Directori
CASALS FARRÉ, Núria
Ext. 5223, 4240
Departament de Ciències Bàsiques
From cell metabolism to metabolic diseases (METADIS)
CASALS FARRÉ, Núria
CV
Perfil del professor
Professor Catedràtic
Ciències Bàsiques, DEPARTAMENT DE CIÈNCIES BÀSIQUES. Universitat Internacional de Catalunya
Formació Acadèmica
- Doctora en Farmàcia Universitat de Barcelona
- Master en Economia de la Salut i Gestió Sanitària Universitat de Barcelona/Universitat Pompeu Fabra
- Farmàcia Universitat de Barcelona
Publicacions
Articles
- Zagmutt, S.; Mera, P.; González, I.; Ibeas, K.; Romero, M.; Obri, A.; Martin, B.; Esteve, A.; Soler-Vázquez, M.C.; Bastias, M.; Cañes, L.; Augé, E.; Pelegri, C.; Vilaplana, J.; Ariza, X.; García, J.; Martinez, J.; Casals, N; López, M.; Palmiter, R.; Sanz, E.; Quintana, A.; Herrero, L.; Serra, D., (2023), "CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst", Biology of Sex Differences, vol. 14, No. 1, ISSN: 2042-6410.
- Soler-Vázquez, M.C.; Romero, M.; Todorcevic, M.; Delgado, K.; Calatayud, C.; Benitez, A.; La Chica, M.; Mera, P.; Zagmutt, S.; Bastías, M.; Ibeas, K.; Casals, N; Escolà, J.; Llorente-Cortés, V.; Consiglio, A.; Serra, D.; Herrero, L., (2023), "Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice", Metabolic engineering, vol. 77, pp. 256-272, ISSN: 1096-7176.
- Iborra, G.; Djebari, S.; Sánchez, I.; Gratacòs, E.; Sánchez, N.; Radošević, M.; Casals, N; de Dios, J.; Soto, D.; Jiménez, L., (2023), "CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non-associative learning", Journal of Physiology, vol. 601, No. 16, pp. 3533-3556, ISSN: 1469-7793.
- Louail, A.; Bengoetxea, I.; Rojas, R.; Casals, N, (2023), "XIth Cajal Conference: New frontiers in neuron-glial plasticity in health and disease", European journal of neuroscience, vol. 57, No. 9, pp. 1447-1465, ISSN: 0953-816X.
- Garcia, J.; Paraiso, W.; Zagmutt, S.; Fosch, A.; Reguera, AC.; Alzina, S.; Sánchez, L.; Fukushima, S.; Toh, K.; Casals, N; Serra, D.; Herrero, L.; Garcia, J.; Kataoka, K.; Ariza, X.; Quader, S.; Rodriguez-Rodriguez, R., (2023), "Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance", Biomaterials science, vol. 11, pp. 2336-2347, ISSN: 2047-4830.
- Rodriguez-Rodriguez, R.; Fosch, A.; Garcia, J.; Zagmutt, S.; Casals, N, (2023), "Targeting carnitine palmitoyltransferase 1 isoforms in the hypothalamus: A promising strategy to regulate energy balance", JOURNAL OF NEUROENDOCRINOLOGY, vol. 35, No. 9, ISSN: 1365-2826.
- Fadó, R.; Zagmutt, S.; Herrero, L.; Muley, H.; Rodriguez-Rodriguez, R.; Bi, H.; Serra, D.; Casals, N, (2023), "To be or not to be a fat burner, that is the question for cpt1c in cancer cells", Cell death and disease, vol. 14, No. 1, ISSN: 2041-4889.
- Fosch, A.; Rodriguez, M.; Miralpeix, C.; Zagmutt, S.; Larrañaga, M.; Reguera, AC.; Garcia, J.; Herrero, L.; Serra, D.; Casals, N; Rodriguez-Rodriguez, R., (2023), "Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids", International Journal of Molecular Sciences, vol. 24, No. 2, ISSN: 1422-0067.
- Muley, H.; Valencia, K.; Casas, J.; Moreno, B.; Botella, L.; Lecanda, F.; Fadó, R.; Casals, N, (2023), "Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer", International Journal of Molecular Sciences, vol. 24, No. 2, ISSN: 1422-0067.
- Fadó, R.; Molins, A.; Rojas, R.; Casals, N, (2022), "Feeding the Brain: Effect of Nutrients on Cognition, Synaptic Function, and AMPA Receptors", Nutrients, vol. 14, No. 19, ISSN: 2072-6643.
- Miralpeix, C.; Reguera, AC.; Fosch, A.; Zagmutt, S.; Casals, N; Cota, D.; Rodriguez-Rodriguez, R., (2021), "Hypothalamic endocannabinoids in obesity: an old story with new challenges", Cellular and molecular life sciences, vol. 78, No. 23, pp. 7469-7490, ISSN: 1420-682X.
