/j.bcp.2018.07.022 ISSN or title: 1873-2968
  • European journal of clinical investigation, Obesity-induced hepatic steatosis in mice is reverted by AAV9-mediated enhanced fatty-acid oxidation      
    Name: Serra, D.; Zagmutt, S.; Weber, M.; Casas, J.; Herrero, L. Role: Autor Publishing date: 2018
    Start page: 66 End page: 66
    ISSN or title: 0014-2972
  • Molecular neurobiology, Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex
    Name: Mir, J.; Zagmutt, S.; Lichtenstein, M.; Casals, N; Herrero, L.; Serra, D. Role: Autor Publishing date: 2018
    Start page: 7216 End page: 7228 Vol.: 55
    DOI: 10.1007/s12035-018-0921-3 ISSN or title: 0893-7648
  • Oxidative medicine and cellular longevity, High-Intensity Exercise Reduces Cardiac Fibrosis and Hypertrophy but Does Not Restore the Nitroso-Redox Imbalance in Diabetic Cardiomyopathy
    Name: Novoa, U.; Arauna, D.; Moran, M.; Nuñez, M.; Zagmutt, S.; Saldivia, S.; Valdes, C.; Villaseñor, J.; Zambrano, C.; Gonzalez, D. Role: Autor Publishing date: 2017
    Vol.: 2017
    DOI: 10.1155/2017/7921363 ISSN or title: 1942-0900
  • International journal of food properties, Phenolic Compound Identification and Antioxidant Capacity of Alperujo Extracts from Region del Maule, Chile
    Name: Zagmutt, S.; Guzmán, L.; Orrego, R.; Wehinger, S.; Leiva, E. Role: Autor Publishing date: 2016
    Vol.: 19 No.: 9
    DOI: 10.1080/10942912.2015.1092162 ISSN or title: 1094-2912
  • Journal of Food and Nutrition Research, Protective Effect of Propolis Extract on Pancreatic β Cell under Oxidative Stress in vitro
    Name: Zagmutt, S.; Guzmán, L.; Orrego, R.; Wehinger, S.; Leiva, E. Role: Autor Publishing date: 2016
    ISSN or title: 1336-8672
Course 2025-2026 - Period: 01/09/2025 - 31/08/2026
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Final Degree Project
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Cell Biology I
    • - External Laboratory Practices
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Practicum I
    • - Final Master's Degree Project
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum II
Course 2024-2025 - Period: 01/09/2024 - 31/08/2025
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Work Placement
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Final Master's Degree Project
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum I
    • - Practicum II
Course 2023-2024 - Period: 01/09/2023 - 31/08/2024
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Techniques for Biomedical Analysis I
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum II
    • - Final Master's Degree Project
    • - Practicum I
Course 2022-2023 - Period: 01/09/2022 - 31/08/2023
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Work Placement
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Techniques for Biomedical Analysis I
Course 2021-2022 - Period: 01/09/2021 - 31/08/2022
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis II
    • - Introduction to Biomedicine
    • - Techniques for Biomedical Analysis I
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Work Placement
Course 2020-2021 - Period: 01/09/2020 - 31/08/2021
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Introduction to Biomedicine
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II

Academic training

  • Tecnología Médica
  • Universidad de Talca
  • Master Ciencias Biomédicas
  • Universidad de Talca
  • Doctorado en Biotecnología
  • Universidad de Barcelona

Doctor in Biotechnology, UNIVERSITAT DE BARCELONA
Master in Biomedical Sciences: Clinical Biochemistry and Immunohematology, UNIVERSIDAD DE CHILE
Graduated Medical Technologist, UNIVERSIDAD DE CHILE
Graduate in Medical Technology, UNIVERSIDAD DE CHILE
Diploma in Competency-Based Higher Education, UNIVERSIDAD DE CHILE

