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BOSCH PITA, Miguel

BOSCH PITA, Miguel

Professor Agregat
Faculty of Medicine and Health Sciences
Department of Biomedical Sciences

Contact

Tel. +34 932 541 800
Ext. 5214
miquelbosch@uic.es
ORCID
  • Academic training
  • Professional experience
  • Research lines
  • Publications
    • Articles
    • Book chapters
  • Subjects taught
  • Bioquímica
  • Universitat de Barcelona
  • Neurociències
  • Universitat de Barcelona
- Current positions: Assistant Professor (UIC-Barcelona, since September 2020); Group Leader of the Synaptic Plasticity Laboratory (since January 2021) Associate researcher (INc-UAB, since January 2022).
- Associate researcher, laboratory of M.V. Sánchez-Vives, Systems Neuroscience, Biomedical “Agustí Pi i Sunyer” Research Institute (IDIBAPS), Barcelona, Spain (May 2018-January 2021).
- MSCA researcher, Pau Gorostiza laboratory, Nanoprobes and Nanoswitches Lab, Institute of Bioengineering of Catalonia (IBEC), Barcelona, Spain (March 2015-April 2018).
- Research Scientist, Mark F. Bear Laboratory, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (May 2012-September 2014).
- Visiting research scientist, Yasunori Hayashi laboratory, Brain Science Institute (BSI), RIKEN, Wako, Japan (short stays: September-December 2010 and January-April 2012).
- FRAXA Postdoctoral Fellowship, Mark F. Bear Lab, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (August 2009-April 2012).
- “Beatriu de Pinós” Postdoctoral Fellowship, Yasunori Hayashi laboratory, RIKEN-MIT Neuroscience Research Center, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (from 2005-July 2009).
- Postdoctoral Associate, Tetsuo Yamamori laboratory, Division of Brain Biology, National. Institute of Basic Biology (NIBB), Okazaki, Japan (May-November 2005).
- Doctor. in Neuroscience. Department of Cell Biology and Pathological Anatomy, Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain (August 2000-April 19, 2005). Supervisors: Jordi Alberch and Josep M. Canals. Thesis title: Cell therapy in Huntington's disease models.
- Predoctoral internship, laboratory of Ernest Arenas, Biochemistry and Medical Biophysics Department, Karolinska Institute (KI), Stockholm, Sweden (August-November 2002).
- BS in Biochemistry. Faculty of Biology, Faculty of Chemistry, University of Barcelona (UB), Barcelona, Spain (February 2000).
- Degree Practices:
1) Antonio Zorzano Laboratory, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain (April-June 2000);
2) Jordi Bernués Laboratory, Department of Cellular and Molecular Biology, Institute of Molecular Biology of Barcelona (IBMB), CSIC, Spain (October 1999 – February 2000);
3) Marta Cascante Laboratory, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain (July-August 1997; July-August 1998).
Estic interessat en els mecanismes moleculars de l'aprenentatge i la memòria, i en evitar el seu deteriorament en malalties neurodegeneratives i psiquiàtriques. La meva recerca pretén entendre com s'emmagatzema la informació al sistema nerviós, des de la sinapsi individual fins a la xarxa neuronal. Un aspecte clau de la meva recerca és l'ús de tecnologies avançades basades en la llum, com ara la microscòpia multifotònica, l'optogenètica i la fotofarmacologia. Desenvolupo nous mètodes i aplicacions d'aquestes tecnologies per visualitzar i manipular, en temps real, els esdeveniments de plasticitat neuronal a múltiples nivells: circuits (per exemple, ones cerebrals), neurones (per exemple, mapes sinàptics en 4D), i sinapsis individuals (per exemple, potenciació i depressió a llarg termini). A més aplico aquests mètodes per desenvolupar fototeràpies basades en fotofarmacologia per a malalties com els trastorns de l'espectre autista, l'Alzheimer i l'epilèpsia.