- Paraiso, W.; Garcia, J.; Ariza, J.; Zagmutt, S.; Fukushima, S.; Garcia, J.; Mochida, Y.; Serra, D.; Herrero, L.; Kinoh, H.; Casals, N; Kataoka, K.; Rodriguez-Rodriguez, R.; Quader, S., (2021), "Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells", Biomaterials science, vol. 9, No. 21, pp. 7076-7091, ISSN: 2047-4830.
- Lillo, J.; Lillo, A.; Zafra, D.A.; Miralpeix, C.; Rivas-Santisteban, R.; Casals, N; Navarro, G.; Franco, R., (2021), "Identification of the ghrelin and cannabinoid cb2 receptor heteromer functionality and marked upregulation in striatal neurons from offspring of mice under a high-fat diet", International Journal of Molecular Sciences, vol. 22, No. 16, ISSN: 1422-0067.
- Fosch, A.; Zagmutt, S.; Casals, N; Rodriguez-Rodriguez, R., (2021), "New insights of sf1 neurons in hypothalamic regulation of obesity and diabetes", International Journal of Molecular Sciences, vol. 22, No. 12, ISSN: 1422-0067.
- Miralpeix, C.; Reguera, AC.; Fosch, A.; Casas, M.; Lillo, J.; Navarro, G.; Franco, R.; Casas, J.; Alexander, S.P.H.; Casals, N; Rodriguez-Rodriguez, R., (2021), "Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status", British journal of pharmacology, vol. 178, No. 7, pp. 1507-1523, ISSN: 0007-1188.
- Fadó, R.; Rodriguez-Rodriguez, R.; Casals, N, (2021), "The return of malonyl-CoA to the brain: Cognition and other stories", Progress in lipid research, vol. 81, ISSN: 0163-7827.
- Heras, V.; Castellano, J.M.; Fernandois, D.; Velasco, I.; Rodríguez-Vázquez, E.; Roa, J.; Vazquez, M.J.; Ruiz-Pino, F.; Rubio, M.; Pineda, R.; Torres, E.; Avendaño, M.S.; Paredes, A.H.; Pinilla, L.; Belsham, D.D.; Diéguez, C.; Gaytán, F.; Casals, N; López, M.; Tena-Sempere, M., (2020), "Central ceramide signaling mediates obesity-induced precocious puberty", Cell metabolism, vol. 32, No. 6, pp. 951-966, ISSN: 1550-4131.
- Casas, M.; Fadó, R.; Domínguez, J.L.; Roig, A.; Kaku, M.; Chohnan, S.; Solé, M.; Unzeta, M.; Miñano-Molina, A.; Rodríguez, J.; Dickson, E.; Casals, N, (2020), "Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking", Journal of cell biology, vol. 219, No. 10, ISSN: 0021-9525.
- Weber, M.; Mera, P.; Casas, J.; Salvador, J.; Rodriguez, A.; Alonso, S.; Sebastián, D.; Soler-Vázquez, M.C.; Montironi, C.; Recalde, S.; Fucho, R.; Calderón Domínguez, M.; Mir, J.; Bartrons, R.; Escolá-Gil, J.; Sánchez-Infantes, D.; Zorzano, A.; Llorente-Cortés, V.; Casals, N; Valentí, V.; Frúhbeck, G.; Herrero, L.; Serra, D., (2020), "Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD", Faseb journal, vol. 34, No. 9, pp. 11816-11837, ISSN: 0892-6638.
- Garcia-Chica, J.; Paraiso, W.; Tanabe, S.; Serra, D.; Herrero, L.; Casals, N; Garcia, J.; Ariza, X.; Quader, S.; Rodriguez-Rodriguez, R., (2020), "An overview of nanomedicines for neuron targeting", Nanomedicine, vol. 15, No. 16, pp. 1617-1636, ISSN: 1743-5889.
- Muley, H.; Fadó, R.; Rodriguez-Rodriguez, R.; Casals, N, (2020), "Drug uptake-based chemoresistance in breast cancer treatment", Biochemica pharmacology, vol. 177, ISSN: 0006-2952.
- Cheng, W.; Siedlecki-Wullich, D.; Català-Solsona, J.; Fàbregas, C.; Fadó, R.; Casals, N; Solé, M.; Unzeta, M.; Saura, C.; Rodríguez, J.; Miñano-Molina, A., (2020), "Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD", eNeuro, vol. 7, No. 2, ISSN: 2373-2822.
