Facultat de Medicina i Ciències de la Salut
Departament de Ciències Bàsiques de Ciències de la Salut
Fotografia del professor

Formació Acadèmica de la Dra. RODRÍGUEZ RODRÍGUEZ, Rosalía

  • Doctorat en Farmacia (2006)
    Universidad de Sevilla
  • Licenciada en Farmacia
    Universidad de Sevilla (2001)
  • Experto Universitario en Atención Farmacéutica
    Universidad de Sevilla (2004)

Publicacions de la Dra. RODRÍGUEZ RODRÍGUEZ, Rosalía


  • Rodríguez, R.; Ackermann, T. N.; Plaza, Jose A; Simonsen, Ulf; Matchkov, V.; Llobera, A.; Muñoz-Berbel, X., 2019, "Ultrasensitive photonic microsystem enabling sub-micrometric monitoring of arterial oscillations for advanced cardiovascular studies", Frontiers in Physiology, 10.
  • Márquez, A.; Aymerich, J.; Dei, M.; Rodríguez, R.; Vázquez-Carrera, M.; Pizarro-Delgado, J.; Giménez-Gómez, P.; Merlos, Á.; Terés, L.; Serra-Graells, F.; Jiménez-Jorquera, C.; Domínguez-Horna, C.; Muñoz-Berbel, X., 2019, "Reconfigurable multiplexed point of Care System for monitoring type 1 diabetes patients", Biosensors and bioelectronics, 136, 38-46.
  • Miralpeix, C.; Fosch, A.; Casas, J.; Baena, M.; Herrero, L.; Serra, D.; Rodríguez, R.; Casals, N, 2019, "Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice", Journal of lipid research, 60, 1260-1269.
  • Rodríguez, R.; Miralpeix, C.; Fosch, A.; Pozo Ariza, M; Calderón Domínguez, M.; Perpinyà, X.; Vellvehi, M.; López, M.; Herrero, L.; Serra, D.; Casals, N, 2019, "CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity", Molecular Metabolism, 19, 75-85.
  • Sandoval, V.; Rodríguez, R.; Martinez-Garza, U.; Rosell-Cardona, C.; Lamuela Raventos, R.; Marrero, P.; Haro, D.; Relat, J., 2018, "Mediterranean Tomato-Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese Zucker Rats", Molecular nutrition and food research, 62.
  • Hofmann, K.; Rodríguez, R.; Gaebler, A.; Casals, N; Scheller, A.; Kuerschner, L., 2017, "Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids", Scientific Reports, 7.
  • Rodríguez, R.; Jimenez-Altayo, F.; Alsina, L.; Onetti, Y.; Rinaldi de Alvarenga, J.; Claro, C.; Ogalla, E.; Casals, N; Lamuela Raventos, R., 2017, "Mediterranean tomato-based sofrito protects against vascular alterations in obese Zucker rats by preserving NO bioavailability", Molecular nutrition and food research, 61.
  • Pozo Ariza, M; Rodríguez, R.; Ramírez, S.; Seoane Collazo, P.; López, M.; Serra, D.; Herrero, L.; Casals, N, 2017, "Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice", Endocrinology.
  • de Pedro, S.; Muñoz, X.; Rodríguez, R.; Sort, J.; Plaza, J.; Brugger, J.; Llobera, A.; Cadarso, V., 2016, "Characterization of Ferrofluid-Based Stimuli-Responsive Elastomers", Frontiers in Mechanical Engineering.
  • Gimenez-Gomez, P.; Rodríguez, R.; Muñoz-Berbel, X.; Rios, J.; Gonzalez, E.; Plaza, Jose A; Jiménez-Jorquera, C., 2016, "Silicon-glass LoC for reliable multi-parametric cell culture monitoring and advanced imaging", International Conference on Miniaturized Systems for Chemistry and Life Sciences.
  • Justo, M.; Claro, C.; Zeyda, M.; Stulnig, T.; Herrera, M.; Rodríguez, R., 2016, "Rice bran prevents high-fat diet-induced inflammation and macrophage content in adipose tissue", European Journal of Nutrition-esborrar, 55, 2011-2019.
  • Perez-Ternero, C.; Rodríguez, R.; Herrera, M.; Alvarez de Sotomayor, M., 2016, "Diet supplementation with rice bran enzymatic extract restores endothelial impairment and wall remodelling of ApoE-/- mice microvessels", Atherosclerosis, 250, 15-22.
  • Alonso, A.; Vigues, N.; Rodríguez, R.; Borrisé, X.; Muñoz, M.; Muraviev, D.; Mas, J.; Muñoz-Berbel, X., 2016, "Self-oriented Ag-based polycrystalline cubic nanostructures through polymer stabilization", Nanotechnology, in press.
  • Casals, N; Zammit, V.; Herrero, L.; Fadó, R.; Rodríguez, R.; Serra, D., 2016, "Carnitine palmitoyltransferase 1C: From cognition to cancer", Progress in lipid research, 61, 134-148.