  • PNAS Nexus, Control of cortical slow oscillations and epileptiform discharges with photoswitchable type 1 muscarinic ligands
    Name: Sanchez-Sanchez, Jose M.; Riefolo, Fabio; Barbero-Castillo, Almudena; Sortino, Rosalba; Agnetta, Luca; Manasanch, Arnau; Matera, Carlo; Bosch, Miquel; Forcella, Marta; Decker, Michael; Gorostiza, Pau; Sanchez-Vives, Maria V. Role: Autor Publishing date: 2025
    Vol.: 4 No.: 2
    DOI: 10.1093/pnasnexus/pgaf009
  • Progress in Neurobiology, Spatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro
    Name: Covelo, Joana; Camassa, Alessandra; Sanchez-Sanchez, Jose Manuel; Manasanch, Arnau; Porta, Leonardo Dalla; Cancino-Fuentes, Nathalia; Barbero-Castillo, Almudena; Robles, Rita M.; Bosch, Miquel; Tapia-Gonzalez, Silvia; Merino-Serrais, Paula; Carreño, Mar; Conde-Blanco, Estefania; Arboix, Jordi Rumià; Roldán, Pedro; DeFelipe, Javier; Sanchez-Vives, Maria V. Role: Autor Publishing date: 2025
    Vol.: 246
    DOI: 10.1016/j.pneurobio.2025.102719 ISSN or title: 0301-0082
  • Brain Stimulation, Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo
    Name: Garrido-Charles, Aida; Bosch, Miquel; Lee, Hyojung; Rovira, Xavier; Pittolo, Silvia; Llobet, Artur; Wong, Hovy Ho Wai; Trapero, Ana; Matera, Carlo; Papotto, Claudio; Serra, Carme; Llebaria, Amadeu; Soriano, Eduardo; Sanchez-Vives, Maria V.; Holt, Christine E.; Gorostiza, Pau Role: Autor Publishing date: 2025
    Start page: 1779 End page: 1793 Vol.: 18 No.: 6
    DOI: 10.1016/j.brs.2025.09.005 ISSN or title: 1935-861X
  • Nanoscale Horizons, Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states
    Name: Camassa, A.; Barbero-Castillo, A.; Bosch, M.; Dasilva, M.; Masvidal-Codina, E.; Villa, R.; Guimerà-Brunet, A.; Sanchez-Vives, M. V. Role: Autor Publishing date: 2024
    Start page: 589 End page: 597 Vol.: 9 No.: 4
    DOI: 10.1039/d3nh00440f ISSN or title: 2055-6756
  • Cerebral cortex, Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
    Name: Ortega-Gasco, Alba; Parcerisas, Antoni; Hino, Keiko; Herranz-Perez, Vicente; Ulloa, Fausto; Elias-Tersa, Alba; Bosch, Miquel; Garcia-Verdugo, Jose Manuel; Simo, Sergi; Pujadas, Lluis; Soriano, Eduardo Role: Autor Publishing date: 2023
    Start page: 10931 End page: 10948 Vol.: 33 No.: 21
    DOI: 10.1093/cercor/bhad340 ISSN or title: 1047-3211
  • bioRxiv, Regulation of adult neurogenesis and neuronal differentiation by Neural Cell Adhesion Molecule 2 (NCAM2)
    Name: Ortega-Gascó, A.; Parcerisas Mosqueda, Antoni; Hino, K.; Herranz, V.; Ulloa, F.; Elias, A.; Bosch Pita, Miguel; García, J.; Simó, S.; Pujadas, L.; Soriano, E. Role: Autor Publishing date: 2022
    DOI: 10.1101/2022.02.03.478938
  • Science Signaling, The elongation factor eEF1A2 controls translation and actin dynamics in dendritic spines
    Name: Mendoza, Mònica B.; Gutierrez, Sara; Ortiz, Raúl; Moreno, David F.; Dermit, Maria; Dodel, Martin; Rebollo, Elena; Bosch, Miquel; Mardakheh, Faraz K.; Gallego, Carme Role: Autor Publishing date: 2021
    Vol.: 14 No.: 691
    DOI: 10.1126/SCISIGNAL.ABF5594 ISSN or title: 1945-0877
  • Molecular psychiatry, Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice
    Name: Thomazeau, Aurore; Bosch, Miquel; Essayan-Perez, Sofia; Barnes, Stephanie A.; De Jesus-Cortes, Hector; Bear, Mark F. Role: Autor Publishing date: 2021
    Start page: 4652 End page: 4669 Vol.: 26 No.: 9
    DOI: 10.1038/s41380-020-0821-6 ISSN or title: 1359-4184
  • International Journal of Molecular Sciences, New partners identified by mass spectrometry assay reveal functions of NCAM2 in neural cytoskeleton organization
    Name: Parcerisas, Antoni; Ortega‐gascó, Alba; Hernaiz‐llorens, Marc; Odena, Maria Antonia; Ulloa, Fausto; de Oliveira, Eliandre; Bosch, Miquel; Pujadas, Lluís; Soriano, Eduardo Role: Autor Publishing date: 2021
    Vol.: 22 No.: 14
    DOI: 10.3390/ijms22147404 ISSN or title: 1661-6596
  • Cell Chemical Biology, Photocontrol of Endogenous Glycine Receptors In Vivo
    Name: Gomila, Alexandre M.J.; Rustler, Karin; Maleeva, Galyna; Nin-Hill, Alba; Wutz, Daniel; Bautista-Barrufet, Antoni; Rovira, Xavier; Bosch, Miquel; Mukhametova, Elvira; Petukhova, Elena; Ponomareva, Daria; Mukhamedyarov, Marat; Peiretti, Franck; Alfonso-Prieto, Mercedes; Rovira, Carme; König, Burkhard; Bregestovski, Piotr; Gorostiza, Pau Role: Autor Publishing date: 2020
    Start page: 1425 End page: 1433.e7 Vol.: 27 No.: 11
    DOI: 10.1016/j.chembiol.2020.08.005 ISSN or title: 2451-9456
  • Nature Communications , Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation
    Name: Cabré, Gisela; Garrido-Charles, Aida; Moreno, Miquel; Bosch, Miquel; Porta-de-la-Riva, Montserrat; Krieg, Michael; Gascón-Moya, Marta; Camarero, Núria; Gelabert, Ricard; Lluch, José M.; Busqué, Félix; Hernando, Jordi; Gorostiza, Pau; Alibés, Ramon Role: Autor Publishing date: 2019
    Vol.: 10 No.: 1
    DOI: 10.1038/s41467-019-08796-9
  • Proceedings of the National Academy of Sciences of the United States of America, Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology
    Name: Pittolo, Silvia; Lee, Hyojung; Lladó, Anna; Tosi, Sébastien; Bosch, Miquel; Bardia, Lídia; Gómez-Santacana, Xavier; Llebaria, Amadeu; Soriano, Eduardo; Colombelli, Julien; Poskanzer, Kira E.; Perea, Gertrudis; Gorostiza, Pau Role: Autor Publishing date: 2019
    Start page: 13680 End page: 13689 Vol.: 116 No.: 27
    DOI: 10.1073/pnas.1900430116 ISSN or title: 0027-8424
  • Neuron, Structural and molecular remodeling of dendritic spine substructures during long-term potentiation
    Name: Bosch, Miquel; Castro, Jorge; Saneyoshi, Takeo; Matsuno, Hitomi; Sur, Mriganka; Hayashi, Yasunori Role: Autor Publishing date: 2014
    Start page: 444 End page: 459 Vol.: 82 No.: 2
    DOI: 10.1016/j.neuron.2014.03.021 ISSN or title: 0896-6273
  • Metallomics, Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc
    Name: Huang, Zhen; Zhang, Xiao An; Bosch, Miquel; Smith, Sarah J.; Lippard, Stephen J. Role: Autor Publishing date: 2013
    Start page: 648 End page: 655 Vol.: 5 No.: 6
    DOI: 10.1039/c3mt00103b ISSN or title: 1756-5901
  • PLoS ONE, Multisensory information facilitates reaction speed by enlarging activity difference between superior colliculus hemispheres in rats
    Name: Hirokawa, Junya; Sadakane, Osamu; Sakata, Shuzo; Bosch, Miquel; Sakurai, Yoshio; Yamamori, Tetsuo Role: Autor Publishing date: 2011
    Vol.: 6 No.: 9
    DOI: 10.1371/journal.pone.0025283
  • Physiology, The roles of CaMKII and F-Actin in the structural plasticity of dendritic Spines
    Name: Okamoto, Kenichi; Bosch, Miquel; Hayashi, Yasunori Role: Autor Publishing date: 2009
    Start page: 357 End page: 366 Vol.: 24 No.: 6
    DOI: 10.1152/physiol.00029.2009 ISSN or title: 1548-9213
  • Neuroscience, Functional role of the secondary visual cortex in multisensory facilitation in rats
    Name: Hirokawa, J.; Bosch, M.; Sakata, S.; Sakurai, Y.; Yamamori, T. Role: Autor Publishing date: 2008
    Start page: 1402 End page: 1417 Vol.: 153 No.: 4
    DOI: 10.1016/j.neuroscience.2008.01.011 ISSN or title: 0306-4522
  • European Journal of Neuroscience, Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain
    Name: Ginés, Silvia; Bosch, Miquel; Marco, Sonia; Gavaldà, Núria; Díaz-Hernández, Miguel; Lucas, José J.; Canals, Josep M.; Alberch, Jordi Role: Autor Publishing date: 2006
    Start page: 649 End page: 658 Vol.: 23 No.: 3
    DOI: 10.1111/j.1460-9568.2006.04590.x ISSN or title: 0953-816X
  • Journal of neurochemistry, Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    Name: Pineda, José R.; Canals, Josep M.; Bosch, Miquel; Adell, Albert; Mengod, Guadalupe; Artigas, Francesc; Ernfors, Patrik; Alberch, Jordi Role: Autor Publishing date: 2005
    Start page: 1057 End page: 1068 Vol.: 93 No.: 5
    DOI: 10.1111/j.1471-4159.2005.03047.x ISSN or title: 0022-3042
  • Molecular therapy, Long-term expression of erythropoietin from myoblasts immobilized in biocompatible and neovascularized microcapsules
    Name: Orive, G.; De Castro, M.; Ponce, S.; Hernández, R. M.; Gascón, A. R.; Bosch, M.; Alberch, J.; Pedraz, José L. Role: Autor Publishing date: 2005
    Start page: 283 End page: 289 Vol.: 12 No.: 2
    DOI: 10.1016/j.ymthe.2005.04.002 ISSN or title: 1525-0016
  • Experimental Neurology, Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease
    Name: Bosch, Miquel; Pineda, José R.; Suñol, Cristina; Petriz, Jordi; Cattaneo, Elena; Alberch, Jordi; Canals, Josep M. Role: Autor Publishing date: 2004
    Start page: 42 End page: 58 Vol.: 190 No.: 1
    DOI: 10.1016/j.expneurol.2004.06.027 ISSN or title: 0014-4886
  • Journal of neuroscience, Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease
    Name: Canals, Josep M.; Pineda, José R.; Torres-Peraza, Jesus F.; Bosch, Miquel; Martín-Ibañez, Raquel; Muñoz, M. Teresa; Mengod, Guadalupe; Ernfors, Patrik; Alberch, Jordi Role: Autor Publishing date: 2004
    Start page: 7727 End page: 7739 Vol.: 24 No.: 35
    DOI: 10.1523/JNEUROSCI.1197-04.2004 ISSN or title: 0270-6474
  • Photomarking Relocalization Technique for Correlated Two-Photon and Electron Microscopy Imaging of Single Stimulated Synapses. Methods in Molecular Biology
    Name: Bosch, Miquel; Castro, Jorge; Sur, Mriganka; Hayashi, Yasunori Role: Autor Publishing date: 2025
    Start page: 145 End page: 175