- Palomo-Guerrero, M.; Fadó, R.; Casas, M.; Pérez-Montero, M.; Baena, M.; Helmer, PO.; Domínguez, JL.; Roig, A.; Serra, D.; Hayen, H.; Stenmark, H.; Raiborg, C.; Casals, N, (2019), "Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth", eLife, vol. 8, ISSN: 2050-084X.
- Solé, M.; Esteban, M.; Taltavull, B.; Fàbregas, C.; Fadó, R.; Casals, N; Rodríguez, J.; Miñano-Molina, A.; Unzeta, M., (2019), "Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition", Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1865, No. 9, pp. 2189-2202, ISSN: 1879-260X 09254439.
- Miralpeix, C.; Fosch, A.; Casas, J.; Baena, M.; Herrero, L.; Serra, D.; Rodriguez-Rodriguez, R.; Casals, N, (2019), "Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice", Journal of lipid research, vol. 60, No. 7, pp. 1260-1269, ISSN: 0022-2275.
- Rodriguez-Rodriguez, R.; Miralpeix, C.; Fosch, A.; Pozo Ariza, M; Calderón Domínguez, M.; Perpinyà, X.; Vellvehi, M.; López, M.; Herrero, L.; Serra, D.; Casals, N, (2019), "CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity", Molecular Metabolism, vol. 19, pp. 75-85, ISSN: 2212-8778.
- Gratacós, E.; Olivella, M.; Sánchez, N.; Yefimenko, N.; Miguez, F.; Fadó, R.; Casals, N; Gasull, X.; Ambrosio, S.; Soto, D., (2018), "Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement", Frontiers in Molecular Neuroscience, vol. 11, No. 275, ISSN: 1662-5099.
- Roa, X.; Al-Atari Abou-Asi, M; Fadó, R.; Mir, J.; Muley, H.; Serra, D.; Casals, N, (2018), "CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy", Scientific Reports, vol. 8, ISSN: 2045-2322.
- Mir, J.; Zagmutt, S.; Lichtenstein, M.; Casals, N; Herrero, L.; Serra, D., (2018), "Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex", Molecular neurobiology, vol. 55, pp. 7216-7228, ISSN: 0893-7648.
- Palomo-Guerrero, M.; Cosgaya, J.; Gella, A.; Casals, N; Grijota-Martinez,C., (2018), "Uridine-5'-triphosphate partially partially blocks differentiation signals and favors a more repair state in cultured rat Schwann cells", Neuroscience, ISSN: 0306-4522.
- Alcalá, M.; Calderón Domínguez, M.; Bustos, E.; Ramos, P.; Casals, N; Serra, D.; Viana, M.; Herrero, L., (2017), "Increased infammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice", Scientific Reports, vol. 7, ISSN: 2045-2322.
- Hofmann, K.; Rodriguez-Rodriguez, R.; Gaebler, A.; Casals, N; Scheller, A.; Kuerschner, L., (2017), "Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids", Scientific Reports, vol. 7, ISSN: 2045-2322.
- Rodriguez-Rodriguez, R.; Jimenez-Altayo, F.; Alsina, L.; Onetti, Y.; Rinaldi de Alvarenga, J.; Claro, C.; Ogalla, E.; Casals, N; Lamuela Raventos, R., (2017), "Mediterranean tomato-based sofrito protects against vascular alterations in obese Zucker rats by preserving NO bioavailability", Molecular nutrition and food research, vol. 61, No. 9, ISSN: 1613-4125.
- Martínez Sánchez, N.; Seoane Collazo, P.; Contreras, C.; Valera, L.; Villarroya, J.; Rial Pensado, E.; Buque, X.; Aurrekoetxea, I.; Delgado, M.; Martinez Vazquez, J.; Gonzalez, R.; Roa, J.; whittle, A.; Gomez, B.; Velagapudi, V.; Loraine, Y.; Morgan, D.; Voshol, P.; Martinez de morterin, P.; Lopez, T.; Linares Pose, L.; Gonzalez, F.; Chatterjee, K.; Sobrino, T.; Medina, G.; Davis, R.; Casals, N; Oresic, M.; Coll, A.; Vidal Puig, A.; Mittag, J.; Sempere, M.; Malagon, M.; Dieguez, C.; Martinez Chantar, M.; Espichueta, P.; Rahmouni, K.; Nogueiras, R.; Sabio, G.; Villarroya, F.; López, M., (2017), "Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance", Cell metabolism, vol. 26, No. 1, pp. 212-229, ISSN: 1550-4131.
- Pozo Ariza, M; Rodriguez-Rodriguez, R.; Ramírez, S.; Seoane Collazo, P.; López, M.; Serra, D.; Herrero, L.; Casals, N, (2017), "Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice", Endocrinology, ISSN: 1945-7170.