  • Alonso, A.; Vigues, N.; Rodríguez, R.; Borrisé, X.; Muñoz, M.; Muraviev, D.; Mas, J.; Muñoz-Berbel, X., 2015, "Activity-tunable nanocomposites based on dissolution and in situ recrystallization of nanoparticles on ion exchange resins", RSC Advances, 109, 89971-89975.
  • Barroso, E.; Rodríguez, R.; Chacon, M R.; Maymó-Masip, E.; Ferrer, L.; Salvado, L.; Salmeron, E.; Wabistch, M.; Palomer, X.; Vendrell, J.; Wahli, W.; Vazquez-Carrera, M., 2015, "PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation", Biochimica et biophysica acta. Molecular basis of disease, 1852, 1049-1058.
  • Claro, C.; Ogalla, E.; Rodríguez, R.; Herrera, M.; Alvarez de Sotomayor, M., 2015, "Phenolic content of extra virgin olive oil is essential to restore endothelial dysfunction but not to prevent vascular inflammation in atherosclerotic lesions of Apo E deficient mice", Journal of functional foods, 15, 126-136.
  • Rodríguez, R., 2015, "Oleanolic Acid and Related Triterpenoids from Olives on Vascular Function: Molecular Mechanisms and Therapeutic Perspectives", Current medicinal chemistry, 22, 1414-1425.
  • Ogalla, E.; Claro, C.; Alvarez de Sotomayor, M.; Herrera, M.; Rodríguez, R., 2015, "Structural, mechanical and myogenic properties of small mesenteric arteries from ApoE KO mice: Characterization and effects of virgin olive oil diets", Atherosclerosis, 238, 55-63.
  • Justo, M.; Claro, C.; Vila, E.; Herrera, M.; Rodríguez, R., 2014, "Microvascular disorders in obese Zucker rats are restored by a Rice bran diet", Nutrition metabolism and cardiovascular diseases, 24, 524-531.
  • Candiracci, M.; Justo, M.; Castaño, A.; Rodríguez, R.; Herrera, M., 2014, "Rice Bran Enzymatic Extract-supplemented diets modulate adipose tissue inflammation markers in Zucker rats", Nutrition, 30, 466-472.
  • Perez-Ternero, C.; Rodríguez, R.; Parrado, J.; Alvarez de Sotomayor, M., 2013, "Grape pomace enzymatic extract restores vascular dysfunction evoked by endothelin-1 and DETCA via NADPH oxidase downregulation and SOD activation", Journal of functional foods, 5, 1673-1683.
  • Muñoz-Berbel, X.; Rodríguez, R.; Vigués, N.; Mas, J.; Verpoorte, E.; Llobera, A., 2013, "Monolithically integrated biophotonic lab-on-a-chip for cell culture and simultaneous pH monitoring", Lab on a chip, 4239-4247.
  • Justo, M.; Candiracci, M.; Dantas, A.; Vila, E.; Herrera, M.; Rodríguez, R., 2013, "Rice bran enzymatic extract restores endothelial function and vascular contractility in obese rats by reducing vascular inflammation and oxidative stress", Journal of nutritional biochemistry, 24, 1453-1461.
  • Alonso, A.; Vigues, N.; Muñoz-Berbel, X.; Rodríguez, R.; Mas, J.; Muraviev, D., 2013, "Superparamagnetic Ag@Co-nanocomposites on granulated cation exchange polymeric matrices with enhanced antibacterial activity for the environmentally safe purification of water", Advanced functional materials, 23, 2450-2458.
  • Barroso, E.; Del Valle, J.; Porquet, D.; Vieira Santos, A.; Salvado, L.; Rodríguez, R.; Gutierrez, P.; Anglada-Huguet, M.; Alberch, J.; Camins, A.; Palomer, X.; Pallas, M.; Michalik, L.; Wahli, W.; Vazquez-Carrera, M., 2013, "Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARb/g-null mice", Biochimica et biophysica acta. Molecular basis of disease, 1832, 1241-1248.
  • Justo, M.; Rodríguez, R.; Claro, C.; Alvarez de Sotomayor, M.; Parrado, J.; Herrera, M., 2013, "Water-soluble rice bran enzymatic extract attenuates dyslipidemia, hypertension and insulin resistance in obese Zucker rats", European journal of nutrition, 52, 789-797.
  • Rodríguez, R.; Justo, M.; Claro, C.; Vila, E.; Parrado, J.; Herrera, M.; Alvarez de Sotomayor, M., 2012, "Endothelium-dependent vasodilator and antioxidant properties of a novel enzymatic extract of grape pomace from wine industrial waste", Food chemistry, 135, 1044-1051.
  • Rodríguez, R.; Simonsen, Ulf, 2012, "Measurement of nitric oxide and reactive oxygen species in the vascular wall", Current analytical chemistry, 8, 485-494.