  • Molecular mechanisms underlying synaptic tagging and consolidation. Synaptic tagging and capture
    Name: Hayashi, Y.; Bosch Pita, Miguel; Hosokawa, T.; Liu, P.; Saneyoshi, T. Role: Autor Publishing date: 2024
  • Molecular mechanisms underlying synaptic tagging and consolidation. Synaptic Tagging and Capture
    Name: Hayashi, Yasunori; Bosch, Miquel; Liu, Pin Wu; Hosokawa, Tomohisa; Saneyoshi, Takeo Role: Autor Publishing date: 2024
    Start page: 63 End page: 76
    ISBN: 9783031548635
  • Photomarking relocalization technique for correlated two-photon and electron microcopy imaging of single stimulated synapses. Methods in Molecular Biology
    Name: Bosch, Miquel; Castro, Jorge; Sur, Mriganka; Hayashi, Yasunori Role: Autor Publishing date: 2017
    Start page: 185 End page: 214
  • Photomarking Relocalization Technique for Correlated Two-Photon and Electron Microcopy Imaging of Single Stimulated Synapses. Synapse Development: Methods in Molecular Biology.
    Name: Bosch Pita, Miguel Role: Autor Publishing date: 2016
    Start page: 185 End page: 214
    ISBN: 978-1-4939-6688-2
  • Roles of neuronal activity-induced gene products in hebbian and homeostatic synaptic plasticity, tagging, and capture. Synaptic Plasticity
    Name: Hayashi, Yasunori; Okamoto, Ken Ichi; Bosch, Miquel; Futai, Kensuke Role: Autor Publishing date: 2012
    Start page: 335 End page: 354
    ISBN: 9783709109311
Course 2026-2027 - Period: 01/09/2026 - 31/08/2027
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Neuroscience Applied to Orthoprosthesis
    • - Cell and Molecular Biology
    Bachelor's Degree in Biomedical Sciences
    • - Final Degree Project
    • - Physiopathology of the Nervous System
    • - External Laboratory Practices
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Cell Biology I
    • - Cell Biology II
Course 2025-2026 - Period: 01/09/2025 - 31/08/2026
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    • - Neuroscience Applied to Orthoprosthesis
    Bachelor's Degree in Biomedical Sciences
    • - Final Degree Project
    • - Cell Biology I
    • - Physiopathology of the Nervous System
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Cell Biology II
    • - External Laboratory Practices
    Bachelor's Degree in Humanities and Cultural Studies
    • - Theory of Knowledge
Course 2024-2025 - Period: 01/09/2024 - 31/08/2025
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    • - Neuroscience Applied to Orthoprosthesis
    Bachelor's Degree in Biomedical Sciences
    • - Cell Biology II
    • - Cell Biology I
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Physiopathology of the Nervous System
    Bachelor's Degree in Humanities and Cultural Studies
    • - Theory of Knowledge
Course 2023-2024 - Period: 01/09/2023 - 31/08/2024
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    Bachelor's Degree in Biomedical Sciences
    • - Work Placement
    • - Cell Biology I
    • - Cell Biology II
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Physiopathology of the Nervous System
    • - Final Degree Project
Course 2022-2023 - Period: 01/09/2022 - 31/08/2023
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    • - In-Company Training
    • - Final Degree Project
    Bachelor's Degree in Biomedical Sciences
    • - Work Placement
    • - Cell Biology II
    • - Cell Biology I
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Final Degree Project
    • - Physiopathology of the Nervous System
Course 2021-2022 - Period: 01/09/2021 - 31/08/2022
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    Bachelor's Degree in Biomedical Sciences
    • - Cell Biology II
    • - Cell Biology I
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Final Degree Project
    • - Work Placement
    • - Physiopathology of the Nervous System
Course 2020-2021 - Period: 01/09/2020 - 31/08/2021
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    Bachelor's Degree in Biomedical Sciences
    • - Cell Biology I
    • - Molecular Biology
    • - Cell Biology II
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Physiopathology of the Nervous System
Course 2019-2020 - Period: 01/09/2019 - 31/08/2020
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    Bachelor's Degree in Medicine
    • - Cell Biology

Academic training

  • Bioquímica
  • Universitat de Barcelona
  • Neurociències
  • Universitat de Barcelona

Professional experience

- Current positions: Assistant Professor (UIC-Barcelona, since September 2020); Group Leader of the Synaptic Plasticity Laboratory (since January 2021) Associate researcher (INc-UAB, since January 2022).