- Fucho, R.; Casals, N; Serra, D.; Herrero, L., (2017), "Ceramides and mitochondrial fatty acid oxidation in obesity", Faseb journal, vol. 31, No. 4, pp. 1263-1272, ISSN: 0892-6638.
- Contreras, C.; Gonzalez, Mj.; Seoane-Collazo, P.; Casals, N; Diéguez, C.; Nogueiras, R.; López, M., (2017), "Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity", Diabetes, vol. 66, No. 1, ISSN: 0012-1797.
- Palomo-Guerrero, M.; Fadó, R.; Moreno, B.; Rodríguez-Rodríguez, R.; Casals, N, (2016), "Abstracts of the XXXVIII Congress of the Spanish Society of Physiological Sciences (SECF), 13-16 September 2016, Zaragoza, Spain.", Journal of physiology and biochemistry, pp. S10-S11, ISSN: 1138-7548.
- Casals, N; Zammit, V.; Herrero, L.; Fadó, R.; Rodriguez-Rodriguez, R.; Serra, D., (2016), "Carnitine palmitoyltransferase 1C: From cognition to cancer", Progress in lipid research, vol. 61, pp. 134-148, ISSN: 0163-7827.
- Fadó, R.; Soto, D.; Minano-Molina, A.; Pozo Ariza, M; Carrasco, P.; Yefimenko, N.; Rodriguez-Alvarez, J.; Casals, N, (2015), "Novel Regulation of the Synthesis of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus", Journal of biological chemistry, vol. 290, No. 42, pp. 25548-25560, ISSN: 0021-9258.
- Rinaldi, C.; Schmidt, T.; Situ, A.; Johnson, J.; Lee, P.; Ke-lian, C.; Bott, L.; Fadó, R.; Harmison, G.; Parodi, S.; Grunseich, C.; Renvoise, B.; Biesecker, L.; De Michele, G.; Santorelli, F.; Filla, A.; Stevanin, G.; Duerr, A.; Brice, A.; Casals, N; Traynor, B.; Blackstone, C.; Ulmer, T.; Fischbeck, K., (2015), "Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia", JAMA Neurology, vol. 72, No. 5, pp. 561-570, ISSN: 2168-6149.
- Malandrino, M.; Fucho, R.; Weber, M.; Calderón Domínguez, M.; Mir, J.; Valcarcel, L.; Escote, X.; Gómez Serrano, M.; Peral, B.; Salvado, L.; Fernández Veledo, S.; Casals, N; Vázquez-Carrera, M.; Villarroya, F.; Vendrell, J.; Serra, D.; Herrero, L., (2015), "Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation", American journal of physiology. Endocrinology and metabolism, vol. 308, No. 9, ISSN: 0193-1849.
- Contreras, C.; González García, I.; Martínez Sánchez, N.; Seoane Collazo, P.; Jacas Mateu, J; Morgan, D.; Serra, D.; Gallego, R.; González, F.; Casals, N; Nogueiras, R.; Rahmouni, K.; Dieguez, C.; López, M., (2014), "Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance", Cell Reports, vol. 9, No. 1, pp. 366-377, ISSN: 2211-1247.
- Gao, S.; McMillan, R.; Jacas Mateu, J; Zhu, Q.; Li, X.; Kumar, G.; Casals, N; Hegardt, F.; Robbins, P.; Lopaschuk, G.; Hulver, M.; Butler, A., (2014), "Regulation of Substrate Oxidation Preferences in Muscle by the Peptide Hormone Adropin", Diabetes, vol. 63, No. 10, pp. 3242-3252, ISSN: 0012-1797.
- Lamarca, A.; Gella, A.; Martiañez, T.; Segura, M.; Figueiro, J.; Grijota-Martinez,C.; Trullas, R.; Casals, N, (2014), "Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation", PLoS One, vol. 9, No. 6, ISSN: 1932-6203.
- Hernández-Ortega, S; Bru, S.; Ricco, N.; Ramírez, S.; Casals, N; Jiménez, J.; Isasa, M.; Crosas, B.; Clotet, J., (2013), "Defective in Mitotic Arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.", The journal of biological chemistry (Versió web), vol. 288, No. 7, pp. 4704-4714, ISSN: 1083-351X.
- Martiáñez, T.; Lamarca, A.; Casals, N; Gella, A., (2013), "N-cadherin expression is regulated by UTP in schwannoma cells", Purinergic Signalling, vol. 9, pp. 259-270, ISSN: 1573-9538.
- Ramírez, S.; Martins, L.; Jacas Mateu, J; Carrasco, P.; Pozo Ariza, M; Clotet, J.; Serra, D.; Hegardt , FG.; Diéguez, C.; López, M.; Casals, N, (2013), "hypothalamic ceramide levels regulated by CPTC1C mediate the oxigenic effect of ghrelin", Diabetes, vol. 62, pp. 2329-2337, ISSN: 0012-1797.