  • Rodríguez, R.; Muñoz-Berbel, X.; Demming, S.; Buttgenbach, S.; Herrera, M.; Llobera, A., 2012, "Cell-based microfluidic device for screening anti-proliferative activity of drugs in vascular smooth muscle cells", Biomedical microdevices, 14, 1129-1140.
  • Alonso, A.; Muñoz-Berbel, X.; Vigues, N.; Rodríguez, R.; Macanás, J.; Mas, J.; Muñoz, M.; Muraviev, D., 2012, "Intermatrix synthesis of monometallic and magnetic metal/metal oxide nanoparticles with bactericidal activity on anionic exchange polymers", RSC Advances, 11, 4596-4599.
  • Buus, N.; Rodríguez, R.; Hansson, N.; Stankevicious, E.; Andersen, M.; Simonsen, Ulf, 2011, "Antiatherogenic effects of oleanolic acid in apolipoprotein e knockout mice", European journal of pharmacology, 670, 519-526.
  • Mingorance, C.; Rodríguez, R.; Justo, M.; Alvarez de Sotomayor, M.; Herrera, M., 2011, "Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders", Vascular health and risk management (Online), 7, 169-176.
  • Mingorance, C.; Rodríguez, R.; Justo, M.; Herrera, M.; Alvarez de Sotomayor, M., 2011, "Pharmacological effects and clinical applications of propionyl-L-carnitine", Nutrition reviews, 69, 279-290.
  • Herrera, M.; Mingorance, C.; Rodríguez, R.; Alvarez de Sotomayor, M., 2010, "Endothelial dysfunction and aging: An update", Ageing research reviews, 9, 142-152.
  • Simonsen, Ulf; Rodríguez, R.; Daalsgard, T.; Buus, N.; Stankevicious, E., 2009, "Novel approaches to improving endothelium-dependent nitric oxide-mediated vasodilatation", Pharmacological reports, 61, 105-115.
  • Rodríguez, R.; Yarova, P.; Winter, P.; Dora, K., 2009, "Desensitization of endothelial P2Y1 receptors by PKC-dependent mechanisms in pressurized rat small mesenteric arteries", British journal of pharmacology, 158, 1609-1620.
  • Rodríguez, R.; Herrera, M.; Alvarez de Sotomayor, M.; Ruiz-Gutierrez, V., 2009, "Effects of pomace olive oil-enriched diets on endothelial function of small mesenteric arteries from spontaneously hypertensive rats", British journal of nutrition, 102, 1435-1444.
  • Rodríguez, R.; Stankevicious, E.; Herrera, M.; Ostergaard, L.; Andersen, M.; Ruiz-Gutierrez, V.; Simonsen, Ulf, 2008, "Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide", British journal of pharmacology, 155, 535-546.
  • Martinez-Gonzalez, J.; Rodríguez, R.; Gonzalez-Diez, M.; Rodriguez, C.; Herrera, M.; Ruiz-Gutierrez, V.; Badimón, L., 2008, "Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism", Journal of nutrition, 138, 443-448.
  • Alvarez de Sotomayor, M.; Mingorance, C.; Rodríguez, R.; Marhuenda, E.; Herrera, M., 2007, "L-carnitine and its propionate: Improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms", Free radical research, 41, 884-891.
  • Rodríguez, R.; Herrera, M.; Alvarez de Sotomayor, M.; Ruiz-Gutierrez, V., 2007, "Pomace Olive Oil Improves Endothelial Function in Spontaneously Hypertensive Rats by Increasing Endothelial Nitric Oxide Synthase Expression", American journal of hypertension, 20, 728-724.
  • Rodríguez, R.; Sanchez-Perona, J.; Herrera, M.; Ruiz-Gutierrez, V., 2006, "Triterpenic compounds from "Orujo" olive oil elicit vasorelaxation in aorta from spontaneously hypertensive rats", Journal of agricultural and food chemistry, 54, 2096-2102.
  • Herrera, M.; Rodríguez, R.; Ruiz-Gutierrez, V., 2006, "Functional properties of pentacyclic triterpenes contained in "orujo" olive oil", Current nutrition and food science, 2, 45-49.
  • Sanchez-Perona, J.; Rodríguez, R.; Ruiz-Gutierrez, V., 2005, "Effects of oleic acid rich oils on aorta lipids and lipoprotein lipase activity of spontaneously hypertensive rats", Journal of agricultural and food chemistry, 53, 7330-7336.
  • Rodríguez, R.; Herrera, M.; Sanchez-Perona, J.; Ruiz-Gutierrez, V., 2004, "Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta", British journal of nutrition, 92, 635-642.