Projects

Competitive

  • GerOMIC: Unveiling Biomarker-Based Strategies for Healthy Aging (Espera de Resolución)
    PI: Zagmutt, S.; Bosch, J. Start date: 05/01/2026 End date: 05/03/2029
    Financing entity: Universitat Internacional de Catalunya Financing entity code: Instituto de Salud Carlos III (ISCIII)
  • Proteínas CPT1 en el hipotálamo: Descifrando la percepción de grasas saturadas y no saturadas y sus implicaciones en el desarrollo de la obesidad
    PI: Casals, N; Rodriguez-Rodriguez, R. Start date: 01/09/2024 End date: 31/08/2027
    Financing entity: MINISTERIO DE CIENCIA E INNOVACION Financing entity code: PID2023-146716OB-I00
  • Response to an intervention with Omega-3 fatty acids on lipid and inflammatory profile in overweight and hypertriglyceridemic individuals in Valdivia, Chile. (RIO-study)
    PI: Sandoval, V. Start date: 08/01/2024 End date: 04/01/2027
    Financing entity: FONDECYT - Agencia Nacional de Investigación y Desarrollo del Ministerio de Ciencia, Tecnología, Conocimiento e Innovación de Chile Financing entity code: 11241108
  • Protein-based nanoparticles for nose-to-brain delivery to treat obesity (Producte)
    PI: Rodriguez-Rodriguez, R. Start date: 02/09/2024 End date: 01/09/2026
    Financing entity: Agencia de Gestió d'ajudas Universitaries Investigació AGAUR Financing entity code: 2023 PROD 00094
  • Protein-based nanoparticles for nose-to-brain delivery to treat obesity. (Innovadors)
    PI: Rodriguez-Rodriguez, R. Start date: 02/09/2024 End date: 01/09/2026
    Financing entity: Agencia de Gestió d'ajudas Universitaries Investigació AGAUR Financing entity code: 2023 INNOV 00004
  • Multifunctional all-protein-based nanoparticles for nose-to-brain delivery
    PI: Rodriguez-Rodriguez, R. Start date: 05/09/2022 End date: 04/09/2023
    Financing entity: Agencia de Gestió d'ajudas Universitaries Investigació AGAUR Financing entity code: 2021 LLAV 00064
  • Drug delivery targeting Brain CPT1: a novel nanomedicine-based approach to fight obesity and cancer” (CONCORD)
    PI: Rodriguez-Rodriguez, R.; Quader, S. Start date: 09/09/2019 End date: 05/09/2022
    Financing entity: US Department of State and Ministry of Education and Science of Spain Financing entity code: PCI2018-092997
  • Regulation of Lipid Metabolism in Obesity and Diabetes (METALIP)
    PI: Serra, D. Start date: 04/09/2017 End date: 01/03/2021
    Financing entity: Agencia de Gestió d'ajudas Universitaries Investigació AGAUR Financing entity code: 2017SGR278
  • Modulación del metabolismo lipídico periférico y central para reducir la ingesta y la obesidad
    PI: Serra, D. Start date: 03/09/2018 End date: 07/09/2020
    Financing entity: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD Financing entity code: SAF2017-83813-C3-1-R
  • Carnitine palmitoyltransferase 1- mediated strategies to activate brown fat and reduce food intake to fight against obesity
    PI: Serra, D.; Herrero, L. Start date: 09/01/2017 End date: 14/01/2019
    Financing entity: Fundació la Marató de TV3 Financing entity code: 87/C/2016. Subprojecto-1 201627.30