- Gao, S.; Casals, N; keung, W.; Moran, TH.; Lopaschuk, GD., (2013), "Differential effects of central ghrelin on fatty acid metabolism in hypothalamic ventral medial and arcuate nuclei", Physiology and behavior, vol. 118, pp. 165-170, ISSN: 0031-9384.
- Carrasco, P.; Jacas Mateu, J; Sahún, I.; Muley, H.; Ramírez, S.; Puisac , B.; Mezquita, Pau; Pié, J.; Dierssen , M.; Casals, N, (2013), "Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity.", Behavioural brain research, vol. 256, pp. 291-297, ISSN: 0166-4328.
- Arnedo, M.; Menao, S.; Puisac, B.; Teresa-Rodrigo, ME; Maria, E.; Gil-Rodríguez, M.; Maria, C.; López-Viñas, E.; Gómez-Puertas, P.; Casals, N; Casale, Cesar H.; Hegardt , FG., (2012), "Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol", Journal of lipid research, vol. 53, No. 10, pp. 2046-2056, ISSN: 0022-2275.
- Puisac, B.; Ramos, M.; Arnedo, M.; Menao, S.; Gil-Rodríguez, M.; Teresa-Rodrigo, ME; Pié, A.; de Karam, JC; Wesselink, JJ; Giménez, I.; Ramos, FJ; Casals, N; Gómez-Puertas, P.; Hegardt , FG.; Pié, J., (2012), "Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway.", Mol Biol Rep, vol. 39, pp. 4777-4785.
- Carrasco, P.; Sahún, I.; McDonald, J.; Ramírez, S.; Jacas Mateu, J; Gratacós, E.; Sierra, AY; Serra, D.; Herrero, L.; Acker-Palmer, A.; Hegardt , FG.; Dierssen , M.; Casals, N, (2012), "Ceramide levels regulated by carnitine palmitoyl transferase 1C control dendritic spine maturation and cognition.", Journal of biological chemistry, ISSN: 0021-9258.
- Al-Atari Abou-Asi, M; Gil-Recio, C.; Fabregat, M.; García-Fernández, DA.; Barajas, M.; Carrasco, M.; Jung, H.; Hernandez Alfaro, F; Casals, N; Prósper, F.; Ferrés, E.; Giner Tarrida, L, (2012), "Dental Pulp of the Third Molar: A New Source of Pluripotent-like Stem Cells.", Journal of Cell Science, vol. 125, No. 14, pp. 3343-3356, ISSN: 0021-9533.
- Gella, A.; Martiañez, T.; Lamarca, A.; Gutierrez, C.; Durany, N.; Casals, N, (2011), "A Nucleotide-Based Drug Protects against Glutamate- and MPP+-Induced Neurotoxicity", Neuroscience and Medicine, vol. 2, pp. 154-160.
- Gao, S.; keung, W.; Serra, D.; Wang, W.; Carrasco, P.; Casals, N; Hegardt , FG.; Moran, TH.; Lopaschuk, GD., (2011), "Malonyl-CoA Mediates Leptin Hypothalamic Control of Feeding Independent of Inhibition of CPT-1a.", American journal of physiology. Regulatory integrative and comparative physiology, vol. 301, pp. 209-217, ISSN: 0363-6119.
- Al-Atari Abou-Asi, M; Barajas, M.; Hernandez Alfaro, F; Gil-Recio, C.; Fabregat, M.; Ferrés, E.; Giner Tarrida, L; Casals, N, (2011), "Isolation of pluripotent stem cells from human third molar dental pulp", Histology and histopathology, vol. 26, pp. 1057-1070, ISSN: 0213-3911.
- Gao, S.; Zhu, G.; Gao, X.; Wu, D.; Carrasco, P.; Casals, N; keung, W.; Hegardt , FG.; Moran, TH.; Lopaschuk, GD., (2011), "Important Roles for Brain-specific Carnitine Palmitoyltransferase and Ceramide Metabolism in Leptin Hypothalamic Control of Feeding", Proceedings of the National Academy of Sciences of the United States of America, vol. 108, pp. 9691-9696, ISSN: 0027-8424.
- Puisac, B.; Arnedo, M.; Casale, Cesar H.; Ribate, MP; Castiella, T.; Ramos, FJ; Ribes, A.; Pérez-Cerdá, C.; Casals, N; Hegardt , FG.; Pié, J., (2010), "Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria", Journal of inherited metabolic disease, vol. 33, No. 4, pp. 405-410, ISSN: 0141-8955.