Capítols de llibre

  • Rodríguez, R.; Simonsen, Ulf, 01/04/2014, "Natural triterpenoids from olive oil: Potential activities against cancer", Natural Compounds as Inducers of Cell Death, 447-461.
  • Rodríguez, R.; Ruiz-Gutierrez, V., 01/01/2010, "Functional Properties of Pentacyclic Triterpenes Contained in Pomace Olive Oil", Olives and Olive Oil in Health and Disease Prevention, 1431-1438.
  • Rodríguez, R.; Ruiz-Gutierrez, V., 01/01/2010, "Vasorelaxant Effects of Oleanolic Acid and Erythrodiol in Pomace Olive Oil", Olives and Olive Oil in Health and Disease Prevention, 813-820.
  • Rodríguez, R.; Ruiz-Gutierrez, V., 01/01/2009, "Minor components from olive oil: their most promising biological activities", Advances in Olive Resources, 79-104.

Projectes de recerca de la Dra. RODRÍGUEZ RODRÍGUEZ, Rosalía

  • Administracion de fármacos específicos de la CPT1 central: una novedosa estrategia basada en nanomedicina para combatir obesidad y cáncer.
  • Cpt1c en el hipotálamo ventromedial como nueva diana terapéutica en la regulación del balance energético: mecanismos moleculares implicados.
  • Carnitine palmitoyltransferase 1-mediated strategies to activate brown fat and reduce food intake to fight against obesity.
  • Papel de la carnitina pamitoil transferasa 1C como sensor hipotalámico de aciles-CoA y regulador del metabolismo periférico de los lípidos (SAF2014-52223-C2-2-R).
  • Componentes bioactivos del sofrito. Estudio metabolómico y mecanismos implicados en el control de estres oxidativo e inflamación.
  • Investigación y desarrollo de nuevas posibilidades de aplicaciones terapéuticas en el aceite de oliva.
  • Caracterizacion de las propiedades funcionales a nivel cardiovascular y del sindrome metabolico de un extracto enzimatico del salvado de arroz (AGL2009-11559 ALI).
  • Estudio de biodisponibilidad de los triterpenos del aceite de orujo y su papel sobre procesos implicados en la formacion de la placa de ateroma (AGL2008-02285 ALI).
  • Investigacion cientifica dirigida al desarrollo de una nueva generacion de alimentos para el control de peso y prevencion de obesidad (PRONAOS).