Publications

Articles

  • Nanoscale, Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
    Name: Paraiso, W.; Palacin, C.; Zagmutt, S.; Quader, S.; Rodriguez, R. Role: Autor Publishing date: 2025
    Start page: 66 End page: 89 Vol.: 18
    DOI: 10.1039/D5NR02259B ISSN or title: 2040-3364
  • Reviews in endocrine and metabolic disorders, Early Hypothalamic microinflammation: The Hidden Trigger Behind Metabolic Diseases
    Name: Zagmutt, S.; Rodriguez, M.; Bolaños, M.; Reguera, AC.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2025
    ISSN or title: 1389-9155
  • Molecular Metabolism, CPT1C deficiency in SF1 neurons impairs early metabolic adaptation to dietary fats, leading to obesity
    Name: Fosch, A.; Pizarro, D.; Zagmutt, S.; Reguera, AC.; Batallé, G.; Rodríguez, M.; García-Chica, J.; Freire-Agulleiro, O.; Miralpeix, C.; Zizzari, P.; Serra, D.; Herrero, L.; Lopez, M.; Cota, D.; Rodriguez-Rodriguez, R.; Casals, N Role: Autor Publishing date: 2025
    Vol.: 96
    DOI: 10.1016/j.molmet.2025.102155 ISSN or title: 2212-8778
  • Pharmacological reviews, International Union of Basic and Clinical Pharmacology: Fundamental insights and clinical relevance regarding the carnitine palmitoyltransferase family of enzymes
    Name: Rodriguez-Rodriguez, R.; Baena, M.; Zagmutt, S.; Paraiso, W.; Reguera, AC.; Fadó, R.; Casals, N Role: Autor Publishing date: 2025
    Vol.: 77 No.: 3
    DOI: 10.1016/j.pharmr.2025.100051 ISSN or title: 0031-6997
  • Nature communications, The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk
    Name: Valdecantos, M.; Ruiz, L.; Folgueira, C.; Rada, P.; Gomez-Santos, B.; Solas, M.; Hitos, A.; Field, J.; Vera, F.; Escalona-Garrido, C.; Zagmutt, S.; Calderon-Dominguez, M.; Mera, P.; Garcia-Martinez, I.; Maymó-Masip, E.; Grajales, D.; Alen, R.; Mora, A.; Sáinz, N.; Vides-Urrestarazu, I.; Vilarrasa, N.; Arbones-Mainar, J.; Zaragoza, C.; Moreno-Aliaga, M.; Aspichueta, P.; Fernández-Veledo, S.; Vendrell, J.; Serra, D.; Herrero, L.; Schreiber, R.; Zechner, R.; Sabio, G.; Hornigold, D.; Rondinone, C.; Jermutus, L.; Grimsby, J.; Valverde, Á. Role: Autor Publishing date: 2024
    Vol.: 15
    DOI: 10.1038/s41467-024-54080-w ISSN or title: 2041-1723
  • Aging Cell, Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice
    Name: Ibeas, K.; Griñán-Ferré, C.; del Mar Romero, M.; Sebastián , D.; Bastías-Pérez, M.; Gomez, R.; Soler-Vázquez, M.; Zagmutt, S.; Pallás, M.; Castell, M.; Belsham, D.; Mera, P.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2024
    Vol.: 23 No.: 2
    DOI: 10.1111/acel.14047 ISSN or title: 14749718
  • Biology of Sex Differences, CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
    Name: Zagmutt, S.; Mera, P.; González, I.; Ibeas, K.; Romero, M.; Obri, A.; Martin, B.; Esteve, A.; Soler-Vázquez, M.C.; Bastias, M.; Cañes, L.; Augé, E.; Pelegri, C.; Vilaplana, J.; Ariza, X.; García, J.; Martinez, J.; Casals, N; López, M.; Palmiter, R.; Sanz, E.; Quintana, A.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2023
    Vol.: 14 No.: 1
    DOI: 10.1186/s13293-023-00498-8 ISSN or title: 2042-6410
  • Metabolic engineering, Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice
    Name: Soler-Vázquez, M.C.; Romero, M.; Todorcevic, M.; Delgado, K.; Calatayud, C.; Benitez, A.; La Chica, M.; Mera, P.; Zagmutt, S.; Bastías, M.; Ibeas, K.; Casals, N; Escolà, J.; Llorente-Cortés, V.; Consiglio, A.; Serra, D.; Herrero, L. Role: Autor Publishing date: 2023
    Start page: 256 End page: 272 Vol.: 77
    DOI: 10.1016/j.ymben.2023.04.010 ISSN or title: 1096-7176
  • Nature Metabolism, Angiocrine polyamine production regulates adiposity
    Name: Monelli, E.; Villacampa, P.; Zabala-Letona; Martinez-Romero, A.; Llena, J.; Beiroa, D.; Gouveia, L.; Chivite, I.; Zagmutt, S.; Gama-Perez, P.; Osorio-Conles, O.; Muixi, L.; Martinez-Gonzalez, A.; Castillo, S.; Martín-Martín, N.; Castel, P.; Valcarcel-Jimenez, L.; Garcia-Gonzalez, I.; Villena, J.; Fernandez-Ruiz, S.; Serra, D.; Herrero, L.; Benedito, R.; Garcia-Roves, P.; Vidal, J.; Cohen, P.; Nogueiras, R.; Claret , M.; Carracedo, A.; Graupera, M. Role: Autor Publishing date: 2023
    Start page: 327 End page: 343 Vol.: 4 No.: 3
    DOI: 10.1038/s42255-022-00544-6 ISSN or title: 25225812
  • Biomaterials science, Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