- Ferre, E.; Martí, C.; Hernandez Alfaro, F; Klein-Nulend, J.; Casals, N, (2010), "Buccal fat pad, an oral access-source of human adipose stem cells with potential for osteochondral tissue engineering, an in vitro study", Tissue engineering. Part A, tissue engineering, vol. 16, No. 5, pp. 1083-1095, ISSN: 1937-3341.
- Pié, J.; Gil-Rodríguez, M.; Ciero, M.; López-Viñas, E.; Ribate, MP; Arnedo, M.; Deardorff, M.; Puisac, B.; Legarreta, J.; de Karam, JC; Egío, E.; Bueno, I.; Baldellou, A.; Calvo, MT; Casals, N; Olivares, JL; Losada, A.; Hegardt , FG., (2010), "Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome.", American Journal of Medical Genetics A, vol. 152A, pp. 924-929, ISSN: 1552-4833.
- Menao, S.; López-Viñas, E.; Flores-Mir, C.; Puisac, B.; Gratacós, E.; Arnedo, M.; Carrasco, P.; Serra, D.; Asins, G.; Ramos, FJ; Gómez-Puertas, P.; Hegardt , FG.; Casals, N; Pié, J., (2009), "Ten Novel HMGCL Mutations in 24 Patients of Different Origin with 3-Hydroxy-3-Methyl-Glutaric Aciduria", Human mutation, vol. 3, pp. 520-529, ISSN: 1059-7794.
- Sierra, A.; Gratacós, E.; Carrasco, P.; Clotet, J.; Ureña, J.; Serra, D.; Asins, G.; Hegardt, F.; Casals, N, (2008), "CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity", Journal of biological chemistry, vol. 283, No. 11, pp. 6878-6885, ISSN: 0021-9258.
- Casals, N, (2007), "A new lc-esi-ms/ms method to measure acylcarnitine levels in cultured cells", Analytica chimica acta, vol. 599, pp. 1-6, ISSN: 0003-2670.
- Casals, N, (2007), "Molecular genetics of HMG-CoA lyase deficiency", Molecular genetics and metabolism, vol. 92, pp. 198-209, ISSN: 1096-7192.
- Casals, N, (2007), "C-Terminal end amd aminoacid Lys48in HMG-CoA lyase are involved in substrate binding and enzyme activity.", Molecular genetics and metabolism, vol. 91, pp. 120-127, ISSN: 1096-7192.
- Casals, N, (2006), "Refining the diagnosis of mitochondrial HMG-CoA synthase deficiency", Journal of inherited metabolic disease, vol. 29, pp. 207-211, ISSN: 0141-8955.
- Casals, N, (2006), "A single residue mutation, G203E, causes 3-hydroxy-3-methylglutaric aciduria by occluding the substrate channel in the 3D structural model of HMG-CoA lyase", Journal of inherited metabolic disease, vol. 29, pp. 64-70, ISSN: 0141-8955.
- Casals, N, (2005), "Skipping of exon 2 and exon 2 plus 3 of HMG-CoA lyase (HL) gene produce the loss of beta sheet 1 and 2 at the recently proposed (beta-alfa)8 TIM barrel model of HL.", Biophysical chemistry, vol. 115, pp. 241-245, ISSN: 0301-4622.
- Casals, N; Gómez-Puertas, P.; Pié, J.; Mir, C.; Roca, R.; Puisac, B.; Aledo, R.; Clotet, J.; Menao, S.; Serra, D.; Asins, G.; Till, J.; Alun, C.; Jones, E.; Cresto, Juan C.; Chamoles, Nestor A; Abdenur, Jose E; Mayatepek, E.; Besley, G.; Valencia, A.; Hegardt , FG., (2003), "Structural (beta alpha)(8) TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase", Journal of biological chemistry, vol. 278, No. 31, pp. 29016-29023, ISSN: 0021-9258.
- Casals, N, (2003), "Molecular basis of 3-hydroxy 3-methylglutaric aciduria", Journal of physiology and biochemistry, vol. 59, pp. 311-322, ISSN: 1138-7548.
- Morillas, M.; Bentebibel, A.; Selles, E.; Casals, N; Valencia, A.; Hegardt , FG.; Asins, G.; Serra, D.; Gómez-Puertas, P., (2003), "Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition", Journal of biological chemistry, vol. 278, pp. 9058-9063, ISSN: 0021-9258.
- Muñoz, I.; Simón, E.; Casals, N; Clotet, J.; Ariño, J., (2003), "Identification of multicopy supressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae.", Yeast, vol. 30, pp. 157-169, ISSN: 0749-503X.
- Mir, C.; Clotet, J.; Aledo, R.; Durany, N.; Argemí Renom, J; Lozano, R.; Cervós-Navarro, J.; Casals, N, (2003), "CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons", Journal of molecular neuroscience, vol. 20, pp. 53-59, ISSN: 0895-8696.