- Associate researcher, laboratory of M.V. Sánchez-Vives, Systems Neuroscience, Biomedical “Agustí Pi i Sunyer” Research Institute (IDIBAPS), Barcelona, Spain (May 2018-January 2021).
- MSCA researcher, Pau Gorostiza laboratory, Nanoprobes and Nanoswitches Lab, Institute of Bioengineering of Catalonia (IBEC), Barcelona, Spain (March 2015-April 2018).
- Research Scientist, Mark F. Bear Laboratory, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (May 2012-September 2014).
- Visiting research scientist, Yasunori Hayashi laboratory, Brain Science Institute (BSI), RIKEN, Wako, Japan (short stays: September-December 2010 and January-April 2012).
- FRAXA Postdoctoral Fellowship, Mark F. Bear Lab, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (August 2009-April 2012).
- “Beatriu de Pinós” Postdoctoral Fellowship, Yasunori Hayashi laboratory, RIKEN-MIT Neuroscience Research Center, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (from 2005-July 2009).
- Postdoctoral Associate, Tetsuo Yamamori laboratory, Division of Brain Biology, National. Institute of Basic Biology (NIBB), Okazaki, Japan (May-November 2005).
- Doctor. in Neuroscience. Department of Cell Biology and Pathological Anatomy, Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain (August 2000-April 19, 2005). Supervisors: Jordi Alberch and Josep M. Canals. Thesis title: Cell therapy in Huntington's disease models.
- Predoctoral internship, laboratory of Ernest Arenas, Biochemistry and Medical Biophysics Department, Karolinska Institute (KI), Stockholm, Sweden (August-November 2002).
- BS in Biochemistry. Faculty of Biology, Faculty of Chemistry, University of Barcelona (UB), Barcelona, Spain (February 2000).
- Degree Practices:
1) Antonio Zorzano Laboratory, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain (April-June 2000);
2) Jordi Bernués Laboratory, Department of Cellular and Molecular Biology, Institute of Molecular Biology of Barcelona (IBMB), CSIC, Spain (October 1999 – February 2000);
3) Marta Cascante Laboratory, Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain (July-August 1997; July-August 1998).

Research lines

Estic interessat en els mecanismes moleculars de l'aprenentatge i la memòria, i en evitar el seu deteriorament en malalties neurodegeneratives i psiquiàtriques. La meva recerca pretén entendre com s'emmagatzema la informació al sistema nerviós, des de la sinapsi individual fins a la xarxa neuronal. Un aspecte clau de la meva recerca és l'ús de tecnologies avançades basades en la llum, com ara la microscòpia multifotònica, l'optogenètica i la fotofarmacologia. Desenvolupo nous mètodes i aplicacions d'aquestes tecnologies per visualitzar i manipular, en temps real, els esdeveniments de plasticitat neuronal a múltiples nivells: circuits (per exemple, ones cerebrals), neurones (per exemple, mapes sinàptics en 4D), i sinapsis individuals (per exemple, potenciació i depressió a llarg termini). A més aplico aquests mètodes per desenvolupar fototeràpies basades en fotofarmacologia per a malalties com els trastorns de l'espectre autista, l'Alzheimer i l'epilèpsia.