    Name: Garcia, J.; Paraiso, W.; Zagmutt, S.; Fosch, A.; Reguera, AC.; Alzina, S.; Sánchez, L.; Fukushima, S.; Toh, K.; Casals, N; Serra, D.; Herrero, L.; Garcia, J.; Kataoka, K.; Ariza, X.; Quader, S.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2023
    Start page: 2336 End page: 2347 Vol.: 11
    DOI: 10.1039/d2bm01751b ISSN or title: 2047-4830
  • JOURNAL OF NEUROENDOCRINOLOGY, Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: A promising strategy to regulate energy balance
    Name: Rodriguez-Rodriguez, R.; Fosch, A.; Garcia, J.; Zagmutt, S.; Casals, N Role: Autor Publishing date: 2023
    Vol.: 35 No.: 9
    DOI: 10.1111/jne.13234 ISSN or title: 1365-2826
  • Cell death and disease, To be or not to be a fat burner, that is the question for cpt1c in cancer cells
    Name: Fadó, R.; Zagmutt, S.; Herrero, L.; Muley, H.; Rodriguez-Rodriguez, R.; Bi, H.; Serra, D.; Casals, N Role: Autor Publishing date: 2023
    Vol.: 14 No.: 1
    DOI: 10.1038/s41419-023-05599-1 ISSN or title: 2041-4889
  • International Journal of Molecular Sciences, Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids
    Name: Fosch, A.; Rodriguez, M.; Miralpeix, C.; Zagmutt, S.; Larrañaga, M.; Reguera, AC.; Garcia, J.; Herrero, L.; Serra, D.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2023
    Vol.: 24 No.: 2
    DOI: 10.3390/ijms24021697 ISSN or title: 1422-0067
  • Antioxidants, Integrated Metabolomics, Lipidomics, and Genomics Reveal the Presence of a New Biomarker, Butanediol Glucuronide, Associated with the Activation of Liver Ketogenesis and Lipid Oxidation by Tomato-Based Sofrito in Obese Rats
    Name: Rinaldi de Alvarenga, J.; Garcia, M.; Ulaszewska, M.; Zagmutt, S.; Perez-Montero, M.; Vrhovsek, U.; Lamuela Raventos, R.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2022
    Vol.: 11 No.: 11
    DOI: 10.3390/antiox11112165 ISSN or title: 2076-3921
  • Nutrients, Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic Acids in Obesity and Related Diseases
    Name: Claro-Cala, C.; Jiménez-Altayó, F.; Zagmutt, S.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2022
    Vol.: 14 No.: 8
    DOI: 10.3390/nu14081606 ISSN or title: 2072-6643
  • Cellular and molecular life sciences, Hypothalamic endocannabinoids in obesity: an old story with new challenges
    Name: Miralpeix, C.; Reguera, AC.; Fosch, A.; Zagmutt, S.; Casals, N; Cota, D.; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2021
    Start page: 7469 End page: 7490 Vol.: 78 No.: 23
    DOI: 10.1007/s00018-021-04002-6 ISSN or title: 1420-682X
  • Biomaterials science, Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells
    Name: Paraiso, W.; Garcia, J.; Ariza, J.; Zagmutt, S.; Fukushima, S.; Garcia, J.; Mochida, Y.; Serra, D.; Herrero, L.; Kinoh, H.; Casals, N; Kataoka, K.; Rodriguez-Rodriguez, R.; Quader, S. Role: Autor Publishing date: 2021
    Start page: 7076 End page: 7091 Vol.: 9 No.: 21
    DOI: 10.1039/d1bm00689d ISSN or title: 2047-4830
  • International Journal of Molecular Sciences, New insights of sf1 neurons in hypothalamic regulation of obesity and diabetes
    Name: Fosch, A.; Zagmutt, S.; Casals, N; Rodriguez-Rodriguez, R. Role: Autor Publishing date: 2021
    Vol.: 22 No.: 12
    DOI: 10.3390/ijms22126186 ISSN or title: 1422-0067
  • Molecular Metabolism, Moderate SIRT1 overexpression protects against brown adipose tissue inflammation
    Name: Escalona-Garrido, C.; Vázquez, P.; Mera, P.; Zagmutt, S.; García-Casarrubios, E.; Montero-Pedrazuela, A.; Rey-Stolle, F.; Guadaño-Ferraz, A.; Rupérez, F.; Serra, D.; Herrero, L.; Obregon, M.; Valverde, Á. Role: Autor Publishing date: 2020
    Vol.: 42
    DOI: 10.1016/j.molmet.2020.101097 ISSN or title: 2212-8778
  • Cells, Impact of adaptive thermogenesis in mice on the treatment of obesity
    Name: Bastías-Pérez, M.; Zagmutt, S.; Soler-Vázquez, M.; Serra, D.; Mera, P.; Herrero, L. Role: Autor Publishing date: 2020
    Vol.: 9 No.: 316
    DOI: 10.3390/cells9020316 ISSN or title: 20734409
  • BIOCHEMICAL PHARMACOLOGY, New approaches targeting brown adipose tissue transplantation as a therapy in obesity
    Name: Soler-Vázquez, M.; Mera, P.; Zagmutt, S.; Serra, D.; Herrero, L. Role: Autor Publishing date: 2018
    Start page: 346 End page: 355 Vol.: 155