- Casals, N, (2002), "Diagnosing mitochondrial HMG-CoA synthase deficiency", Journal of pediatrics, vol. 140, pp. 778-780, ISSN: 0022-3476.
- Casals, N, (2001), "The genetic basis of mitochondrial HMG-CoA synthase deficiency", Human genetics, vol. 109, pp. 19-23, ISSN: 0340-6717.
- Casals, N, (2001), "3-hydroxy-3-methylglutaryl CoA synthase-1 of Blattella germanica has structural and functional features of an active retrogene", Insect molecular biology, vol. 31, pp. 837-743, ISSN: 0962-1075.
- Casals, N, (1998), "A nonsense mutation in the exon 2 of the 3-hydroxy-3-methylglutaryl CoA lyase (HL) gene producing three mature mRNAs is the main cause of 3-hydroxy-3-methylglutaric aciduria in european mediterranean patients", Archives of biochemistry and biophysics, vol. 349, ISSN: 0003-9861.
- Casals, N, (1998), "Two missense point mutations in different alleles in the 3-hydroxy-3-methylglutaryl Coenzyme A Lyase gene produce 3-hydroxy-3methylglutaric aciduria in a french patient", Archives of biochemistry and biophysics, vol. 358, pp. 197-203, ISSN: 0003-9861.
- Casals, N, (1997), "A two-base deletion in exon 6 of the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene producing the skipping of exons 5 and 6 determines 3-hydroxy-3-methylglutaric aciduria", Journal of lipid research, vol. 38, pp. 90-100, ISSN: 0022-2275.
- Casals, N, (1997), "A nonsense mutation in the 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene produces exon-skipping in two patiens of different origin with hl deficiency", Biochemica journal, vol. 323, pp. 329-335, ISSN: 0264-6021.
- Casals, N, (1997), "Expression and activity of 3-hydroxy-3-methylglutaryl-CoA synthase and reductase in the fat body of ovariectomized and allatectomized Blattella germanica", Physiological entomology, vol. 22, pp. 6-12, ISSN: 0307-6962.
- Casals, N, (1996), "La prescripción farmacéutica en Catalunya tras el decreto de financiación selectiva de medicamentos", Gaceta sanitaria, vol. 10, pp. 183-190, ISSN: 0213-9111.
- Casals, N, (1996), "Coordinated Expression and Activity of 3-hydroxy-3-methylglutaryl CoA synthase and reductase in the fat body of Blattella germanica during vitellogenesis", Insect molecular biology, vol. 26, pp. 837-843, ISSN: 0962-1075.
- Casals, N, (1996), "An aberrant splicing by a point mutation and a deletion in 3-hydroxy-3-methylglutaryl coenzyme A lyase (HL) gene produce an hereditary hl deficiency", Journal of lipid research, vol. 37, pp. 2420-2431, ISSN: 0022-2275.
- Casals, N, (1994), "Blattella germanica Has Two HMG-CoA Synthase Genes. Both Are Regulated In The Ovarian Development", Journal of biological chemistry, vol. 269, pp. 11707-11713, ISSN: 0021-9258.
- Casals, N, (1993), "Regulation of Mitochondrial 3-Hydroxy-3-Methylglutaryl-coenzime A Synthase Protein by Starvation, Fat Feeding and Diabetes", Archives of biochemistry and biophysics, vol. 307, pp. 40-45, ISSN: 0003-9861.
- Casals, N, (1992), "Regulation of the expression of the mitochondrial 3-hidroxy-3-methylglutaryl-CoA synthase gene", Biochemica journal, vol. 283, ISSN: 0264-6021.
Projectes de recerca
-
EXPLORANDO LA RELEVANCIA DE LA INTERACCION DE CPT1C CON OTRAS PROTEINAS EN LA REGULACION DE LA HOMEOSTASIS ENERGETICA Y EL DESARROLLO DE LA OBESIDAD01/09/2021 - 31/08/2024IP: Casals, N; Rodriguez-Rodriguez, R.
Ministerio de Ciencia e Innovación (MICINN)
-
Administracion de fármacos específicos de la CPT1 central: una novedosa estrategia basada en nanomedicina para combatir obesidad y cáncer01/01/2019 - 31/12/2021IP: Rodriguez-Rodriguez, R.
MINISTERIO DE CIENCIA E INNOVACION
-
Cpt1c en el hipotálamo ventromedial como nueva diana terapéutica en la regulación del balance energético: mecanismos moleculares implicados01/01/2018 - 31/12/2020IP: Casals, N; Rodriguez-Rodriguez, R.
Ministerio de Economía, Industria y Competitividad
-
Carnitine palmitoyltransferase 1-mediated strategies to activate brown fat and reduce food intake to fight against obesity01/03/2017 - 01/03/2020IP: Casals, N; Serra, D.