Publications

Articles

Book chapters

  • PNAS Nexus, Control of cortical slow oscillations and epileptiform discharges with photoswitchable type 1 muscarinic ligands
    Name: Sanchez-Sanchez, Jose M.; Riefolo, Fabio; Barbero-Castillo, Almudena; Sortino, Rosalba; Agnetta, Luca; Manasanch, Arnau; Matera, Carlo; Bosch, Miquel; Forcella, Marta; Decker, Michael; Gorostiza, Pau; Sanchez-Vives, Maria V. Role: Autor Publishing date: 2025
    Vol.: 4 No.: 2
    DOI: 10.1093/pnasnexus/pgaf009
  • Progress in Neurobiology, Spatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro
    Name: Covelo, Joana; Camassa, Alessandra; Sanchez-Sanchez, Jose Manuel; Manasanch, Arnau; Porta, Leonardo Dalla; Cancino-Fuentes, Nathalia; Barbero-Castillo, Almudena; Robles, Rita M.; Bosch, Miquel; Tapia-Gonzalez, Silvia; Merino-Serrais, Paula; Carreño, Mar; Conde-Blanco, Estefania; Arboix, Jordi Rumià; Roldán, Pedro; DeFelipe, Javier; Sanchez-Vives, Maria V. Role: Autor Publishing date: 2025
    Vol.: 246
    DOI: 10.1016/j.pneurobio.2025.102719 ISSN or title: 0301-0082
  • Brain Stimulation, Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo
    Name: Garrido-Charles, Aida; Bosch, Miquel; Lee, Hyojung; Rovira, Xavier; Pittolo, Silvia; Llobet, Artur; Wong, Hovy Ho Wai; Trapero, Ana; Matera, Carlo; Papotto, Claudio; Serra, Carme; Llebaria, Amadeu; Soriano, Eduardo; Sanchez-Vives, Maria V.; Holt, Christine E.; Gorostiza, Pau Role: Autor Publishing date: 2025
    Start page: 1779 End page: 1793 Vol.: 18 No.: 6
    DOI: 10.1016/j.brs.2025.09.005 ISSN or title: 1935-861X
  • Nanoscale Horizons, Chronic full-band recordings with graphene microtransistors as neural interfaces for discrimination of brain states
    Name: Camassa, A.; Barbero-Castillo, A.; Bosch, M.; Dasilva, M.; Masvidal-Codina, E.; Villa, R.; Guimerà-Brunet, A.; Sanchez-Vives, M. V. Role: Autor Publishing date: 2024
    Start page: 589 End page: 597 Vol.: 9 No.: 4
    DOI: 10.1039/d3nh00440f ISSN or title: 2055-6756
  • Cerebral cortex, Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2)
    Name: Ortega-Gasco, Alba; Parcerisas, Antoni; Hino, Keiko; Herranz-Perez, Vicente; Ulloa, Fausto; Elias-Tersa, Alba; Bosch, Miquel; Garcia-Verdugo, Jose Manuel; Simo, Sergi; Pujadas, Lluis; Soriano, Eduardo Role: Autor Publishing date: 2023
    Start page: 10931 End page: 10948 Vol.: 33 No.: 21
    DOI: 10.1093/cercor/bhad340 ISSN or title: 1047-3211
  • bioRxiv, Regulation of adult neurogenesis and neuronal differentiation by Neural Cell Adhesion Molecule 2 (NCAM2)
    Name: Ortega-Gascó, A.; Parcerisas Mosqueda, Antoni; Hino, K.; Herranz, V.; Ulloa, F.; Elias, A.; Bosch Pita, Miguel; García, J.; Simó, S.; Pujadas, L.; Soriano, E. Role: Autor Publishing date: 2022
    DOI: 10.1101/2022.02.03.478938
  • Science Signaling, The elongation factor eEF1A2 controls translation and actin dynamics in dendritic spines
    Name: Mendoza, Mònica B.; Gutierrez, Sara; Ortiz, Raúl; Moreno, David F.; Dermit, Maria; Dodel, Martin; Rebollo, Elena; Bosch, Miquel; Mardakheh, Faraz K.; Gallego, Carme Role: Autor Publishing date: 2021
    Vol.: 14 No.: 691
    DOI: 10.1126/SCISIGNAL.ABF5594 ISSN or title: 1945-0877
  • Molecular psychiatry, Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice
    Name: Thomazeau, Aurore; Bosch, Miquel; Essayan-Perez, Sofia; Barnes, Stephanie A.; De Jesus-Cortes, Hector; Bear, Mark F. Role: Autor Publishing date: 2021
    Start page: 4652 End page: 4669 Vol.: 26 No.: 9
    DOI: 10.1038/s41380-020-0821-6 ISSN or title: 1359-4184
  • International Journal of Molecular Sciences, New partners identified by mass spectrometry assay reveal functions of NCAM2 in neural cytoskeleton organization
    Name: Parcerisas, Antoni; Ortega‐gascó, Alba; Hernaiz‐llorens, Marc; Odena, Maria Antonia; Ulloa, Fausto; de Oliveira, Eliandre; Bosch, Miquel; Pujadas, Lluís; Soriano, Eduardo Role: Autor Publishing date: 2021
    Vol.: 22 No.: 14
    DOI: 10.3390/ijms22147404 ISSN or title: 1661-6596
  • Cell Chemical Biology, Photocontrol of Endogenous Glycine Receptors In Vivo
    Name: Gomila, Alexandre M.J.; Rustler, Karin; Maleeva, Galyna; Nin-Hill, Alba; Wutz, Daniel; Bautista-Barrufet, Antoni; Rovira, Xavier; Bosch, Miquel; Mukhametova, Elvira; Petukhova, Elena; Ponomareva, Daria; Mukhamedyarov, Marat; Peiretti, Franck; Alfonso-Prieto, Mercedes; Rovira, Carme; König, Burkhard; Bregestovski, Piotr; Gorostiza, Pau Role: Autor Publishing date: 2020
    Start page: 1425 End page: 1433.e7 Vol.: 27 No.: 11
    DOI: 10.1016/j.chembiol.2020.08.005 ISSN or title: 2451-9456