    DOI: 10.1016/j.bcp.2018.07.022 ISSN or title: 1873-2968
  • BIOCHEMICAL PHARMACOLOGY, Targeting AgRP neurons to maintain energy balance: Lessons from animal models
    Name: Zagmutt, S.; Mera, P.; Soler-Vázquez, M.; Herrero, L.; Serra, D. Role: Autor Publishing date: 2018
    Start page: 224 End page: 232 Vol.: 155
    DOI: 10.1016/j.bcp.2018.07.008 ISSN or title: 1873-2968
  • BIOCHEMICAL PHARMACOLOGY, New approaches targeting brown adipose tissue transplantation as a therapy in obesity
    Name: Soler-Vázquez, M.; Mera, P.; Zagmutt, S.; Serra, D.; Herrero, L. Role: Autor Publishing date: 2018
    Start page: 346 End page: 355 Vol.: 155
    DOI: 10.1016/j.bcp.2018.07.022 ISSN or title: 1873-2968
  • European journal of clinical investigation, Obesity-induced hepatic steatosis in mice is reverted by AAV9-mediated enhanced fatty-acid oxidation      
    Name: Serra, D.; Zagmutt, S.; Weber, M.; Casas, J.; Herrero, L. Role: Autor Publishing date: 2018
    Start page: 66 End page: 66
    ISSN or title: 0014-2972
  • Molecular neurobiology, Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex
    Name: Mir, J.; Zagmutt, S.; Lichtenstein, M.; Casals, N; Herrero, L.; Serra, D. Role: Autor Publishing date: 2018
    Start page: 7216 End page: 7228 Vol.: 55
    DOI: 10.1007/s12035-018-0921-3 ISSN or title: 0893-7648
  • Oxidative medicine and cellular longevity, High-Intensity Exercise Reduces Cardiac Fibrosis and Hypertrophy but Does Not Restore the Nitroso-Redox Imbalance in Diabetic Cardiomyopathy
    Name: Novoa, U.; Arauna, D.; Moran, M.; Nuñez, M.; Zagmutt, S.; Saldivia, S.; Valdes, C.; Villaseñor, J.; Zambrano, C.; Gonzalez, D. Role: Autor Publishing date: 2017
    Vol.: 2017
    DOI: 10.1155/2017/7921363 ISSN or title: 1942-0900
  • International journal of food properties, Phenolic Compound Identification and Antioxidant Capacity of Alperujo Extracts from Region del Maule, Chile
    Name: Zagmutt, S.; Guzmán, L.; Orrego, R.; Wehinger, S.; Leiva, E. Role: Autor Publishing date: 2016
    Vol.: 19 No.: 9
    DOI: 10.1080/10942912.2015.1092162 ISSN or title: 1094-2912
  • Journal of Food and Nutrition Research, Protective Effect of Propolis Extract on Pancreatic β Cell under Oxidative Stress in vitro
    Name: Zagmutt, S.; Guzmán, L.; Orrego, R.; Wehinger, S.; Leiva, E. Role: Autor Publishing date: 2016
    ISSN or title: 1336-8672
Course 2025-2026 - Period: 01/09/2025 - 31/08/2026
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Final Degree Project
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Cell Biology I
    • - External Laboratory Practices
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Practicum I
    • - Final Master's Degree Project
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum II
Course 2024-2025 - Period: 01/09/2024 - 31/08/2025
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Work Placement
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Final Master's Degree Project
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum I
    • - Practicum II
Course 2023-2024 - Period: 01/09/2023 - 31/08/2024
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Techniques for Biomedical Analysis I
  • Official Master
    University Master's Degree in Experimental Biomedical Research
    • - Experimental Models in Biomedical Research
    • - Advanced Methodologies in Experimental Research and Data Analysis
    • - Practicum II
    • - Final Master's Degree Project
    • - Practicum I
Course 2022-2023 - Period: 01/09/2022 - 31/08/2023
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Work Placement
    • - Techniques for Biomedical Analysis II
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Techniques for Biomedical Analysis I
Course 2021-2022 - Period: 01/09/2021 - 31/08/2022
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Techniques for Biomedical Analysis II
    • - Introduction to Biomedicine
    • - Techniques for Biomedical Analysis I
    • - Cellular and Molecular Pathology
    • - Final Degree Project
    • - Work Placement
Course 2020-2021 - Period: 01/09/2020 - 31/08/2021
  • Bachelor’s Degree
    Bachelor's Degree in Biomedical Sciences
    • - Introduction to Biomedicine
    • - Techniques for Biomedical Analysis I
    • - Techniques for Biomedical Analysis II