Role of the Atypical Cyclins in the control of mammalian cell cycle

The cell cycle in eukaryotic cells is governed by a family of proteins called cyclin-dependent kinases (CDKs). The activity of these CDKs is tightly regulated through their interaction with other proteins known as cyclins.

The Human Genome Project has identified several new or atypical cyclins and new CDKs whose roles have not yet been established.

Our objective is to characterize the role of these mammalian atypical cyclins in both physiological and pathological situations. We are specifically interested in the study of these CDK-Atypical Cyclin complexes in stem cells and cancer.