  • Nature Communications , Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation
    Name: Cabré, Gisela; Garrido-Charles, Aida; Moreno, Miquel; Bosch, Miquel; Porta-de-la-Riva, Montserrat; Krieg, Michael; Gascón-Moya, Marta; Camarero, Núria; Gelabert, Ricard; Lluch, José M.; Busqué, Félix; Hernando, Jordi; Gorostiza, Pau; Alibés, Ramon Role: Autor Publishing date: 2019
    Vol.: 10 No.: 1
    DOI: 10.1038/s41467-019-08796-9
  • Proceedings of the National Academy of Sciences of the United States of America, Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology
    Name: Pittolo, Silvia; Lee, Hyojung; Lladó, Anna; Tosi, Sébastien; Bosch, Miquel; Bardia, Lídia; Gómez-Santacana, Xavier; Llebaria, Amadeu; Soriano, Eduardo; Colombelli, Julien; Poskanzer, Kira E.; Perea, Gertrudis; Gorostiza, Pau Role: Autor Publishing date: 2019
    Start page: 13680 End page: 13689 Vol.: 116 No.: 27
    DOI: 10.1073/pnas.1900430116 ISSN or title: 0027-8424
  • Neuron, Structural and molecular remodeling of dendritic spine substructures during long-term potentiation
    Name: Bosch, Miquel; Castro, Jorge; Saneyoshi, Takeo; Matsuno, Hitomi; Sur, Mriganka; Hayashi, Yasunori Role: Autor Publishing date: 2014
    Start page: 444 End page: 459 Vol.: 82 No.: 2
    DOI: 10.1016/j.neuron.2014.03.021 ISSN or title: 0896-6273
  • Metallomics, Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc
    Name: Huang, Zhen; Zhang, Xiao An; Bosch, Miquel; Smith, Sarah J.; Lippard, Stephen J. Role: Autor Publishing date: 2013
    Start page: 648 End page: 655 Vol.: 5 No.: 6
    DOI: 10.1039/c3mt00103b ISSN or title: 1756-5901
  • PLoS ONE, Multisensory information facilitates reaction speed by enlarging activity difference between superior colliculus hemispheres in rats
    Name: Hirokawa, Junya; Sadakane, Osamu; Sakata, Shuzo; Bosch, Miquel; Sakurai, Yoshio; Yamamori, Tetsuo Role: Autor Publishing date: 2011
    Vol.: 6 No.: 9
    DOI: 10.1371/journal.pone.0025283
  • Physiology, The roles of CaMKII and F-Actin in the structural plasticity of dendritic Spines
    Name: Okamoto, Kenichi; Bosch, Miquel; Hayashi, Yasunori Role: Autor Publishing date: 2009
    Start page: 357 End page: 366 Vol.: 24 No.: 6
    DOI: 10.1152/physiol.00029.2009 ISSN or title: 1548-9213
  • Neuroscience, Functional role of the secondary visual cortex in multisensory facilitation in rats
    Name: Hirokawa, J.; Bosch, M.; Sakata, S.; Sakurai, Y.; Yamamori, T. Role: Autor Publishing date: 2008
    Start page: 1402 End page: 1417 Vol.: 153 No.: 4
    DOI: 10.1016/j.neuroscience.2008.01.011 ISSN or title: 0306-4522
  • European Journal of Neuroscience, Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain
    Name: Ginés, Silvia; Bosch, Miquel; Marco, Sonia; Gavaldà, Núria; Díaz-Hernández, Miguel; Lucas, José J.; Canals, Josep M.; Alberch, Jordi Role: Autor Publishing date: 2006
    Start page: 649 End page: 658 Vol.: 23 No.: 3
    DOI: 10.1111/j.1460-9568.2006.04590.x ISSN or title: 0953-816X
  • Journal of neurochemistry, Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    Name: Pineda, José R.; Canals, Josep M.; Bosch, Miquel; Adell, Albert; Mengod, Guadalupe; Artigas, Francesc; Ernfors, Patrik; Alberch, Jordi Role: Autor Publishing date: 2005
    Start page: 1057 End page: 1068 Vol.: 93 No.: 5
    DOI: 10.1111/j.1471-4159.2005.03047.x ISSN or title: 0022-3042
  • Molecular therapy, Long-term expression of erythropoietin from myoblasts immobilized in biocompatible and neovascularized microcapsules
    Name: Orive, G.; De Castro, M.; Ponce, S.; Hernández, R. M.; Gascón, A. R.; Bosch, M.; Alberch, J.; Pedraz, José L. Role: Autor Publishing date: 2005
    Start page: 283 End page: 289 Vol.: 12 No.: 2
    DOI: 10.1016/j.ymthe.2005.04.002 ISSN or title: 1525-0016
  • Experimental Neurology, Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease
    Name: Bosch, Miquel; Pineda, José R.; Suñol, Cristina; Petriz, Jordi; Cattaneo, Elena; Alberch, Jordi; Canals, Josep M. Role: Autor Publishing date: 2004
    Start page: 42 End page: 58 Vol.: 190 No.: 1
    DOI: 10.1016/j.expneurol.2004.06.027 ISSN or title: 0014-4886
  • Journal of neuroscience, Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease
    Name: Canals, Josep M.; Pineda, José R.; Torres-Peraza, Jesus F.; Bosch, Miquel; Martín-Ibañez, Raquel; Muñoz, M. Teresa; Mengod, Guadalupe; Ernfors, Patrik; Alberch, Jordi Role: Autor Publishing date: 2004
    Start page: 7727 End page: 7739 Vol.: 24 No.: 35
    DOI: 10.1523/JNEUROSCI.1197-04.2004 ISSN or title: 0270-6474