Fundació la Marató de TV3
-
Regulation of Lipid Metabolism in Obesity and Diabetes (METALIP)01/01/2017 - 31/12/2019IP: Casals, N
Agencia de Gestió d'ajudas Universitaries Investigació AGAUR
-
Papel de la carnitina pamitoil transferasa 1C como sensor hipotalámico de aciles-CoA y regulador del metabolismo periférico de los lípidos (SAF2014-52223-C2-2-R)01/01/2015 - 31/12/2017IP: Casals, N
Ministerio de Ciencia e Innovación (MICINN)
-
Searching new biomarkers and therapeutic targets related to cognitive deficits in early stages of Alzheimer's Disease: Role of AKAP79/150, CPT1C and SSAO/VAP-1 in Abmediated AMPAR dysfunction.01/01/2015 - 31/12/2017IP: Casals, N; Rodríguez , J.
Fundació la Marató de TV3
-
Participación de CPT1C en la síntesis de ceramidas y el control de la ingesta alimentaria01/01/2012 - 31/12/2014IP: Casals, N
Ministerio de Economía y Competitividad
-
Homeostasi Energètica26/11/2009 - 31/12/2014IP: Casals, N
Generalitat de Catalunya
-
Bases moleculars de acción de las carnitina aciltransferasas como reguladoras de la oxidación de las grasas y su papel en la obesidad, la resistencia a la insulina y el apetito01/01/2008 - 31/12/2012IP: Hegardt , FG.
Ministerio de Ciencia y Tecnología
-
Càtedra cultura, ciència i religió01/09/2013 - 31/08/2016IP: Corcó, Josep
FUNDACIÓ BARCELONA I FAMÍLIA
-
Efecto del Nucleo CMP Forte en la regeneración neuronal del Sistema Nervioso Periférico01/05/2011 - 01/05/2012IP: Casals, N
Laboratorios Farmacéuticos Ferrer-Internacional
-
Neuroprotección del núcleo CMP forte en células nerviosas01/01/2006 - 31/12/2007IP: Casals, N
Laboratorios Farmacéuticos Ferrer-Internacional
-
Estudio del papel neuroprotector de la CDP-colina en la muerte neuronal inducida por el péptido beta-amiloide y el NO01/01/2002 - 31/12/2003IP: Casals, N
Laboratorios Farmacéuticos Ferrer-Internacional
-
Estudio del papel de la CDP-colina en la reducción de la apopotosis neuronal inducida por excitotoxicidad01/01/1999 - 31/12/2000IP: Casals, N
Laboratorios Farmacéuticos Ferrer-Internacional
Activitats
- NC-IUPHAR Symposium Ponència convidada "CPT1 proteins as targets in obesity treatment", 2023.
- Sefagia Presentació de poster "Regulation of autophagy by the CPT1C-SAC1 complex in neurons", 2022.
- EMBO Workshop Autophagy in brain health and disease Presentació de poster "Regulation of autophagy by the CPT1C-SAC1 complex in neurons", 2022.
- Women in Autophagy Annual Synposium Webinar Presentació de ponència curta (short paper) "Regulation of autophagy by the CPT1C-SAC1 complex in neurons", 2022.
- Reunión Anual de la Sociedad Española de Investigación sobre Cannabinoides Presentació de poster "CPT1C AS THE FIRST NEGATIVE REGULATOR OF THE ENDOCANNABINOIDS α/β-HYDROLASE CONTAINING 6 (ABHD6)", 2019.
- Copenhagen Bioscience Conference- Metabolism in action Presentació de poster "Deciphering the cross-talk relationship between brown fat thermogenesis and hypothalamic endocannabinoid dynamics during obesity development", 2019.
- Gordon Research Conference on Cannabinoid Function in the CNS Presentació de comunicació "CPT1C: a novel regulator of ABHD6 activity", 2019.
- Gordon Research Conference on Cannabinoid Function in the CNS Presentació de poster "The dynamic of endocannabinoids in the hypothalamus during obesity development in male and female mice and its cross-talk to Brown fat thermogenesis", 2019.
- European Atherosclerosis Society Congress Presentació de poster "POMACE OLIVE OIL ENRICHED IN OLEANOLIC ACID IMPROVES DIET-INDUCED OBESITY AND EXERTS PROTECTIVE EFFECTS IN VASCULAR DYSFUNCTION AND METABOLIC PARAMETERS", 2019.
- MetNet Annual Meeting: Targeting Metabolism to Develop New Therapies Presentació de comunicació "Carnitine palmitoyltransferase 1C as the first negative regulator of the endocannabinoids hydrolase ABHD6", 2019.