  • Photomarking Relocalization Technique for Correlated Two-Photon and Electron Microscopy Imaging of Single Stimulated Synapses. Methods in Molecular Biology
    Name: Bosch, Miquel; Castro, Jorge; Sur, Mriganka; Hayashi, Yasunori Role: Autor Publishing date: 2025
    Start page: 145 End page: 175
  • Molecular mechanisms underlying synaptic tagging and consolidation. Synaptic tagging and capture
    Name: Hayashi, Y.; Bosch Pita, Miguel; Hosokawa, T.; Liu, P.; Saneyoshi, T. Role: Autor Publishing date: 2024
  • Molecular mechanisms underlying synaptic tagging and consolidation. Synaptic Tagging and Capture
    Name: Hayashi, Yasunori; Bosch, Miquel; Liu, Pin Wu; Hosokawa, Tomohisa; Saneyoshi, Takeo Role: Autor Publishing date: 2024
    Start page: 63 End page: 76
    ISBN: 9783031548635
  • Photomarking relocalization technique for correlated two-photon and electron microcopy imaging of single stimulated synapses. Methods in Molecular Biology
    Name: Bosch, Miquel; Castro, Jorge; Sur, Mriganka; Hayashi, Yasunori Role: Autor Publishing date: 2017
    Start page: 185 End page: 214
  • Photomarking Relocalization Technique for Correlated Two-Photon and Electron Microcopy Imaging of Single Stimulated Synapses. Synapse Development: Methods in Molecular Biology.
    Name: Bosch Pita, Miguel Role: Autor Publishing date: 2016
    Start page: 185 End page: 214
    ISBN: 978-1-4939-6688-2
  • Roles of neuronal activity-induced gene products in hebbian and homeostatic synaptic plasticity, tagging, and capture. Synaptic Plasticity
    Name: Hayashi, Yasunori; Okamoto, Ken Ichi; Bosch, Miquel; Futai, Kensuke Role: Autor Publishing date: 2012
    Start page: 335 End page: 354
    ISBN: 9783709109311
Course 2026-2027 - Period: 01/09/2026 - 31/08/2027
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Neuroscience Applied to Orthoprosthesis
    • - Cell and Molecular Biology
    Bachelor's Degree in Biomedical Sciences
    • - Final Degree Project
    • - Physiopathology of the Nervous System
    • - External Laboratory Practices
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Cell Biology I
    • - Cell Biology II
Course 2025-2026 - Period: 01/09/2025 - 31/08/2026
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    • - Neuroscience Applied to Orthoprosthesis
    Bachelor's Degree in Biomedical Sciences
    • - Final Degree Project
    • - Cell Biology I
    • - Physiopathology of the Nervous System
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Cell Biology II
    • - External Laboratory Practices
    Bachelor's Degree in Humanities and Cultural Studies
    • - Theory of Knowledge
Course 2024-2025 - Period: 01/09/2024 - 31/08/2025
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    • - Neuroscience Applied to Orthoprosthesis
    Bachelor's Degree in Biomedical Sciences
    • - Cell Biology II
    • - Cell Biology I
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Physiopathology of the Nervous System
    Bachelor's Degree in Humanities and Cultural Studies
    • - Theory of Knowledge
Course 2023-2024 - Period: 01/09/2023 - 31/08/2024
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    Bachelor's Degree in Biomedical Sciences
    • - Work Placement
    • - Cell Biology I
    • - Cell Biology II
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Physiopathology of the Nervous System
    • - Final Degree Project
Course 2022-2023 - Period: 01/09/2022 - 31/08/2023
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    • - In-Company Training
    • - Final Degree Project
    Bachelor's Degree in Biomedical Sciences
    • - Work Placement
    • - Cell Biology II
    • - Cell Biology I
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Final Degree Project
    • - Physiopathology of the Nervous System
Course 2021-2022 - Period: 01/09/2021 - 31/08/2022
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    Bachelor's Degree in Biomedical Sciences
    • - Cell Biology II
    • - Cell Biology I
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Final Degree Project
    • - Work Placement
    • - Physiopathology of the Nervous System
Course 2020-2021 - Period: 01/09/2020 - 31/08/2021
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    Bachelor's Degree in Biomedical Sciences
    • - Cell Biology I
    • - Molecular Biology
    • - Cell Biology II
    • - Structure and Function of the Integration Systems: Nervous and Endocrine
    • - Physiopathology of the Nervous System
Course 2019-2020 - Period: 01/09/2019 - 31/08/2020
  • Bachelor's Degree
    Bachelor's Degree in Bioengineering
    • - Cell and Molecular Biology
    Bachelor's Degree in Medicine
    • - Cell Biology